Chapter three

Current Topics in Developmental Biology

Volume 99, 2012, Pages 59–78

MicroRNAs in Development

Chapter three – The Role of MicroRNAs in Muscle Development

• Nicholas S. Sokol

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doi:10.1016/B978-0-12-387038-4.00003-3

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Abstract

MicroRNAs play essential roles during animal development, including in developing muscle. Many microRNAs are expressed during muscle development and some, like miR-1 and miR-133, are muscle specific. Muscle microRNAs are integrated into myogenic regulatory networks: their expression is under the transcriptional and posttranscriptional control of myogenic factors, and they in turn have widespread control of muscle gene expression. This review summarizes recent work characterizing the function of microRNAs in muscle biology and specifically focuses on the genetic analysis of muscle microRNAs in a variety of model organisms including worms, flies, zebrafish, and mice.

Keywords

• MicroRNA;
• miRNA;
• Muscle;
• Development;
• Myogenesis;
• miR-1;
• miR-133;
• Mouse knockout

Copyright ? 2012 Elsevier Inc. All rights reserved.