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作者：Robles-Perez A 等 翻译：赵金霞 发布者：翟佳羽 审校者：李常虹
摘要： 早期诊断和治疗类风湿关节炎相关肺病可以延缓疾病进展。本研究的目的在于探讨早期类风湿关节炎患者无症状性肺部异常的发生率，以及血中反应性生物分子与肺受累的潜在关系。在一个无呼吸系统症状的早期类风湿关节炎队列中进行一项前瞻性观察性研究 (关节症状<><>
附原文： Early detection and treatment of lung disease in patients with rheumatoid arthritis (RA) may ameliorate disease progression. The objectives of this study were to investigate the frequency of asymptomatic lung abnormalities in early RA patients and the potential association of positive RA blood reactive biomolecules with lung involvement. A prospective observational study was performed in a cohort of patients with early RA (joint symptoms < 2="" years)="" without="" respiratory="" symptoms,="" who="" were="" included="" in="" a="" screening="" program="" for="" lung="" disease="" with="" a="" baseline="" chest="" radiograph="" (cr)="" and="" complete="" pulmonary="" function="" tests="" (pfts).="" in="" those="" patients="" with="" lung="" abnormalities="" on="" the="" cr="" or="" pfts,="" a="" high-resolution="" chest="" computed="" tomography="" scan="" (hrct)="" was="" performed.="" we="" included="" 40="" patients="" (30="" women).="" altered="" pfts="" were="" detected="" in="" 18="" (45%)="" of="" these="" patients.="" these="" cases="" had="" a="" diffusion="" lung="" transfer="" capacity="" of="" carbon="" monoxide="" (dlco)="" of=""><80% of="" predicted,="" without="" a="" significant="" reduction="" in="" the="" forced="" vital="" capacity.="" the="" hrct="" detected="" abnormalities="" in="" 11="" of="" the="" 18="" patients.="" diffuse="" bronchiectasis="" was="" the="" main="" finding.="" an="" inverse="" correlation="" between="" the="" anti-citrullinated="" peptide="" antibody="" (acpa)="" levels="" and="" dlco="" was="" found.="" asymptomatic="" lung="" disease="" is="" present="" in="" up="" to="" 45%="" of="" early="" ra="" patients="" and="" can="" be="" determined="" by="" pfts="" and="" acpa="">
引自： Robles-Perez A, Luburich P, Rodriguez-Sanchon B, et al.Preclinical lung disease in early rheumatoid arthritis. Chron Respir Dis. 2016 ;13(1):75-81.
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