0-(098
JOURNALOFDRUGSINDERMATOLOGY.(JULY2)VOL8ISSUE7SUPPL)S
GENOMICDRIVENINSIGHTSINTOCHANGESINAGINGSKIN
Authors:MichaelK.RobinsonPhD,RobertL.BinderPhD,ProfessorChristopherE.M.Griffiths
Likealltissues,theskinagesduetothepassageoftime(chronologicaging).However,skinisalsoexposedto
externalinsultssuchassunlight.Agingduetochronicsunexposure(photoaging)ischaracterizedclinicallyby
wrinkling,dyspigmentationandotherchanges.Chronologicandphotoagingofskinhavebeendistinguishedat
thestructural,cellularandmolecularlevels.However,manyunderlyingmechanismsremainamystery.Recent
sequencingofthehumangenomeanddevelopmentofgenome-widemicroarrayplatformsnowpermitanalysis
ofskinagingatthelevelofgeneexpression.Analysisofgeneexpressiondifferencesbetweenyoungandold
sun-protectedandsun-exposedskinshowedthatphotoagingproducesmanysimilar(butmoresevere)changes
ingeneexpressionversuschronologicaging.However,somechangesareuniquetooneformofagingorthe
other.Bioinformaticstoolsalsoenableanintegratedanalysisofgeneexpressionthemesandpathways,which
mayprovidenewinsightsintothemechanismsofskinagingandpossibleinterventions.
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