作者:卢巧英 赵巧萍 作者单位:浙江省东阳市中医院 东阳 322100 【摘要】 观察祛痰通络方治疗2型糖尿病的临床疗效。[方法]65例T2DM胰岛素抵抗患者随机分为治疗组 35例和对照组30例,治疗组服用祛痰通络方,对照组服用盐酸二甲双胍。两组疗程均为30d,治疗前后分别检测空腹血糖(FPG)、空腹胰岛素、血脂,计算胰岛素抵抗指数等。[结果]两组治疗前后比较各项检测指标均有显著改善(P<0.01),组间比较(P>0.05)。[结论]祛痰通络方对 T2DM 有确切的临床疗效,而且能明显改善患者的IR,降低胰岛素抵抗。 【关键词】 2型糖尿病 胰岛素抵抗 祛痰通络方 The Clinical Observation of Treating the Insulin Resistance of Type 2 Diabetes with Eliminating Phlegm and Unblocking the Collaterals Decoction Lu Qiaoying,Zhao Qiaoping Traditional Chinese Medicine Hospital of Dongyang City,Zhejiang Province(322100) Abstract:[Objective]To observe the clinical therapeutic effect of eliminating phlegm and unblocking the collaterals decoction on treating the insulin resistance of type 2 diabetes.[Method ]65 cases of insulin resistance of T2DM patients were divided randomly into two groups:35 in the therapeutic group taking the eliminating phlegm and unblocking the collaterals decoction and 30 in the control group taking dianoguanil.Both courses of treatment are 30 days,FPG,FINS,TC,TG,HDLC,LDLC,HOMAIR,etc.were tested before and after the treatment.[Result] All the indexes were significantly improved in both groups before and after the treatments(P<0.01),and the group comparison,P>0.05.[Conclusion ]Eliminating phlegm and unblocking the collaterals decoction does not only have pronounced therapeutic effect onT2DM,but also can improve IR as well as lower the insulin resistance. Key words: type 2 diabetes;insulin resistance;eliminating phlegm and unblocking the collaterals decoction 1 临床资料 2 方法 2.1 治疗方法 治疗组采用祛痰通络方,基本药物:瓜蒌、胆南星、法半夏、香附、川芎、黄芪。随症加减,气虚加党参、白术,重用山楂;血虚加何首乌、当归、桑寄生,重用丹参;热加大黄、黄芩、草决明;寒加干姜、肉桂、白芥子。常规水煎,每日1剂,分2次口服;对照组用二甲双胍片(丹东医创药业有限责任公司生产,批号:20070404)每次0.5g,每日3次。30d为1疗程。 2.2 观察方法 治疗前后分别测定空腹血糖(FPG)、空腹胰岛素(FINS)、血脂(TC、TG 、HDLC、LDLC)。血糖用葡萄糖氧化酶法测定,血脂用全自动生化分析仪测定,胰岛素用放免法测定,胰岛素抵抗指数(HOMAIR)采用Haffner[23]等在 Homa模型中计算 IR的公式 ,即:HOMAIR=FPG×FINs/22.5。 2.3 统计学方法 采用 SPSS13.0统计分析软件进行统计学处理。计量资料用x±s表示,采用 t检验,计数资料用x2检验。 3 治疗结果 3.1 对FPG、FINS、HOMAIR的影响,见表1。结果显示:治疗组与对照组治疗后FPG、FINS、HOMAIR均明显下降,P<0.01,两组间比较P>0.05, 说明两组药物均能改善糖代谢,且祛痰通络方也是通过改善IR而降低血糖的。 3.2 对血TC、TG 、HDLC、LDLC的影响,见表2。结果显示:治疗组治疗后血脂TC 、TG、LDLC明显降低,HDLC明显提高,前后比较P<0.01,疗效显著;对照组治疗后血脂无明显变化,P>0.05,表明祛痰通络方能明显改善脂代谢紊乱。 表1 两组治疗前后FPG、FINS、HOMAI的变化(略) 表2 两组治疗前后血TC、HDLC、LDLC的变化(略) 4 讨论 【参考文献】 |
|