NuSkinAnti-Aging
Science
inreview
2014
Barcelona,
Spain
Berlin,
Germany
Bangkok,
Thailand
NewYork,
NY
“NuSkin,withitsanti-agingsciencethattargetthesourcesofaging,
standsapartfromthecompetitionbecauseourapproachisbackedbymore
than30yearsofanti-aginggeneexpressionresearch.Ourresearch
continuestogainrecognitionandisvalidatedthroughpresentationsatglobal
scientificconferences.”—JoeChang,Ph.D.
SantaBarbara,
CA
Anaheim,
CA
Helsinki,
Finland
LesDiablerets,
Switzerland
Tokyo,
Japan
Singapore
Taipei,
Taiwan
Hangzhou,
ChinaWuhan,China
HongKong,China
Sapporo,
Japan
Siena,
Italy
Corvallis,
OR
Paris,
FranceWashington
D.C.
Ventura,
CA
NewOrleans,
LA
Phoenix,
AZ
BuenosAires,
Argentina
Brussels,
Belgium
Atlanta,GA,
SanDiego,
CA
Raleigh,NC
Venice,Italy
Edinburgh,
Scotland
Boston,MA
Seoul,
South
Korea
Sydney,
Australia
Zurich,
Switzerland
Bologna,Italy
London,
England
Beijing,
China
Albuquerque,
NM
NewBrunswick,
NJ
Cannes,
France
NuSkinAnti-Aging
Science
Recent
Accomplishments
Presented
twoscientificpostersat
SocietyforInvestigative
Dermatology
Poster1
Poster2
Opened
theResearchCenteratthe
GreaterChinaInnovationPark
inFengxian,ChinainMay
2014,withitssixstate-of-the-
artlabs:
ResearchChemistryLab
MethodsDevelopmentLab
QualityChemistryLab
MicrobiologyLab
PilotPlantLab
ManufacturingQualityControlLab
NuSkinAnti-Aging
Science
PublicationsandPresentations
TotalPatents
LicensedPatents-PendingonFormulationor
Ingredients(5)
NuSkin-DevelopedPatents-PendingonFormulationor
Ingredients(11)
AcquiredPatentonMethod(1)
NuSkin-DevelopedPatent-PendingonMethod(4)
WeightManagementFormulationsandSystems(1)
MechanismforDispensingCustomizableSkinCare(4)
AwardsReceived
AngelaMastaloudis,Ph.D.Senior
Scientist,receivedtheDSM
NutraceuticalResearchAward,
ProceedingsoftheOxygenClubof
California2010WorldCongress
RemonaGopaul,AssociateSenior
Scientist,NamedYoungScientistof
theYearbytheSocietyofCosmetic
Chemists2010
NuSkinreceivedUtahInnovation
AwardforageLOCVitality:Natural
ProductsCategory,2011
Dr.JoeChangreceivedthe2012
GoldenBridgeAwards—Most
InnovativePersonoftheYear
NuSkinreceivedUtahInnovation
HonorableMentionAwardfor
ageLOCR2:ConsumerProducts
category,2012
PublishedScientificArticles
Kern,D.G.,Draelos,Z.D.,Meadows,C.,
Morré,D.J.,Morré,D.M.“ControllingReactive
OxygenSpeciesinSkinatTheirSourceto
ReduceSkinAging.”RejuvenationResearch.
2010Apr-Jun;13(2-3):165-7.
Gopaul,R.,Knaggs,H.,Langerveld,A.
“ReducingSkinStressResponsewithWillow
Bark-DerivedSalicin.”Cosmeticand
Toiletries,(July,2010):32-36.
Gopaul,R.,Gibson,M.,Knaggs,H.,Holley,
K.,Lephart,J.“AnEvaluationoftheEffectsof
aTopicalProductContainingSalicinonthe
VisibleSignsofHumanSkinAging.”Journal
ofCosmeticDermatology,9(3)2010:196-
201.
Knaggs,H.“InnovationinthePersonalCare
Industry.”JournalofCosmeticScience9(3)
2010;260-263
Bartlett,M.“Nutritionalandgeneticstrategies
forlongevity.”Anti-AgingMedicalNews.
Winter2010:36-40.
Gopaul,R.,Knaggs,H.,Wickett,R.“A
ReviewofGenomicTechniquesinCosmetic
Testing.”Cosmetics&Toiletries.February
2011,pp.112-117.
Tan,N.,Barger,J.,Zhang,Y.,Prolla,T.,Weindruch,R.,
Zhao,C.,Bartlett,M.,Zhu,J.“CordyMaxCs-4restores
aging-associatedchangesingeneexpressionandextends
lifespaninnormalagedmice.”Proceedingofthe10th
SymposiumofMycologySocietiesAcrossTaiwanStrait,
CentralChinaAgricultureUniversityPublishing.2011,pp
255-256.
Li,C.,Tan,N.,Barger,J.,Zhang,Y.,Ferguson,S.,Prolla,
T.,Zhu,J.“CombineduseofageLOCwhole-gene
expressionprofilingtechnologyandmouselifespantestin
anti-agingherbalproductstudy.”ProceedingofNewTCM
ProductsInnovationandIndustrialDevelopmentSummit,
ZhejiangUniversityPublishing,Hangzhou.27Nov.2011.
(inpress)
Chang,A.,Lingala,B.,Chang,T.,Kern,D.,Wood,S.,
Toyoda,H.,Knaggs,H.“AnExploratoryStudytoDetermine
theAssociationBetweenAssessedFacialSkinAgingand
PlasmaIsoprostaneLevelsinMiddle-AgedJapanese
Women.”Articlefirstpublishedonline:5Dec.2011
DermatologicalSurgery.
http://onlinelibrary.wiley.com/doi/10.1111/j.1524-
4725.2011.02235.x/abstract
Gopaul,R.,Kern,D.G.,Knaggs,H.E.,Lephart,J.F.(2012)
NarcissustazettaandSchizandrachinensistoRegulate
?YouthGeneClusters?—AnInvitroAnalysis.Cosmetics&
Toiletries;127,6:446-450.
Gopaul,R.,Knaggs,H.E.,Lephart,E.D.(2012),
Biochemicalinvestigationandgeneanalysisofequol:A
plantandsoy-derivedisoflavonoidwithanti-agingand
antioxidantpropertieswithpotentialhumanskin
applications.BioFactors.doi:10.1002/biof.191
Mastaloudis,A.,Wood,S.M.Age-RelatedChanges
inCellularProtection,PurificationandInflammation-
RelatedGeneExpression:RoleofDietary
Phytochemicals.AnnalsoftheNewYorkAcademy
ofSciences.1259(1):112-120;2012.
Mastaloudis,A.AUniqueNutritionalFormulationto
PromoteCellularProtectionandPurificationVia
InductionoftheNrf2-mediatedARE/PhaseII
DetoxificationPathways.SecondInternational
ConferenceonEnvironmentalStressorsinBiology
andMedicine.Medimonds.l.r.Bologna,Italy.11-17;
2012.
Holley,K.C.,Knaggs,H.E.WhyDon?tILook
Younger?EuroCosmetics2013,21:p.32.
Barger,J.L.,Vann,J.M.,Mastaloudis,A.,Wood,
S.M.,Bartlett,M.R.,Prolla,T.A.,Weindruch,R.
Identificationoftranscriptionaltargetsofhealthspan
inadiposetissueandmodulationbyresveratrol.
NutritionandAging2014;2:157-63.
MeadowsC,MorreDJ,MorreDM,DraelosZD,and
KernD.Age-RelatedNADHOxidase(arNOX)-
CatalyzedOxidativeDamagetoSkinProteins.
ArchivesofDermatologicalResearch,June2014.
http://www.ncbi.nlm.nih.gov/pubmed/24906676.
OralPresentations
“Resveratrolmimicscaloricrestrictionandretards
agingintheheart.”Oxidantsandantioxidantsin
biology,OxygenClubofCaliforniaWorldCongress,
SantaBarbara,CA,March17-20,2010.Prolla,T.
“AgingandGenes—theLinkwithSkin.”NewYork
SocietyofCosmeticChemistsMeeting,March
2010,Knaggs,H.
“Transcriptionalbiomarkersofageandtheir
modulationbydietaryintervention.”InvitedSpeaker:
CoLONGY,The1stInternationalCongresson
ControversiesinLongevity,HealthandAging.
Barcelona,Spain,June24-27,2010.Barger,J.,
Wood,S.M.,Weindruch,R.,Prolla,T.
“MitochondriaandAging.”JapanSymposium.
MechanismsofAgeingandDevelopment,
September2010;13:449-450;480-486.Prolla,T.
“Anutritionalstrategytoopposethegenetic
expressionofagingandlossofvitality.”1stWorld
CongressonTargetingMitochondria,Strategies,
InnovationandClinicalApplications,Berlin,
Germany,November18-19,2010.Wood,S.M.,
Ferguson,S.B.,Barger,J.L.,Prolla,T.A.,
Weindruch,R.,Bartlett,M.
“Targetingage-relatedgeneexpressionimproves
mentalandphysicalvitality.”1stWorldCongresson
TargetingMitochondria,Strategies,Innovationand
ClinicalApplications,Berlin,Germany,November
18-19,2010.Ferguson,S.B.,Tan,N.,Dong,Y.,Lu,
J.,Fisk,N.A.,Wood,S.M.,Zhu,J.,Bartlett,M.
“GenesandAging:LinkstoSkin,”In-CosmeticsAsia;
Bangkok,Thailand,November2010.Knaggs,H.
“WhyDoPeopleLookYoungerforTheirAge,”Asian
CosmeticChemistrySociety,Singapore,China,
November2010.Knaggs,H.
“Areviewofcurrentgenomictechniquesusedin
geneexpressionprofilingoftheskin,”Societyof
CosmeticChemistsAnnualMeeting;NewYork,New
York,December2010.Gopaul,R.
“Transcriptionalbiomarkersofcalorierestrictionand
theirmodulationbydietaryinterventions.”Invited
Speaker:FreeRadicals,NutritionandAging:From
FundamentalAspectstoClinicalApplications.Paris,
France,June15-17,2011.Barger,J.
“CordyMaxCs-4restoresaging-associatedchanges
ingeneexpressionandextendslifespaninnormal
agedmice.”The10thSymposiumofMycology
SocietiesAcrossTaiwanStrait,Wuhan,China,July
17,2011.Tan,N.,Barger,J.,Ferguson,S.,Zhang,
Y.,Prolla,T.,Zhu,J.
“Transcriptionalbiomarkersofcalorierestrictionin
adiposetissueandmodulationbydietary
interventions.”InvitedSpeaker:LinusPauling
InstituteDietandOptimumHealthConference.
Corvallis,OR,September13-16,2011.Barger,J.
“Auniquenutritionalformulationtopromotecellular
protectionandpurificationviainductionoftheNrf2-
mediatedARE/PhaseIIdetoxificationpathways.”
InvitedSpeaker:SecondInternationalConference
onEnvironmentalStressorsinBiologyand
Medicine.CentroDidattico,PoliclinicoLeScotte
Siena,Italy.October5-7,2011.Mastaloudis,A.
“RestructuringoftheECMinhumanskinbyequol:
aplantandsoy-derivedisoflavonoid.”Gene
ExpressionandProteinEvidencepresentedatthe
4thInternationalConferenceandExhibitionfor
NutraceuticalsandFunctionalFoods,Sapporo,
Japan,November2011.Gopaul,R.,Knaggs,H.,
Lephart,E.
“Whole-genetranscriptionalprofilingtodetect
aging-associatedmitochondriadysfunctionandto
developananti-agingproduct.”InvitedSpeaker:
The2011InternationalConferenceonFood
Factors,Taiwan,November20-23,2011.Zhu,J.,
Dong,Y.,Barger,J.,Lu,J.,Tan,N.,Prolla,T.,
Weindruch,R.,Bartlett,M.
“CombinationofageLOCbiochipwhole-gene
expressionprofilingandmouselifespantestinCM
anti-agingstudy.”InvitedSpeaker:SummitofNew
TCMproductDevelopmentandIndustrial
DevelopmentStrategy,Hangzhou,China,
November25-27,2011.Li,C.,Tan,N.,Barger,J.,
Ferguson,S.,Zhang,Y.,Prolla,T.,Zhu,J.
OralPresentations
“WhyDon?tILookYounger?”PresentedatHBA
GlobalExpoinNewYorkCity,NY;June2012.
Knaggs,H.E.
“Experimentalproofoflifespanextensionproperty
andthemolecularmechanismsofanti-agingherbs
CordycepssinensisandGanodermalucidum.”
InvitedSpeaker:TWGHsSophiaWangEddieWang
IntegratedChineseandWesternMedicine
Symposium2012/13,HongKong,China,March7,
2013.Zhu,Josh.
“Amplicondensity-weightedalgorithmsanalyzehigh
dissimilarityanddynamicalterationsofRAPD
molecularmarkerpolymorphismsintheintegrated
microecologyCordycepssinensiswithmultiple
fungi.”The11thSymposiumofMycolSocieties
crossTaiwanStrait,Beijing,China,May17-19
2013.Zhu,Josh.
“Transcriptionalbiomarkersofagingandmodulation
bydietaryinterventions”InternationalAssociationof
GerontologyandGeriatrics:Seoul,SouthKorea,
June25,2013.Barger,J.
"Conservedpathwaystolongevityandmodulation
byresveratrol”WineHealth2013:Sydney,
Australia,July19,2013.Barger,J.
“Anti-oxidationandlifespanextensionactivitiesof
CordycepssinensisCs-4.”The7thInternational
MedicinalMushroomConference,Beijing,China,
August26-29,2013.Zhu,J.,Wu,Z.
“Anti-oxidationandlifespanextensionactivitiesof
CordycepssinensisCs-4andtheanti-aging
molecularmechanisms.”BiennialMeetingof
SocietyforFreeRadicalResearch-Asia,Taiwan,
October16-19,2013.Zhu,J.,Tan,L.
“Resveratrolmimicshealthspaneffectsofcalorie
restrictioninwhiteadiposetissue"?6thInternational
ConferenceonPolyphenolsandHealth:Buenos
Aires,Argentina,October19,2013.Barger,J.
"Nutrigenomicapproachestoslowingtheaging
process”Vision2020Seminarseries,Universityof
Zurich,November21,2013.Barger,J.
“TheBigDebate:WhereIndustryProfessionalsSee
theFutureoftheIndustryGoing.”CosmeticsVision
March5-7,2014inCannes,France,King,Will,
Pessikoff,Robert,andKnaggs,Helen.
“BrandCaseStudy:ExploringtheChallengesand
OpportunitiesinDoingBusinessinGlobalMarkets.”
HBAJune12,2014inNewYork,NY.Knaggs,
Helen.
“IdentificationofNovelMechanismsbehindSkin
Aging.”Happi?sAnti-AgingConference,September
16,2014inNewBrunswick,NJ.Knaggs,Helen.
“ExploringtheChallengesandOpportunitiesin
DoingBusinessinGlobalMarkets.”Happi?sAnti-
AgingConference,September17,2014inNew
Brunswick,NJ.Knaggs,Helen.
ScientificPosters
“Newskinbenefitsforwhitewillowbarkextract.”
TheSocietyofCosmeticChemistsTechnology
Showcase,December2009.Gopaul,R.,
Langerveld,A.,Lephart,J.,Knaggs,H.
“Antioxidationandlifespan-extensionactivitiesof
CordyMaxinoxidativestressandagingmodels
#A177.”OxidantsandAntioxidantsinBiology,
OxygenClubofCaliforniaWorldCongress,March
17-20,2010,SantaBarbara,CA.Zhu,J.,Zhang,Y.,
Yang,J.,Tan,N.,Zhao,C.,andMastaloudis,A.
(receivedDSMResearchAward)
“Age-Relatedoxidase(arNOX)implicatedinaging-
relatedoxidativedamagetoskinproteins,”Oxygen
ClubofCaliforniaWorldCongress,March2010,
SantaBarbara,California.Morré,D.M.,Morré,D.J.,
Meadows,C.,Draelos,Z.,andKern,D.G.
“CordyMaxextendsthelifespaninanagingmodel:
apreliminaryreport,Abstract#A310.”Experimental
Biology?10,April24-28,2010Anaheim,CA.Tan,
N.,Zhang,Y.,Yang,J.,Zhao,C.,andZhu,J.S.
“Improvementofexercisemetabolismand
carotenoidantioxidantscoreswithCordyMaxand
LifePakinyoungChineseeliteathletes,Abstract
#D356.”ExperimentalBiology?10,April24-28,2010
Anaheim,CA.Duan,L.,Zhao,L.,Liang,C.,Lu,L.,
Gao,L.,Li,G.,Zhu,J.S.
“Maturationalalterationofdifferentialexpressionsof
GC:AT-biasedgenotypesofCordycepssinensisfungi
andPaecilomyceshepialiinCordycepssinensis,
Abstract#B210.”ExperimentalBiology?10,April24-
28,2010Anaheim,CA.Zhu,J.S.,Gao,L.,Yao,Y.,
Zhou,Y.
“AntioxidationactivitiesofCordyMaxinanoxidative
stressmodel:amechanismofitsanti-aging
properties,Abstract#311.”ExperimentalBiology?10,
April24-28,2010Anaheim,CA.Yang,J.,Tan,N.,
Zhao,C.,Zhang,Y.,andZhu,J.S.
“AppearanceinJapanesewomencorrelateswith
age-relatedNADHoxidaselevelsandbloodmarkers
oflipidoxidation,”SocietyforInvestigative
Dermatology;J.InvestDermatol130.S.6(May
2010).Morré,D.J.,Morré,D.M.,Kern,D.G.,Wood,
S.M.
“Regulatingtheexpressionofgenesassociatedwith
thesynthesisandmaintenanceofdermalhyaluronan
andbarrierlipidsviatopicaltreatmentofsalicin—an
Invitroanalysis,”SocietyforInvestigative
Dermatology;J.InvestDermatol130.S.84,May
2010.Gopaul,R.,Knaggs,H.
“Salicinregulatestheexpressionof?functionalyouth
geneclusters?toreflectamoreyouthfulskinprofile,”
InternationalFederationofSocietiesofCosmetic
ChemistsAnnualMeeting,May2010,BuenosAires,
Argentina.Gopaul,R.,Langerveld,A.,Knaggs,H.,
Lephart,J.
“InhibitionbycoenzymeQ10ofage-relatedoxidase
(arNOX)causedoxidativedamageinskinproteins,”
InternationalCoenzymeQAssociationMeeting,
May2010,Brussels,Belgium.Morré,D.M.,Morré,
D.J.,Meadows,C.,Draelos,Z.,Kern,D.G.
“AppearanceinJapanesewomencorrelateswith
thepresenceofinosotidesandlysolipids,both
significantinhibitorsofage-relatedNADHoxidase
levels,”40thAnnualEuropeanSocietyfor
DermatologicalResearch,June2010.Morré,D.J.,
Morré,D.M.,Kern,D.G.,Wood,S.M.,Toyoda,H.,
Knaggs,H.
“Transcriptionalbiomarkersofmitochondrialaging
andmodulationbyCordycepsSinensisCs-4.”
GordonResearchConference,BiologyofAging,
DeterminantsofHealth-Span:FromCellsto
Humans,LesDiblerets,Switzerland,August21-27,
2010.Wood,S.M.,Barger,J.,Prolla,T.A.,
Weindruch,R.,Mastaloudis,A.,Ferguson,S.
“Anti-Agingeffectsofsuperoxidereductioninskin
bytheapplicationofspecificinhibitorsofage-
relatedNADHoxidase(arNOX),”International
FederationofSocietiesofCosmeticChemists,
September2010,BuenosAires,Argentina.Kern,
D.G.,Meadows,C.,Fuller,B.B.,Knaggs,H.,Morr?,
D.M.,Morr?,D.J.
“Salicinreducestheexpressionofgenesassociated
withskininflammation—aninvitroanalysis,”
SocietyforInvestigativeDermatology;J.Invest
Dermatol130.S.85,September2010.Gopaul,R.,
Knaggs,H.
“Exploratorystudytoassessassociationofskin
agingwithplasmaisoprostanelevelsinhealthy
middle-agedJapanesewomen.”TheAmerican
AcademyofDermatology?s69thAnnualMeeting,
February2011,NewOrleans,LA.Chang,A.,
Chang,T.,Lingala,B.,Kern,D.,Wood,S.,Toyoda,
H.,Knaggs,H.
“APCR-basedscreentoidentifynaturalcompounds
withtheabilitytoinfluenceNrf2-mediated
transcriptionalinductionofdetoxification/antioxidant
genes.”GordonResearchConference:Oxidative
Stress&Disease.EmergingResearchAreasinthe
StudyofOxidativeStressandDisease.March13-
18,2011,Ventura,CA.Mastaloudis,A.,Barger,J.,
Prolla,T.,Weindruch,R.,Ferguson,S.,Wood,S.
“CordycepssinensisCs-4restoresaging-
associatedchangesingeneexpressionand
extendslifespaninnormalagedmice.”Progressin
Nutrition2011.The5thInternationalSymposium,
“PromotingGoodHealthandDevelopinga
SustainableEnvironment,”HongKong,March10-
11,2011.Zhu,J.,Tan,N.,Barger,J.,Zhang,Y.,
Prolla,T.,Weindruch,R.,Zhao,C.,Bartlett,M.
“ageLOCVitalityimprovesexerciseendurance,
glucosemetabolismandantioxidantcapacityinan
agingmodel.”ProgressinNutrition2011.The5th
InternationalSymposium,“PromotingGoodHealth
andDevelopingaSustainableEnvironment,”Hong
Kong,March10-11,2011.Zhu,J.,Yang,J.,Dong,
Y.,Zhao,C.,Wu,Z.,Zhang,Y.,Tan,N.,Lu,J.,
Bartlett,M.
“Thelifespan-prolongingeffectofCordycepssinensis
Cs-4innormalmiceanditsmolecularmechanisms.”
FASEBJ201125(1):599.1.ExperimentalBiology
2011,Washington,DC,Apr.10,2011.Tan,N.,
Barger,J.,Zhang,Y.,Prolla,T.,Weindruch,R.,
Zhao,C.,Bartlett,M.,Zhu,J.
“ageLOCVitalityimprovesenduranceexercise,
exerciseglucosemetabolismandantioxidant
capacityinanagingmodel.”FASEBJ201125(1):
1049.2.ExperimentalBiology2011,Washington,DC,
Apr.12,2011.Yang,J.,Dong,Y.,Zhao,C.,Wu,Z.,
Zhang,Y.,Tan,N.,Lu,J.,Bartlett,M.,Zhu,J.
“CordycepssinensisCs-4restoresaging-associated
changesingeneexpressionandextendslifespanin
normalagedmice.”FASEBJ201125(1):1090.13.
Experimental2011,Washington,DC,Apr.13,2011.
Tan,N.,Barger,J.,Zhang,Y.,Prolla,T.,Weindruch,
R.,Zhao,C.,Bartlett,M.,Zhu,J.
“AnageLOCVitalityformulaimprovesendurance
exerciseinagedmiceandenergymetabolismin
musclemitochondria.”FASEBJ201125(1):1114.9.
ExperimentalBiology2011,Washington,DC,Apr.
13,2011.Dong,Y.,Lu,J.,Yang,J.,Zhao,C.,Tan,
N.,Wu,Z.,Zhang,Y.,Gao,L.,Bartlett,M.,Zhu,J.
“Associationofskinagingseveritywithblood
isoprostanelevelsinhealthymiddle-agedJapanese
women.”SocietyforInvestigativeDermatology
(SID)May2011,J.InvestDermatol131.S.85
(2011).Chang,T.,Lingala,B.,Kern,D.,Wood,S.,
Toyoda,H.,Knaggs,H.,Chang,A.
“CordyMaxCs-4restoresaging-associatedchanges
ingeneexpressionandextendslifespaninnormal
agedmice.”Proceedingofthe10thSymposiumof
MycologySocietiescrossTaiwanStrait,Central
ChinaAgricultureUniversity.2011,pp255-256.
Oralpresentationat:The10thSymposiumof
MycologySocietiesCrossTaiwanStrait,Wuhan,
China,July17,2011.Tan,N.,Barger,J.,Ferguson,
S.,Zhang,Y.,Prolla,T.,Zhu,J.
“Amultifactorialapproachtoaddressingbody
appearanceaging.”EuropeanSocietyfor
DermatologicalResearch(ESDR)September2011,
J.InvestDermatol131.S.54(2011).Knaggs,H.,
Kern,D.,Gopaul,R.,Langerveld,A.
“Amultifactorialgeneexpressionapproachto
understandingskinaging.”J.InvestDermatol131.
S.57,September2011.Knaggs,H.,Kern,D.,
Bartlett,M.,Wood,S.,Mastaloudis,A.,Ferguson,
S.,Langerveld,A.
ScientificPosters
“Asystematicapproachtoevaluateandrank
naturalingredientsbasedontheirabilitytooppose
age-relatedchangesingeneexpression.”Linus
PaulingInstituteDietandOptimumHealth
Conference.Corvallis,OR.September13-16,2011.
Wood,S.,Mastaloudis,A.,Barger,J.,Prolla,T.,
Weindruch,R.
“Auniqueblendofnaturalcompoundswiththe
abilitytoopposeage-relatedchangesingene
expressionrelatedtodysregulationofremovalof
cellulardebris,cellulardetoxification,antioxidant
protectionandinflammatorybalance.”Second
InternationalConferenceonEnvironmental
StressorsinBiologyandMedicine.October5-7,
2011,CentroDidattico,PoliclinicoLeScotteSiena,
Italy.Mastaloudis,A.,Barger,J.,Prolla,T.,
Weindruch,R.,Bartlett,M.,Wood,S.
“Whole-genetranscriptionalprofilingtodetect
aging-associatedmitochondriadysfunctionandto
developananti-agingproduct.”Proceedingof2011
InternationalConferenceonFoodFactors.Zhu,
J.S.,Dong,Y.Z.,Barger,J.L.,Lu,J.H.,Tan,N.Z.,
Prolla,T.A.,Weindruch,R.,Bartlett,M.Invited
Speakerat:The2011InternationalConferenceon
FoodFactors,Taiwan,November20-23,2011.
“CombinationofageLOCbiochipwhole-gene
expressionprofilingandmouselifespantestinCM
anti-agingstudy.”ProceedingofSummitofNewTCM
productDevelopmentandIndustrialDevelopment
Strategy,ChinaJChineseMaterialMedical
Publishing.2011.Li,C.L.,Tan,N.,Barger,J.,
Ferguson,S.,Zhang,Y.,Prolla,T.,Zhu,J.Invited
Speakerat:SummitofNewTCMproduct
DevelopmentandIndustrialDevelopmentStrategy,
Hangzhou,China,November25-27,2011.
“Influencingtheexpressionofgenesassociatedwith
skininflammationbycombiningnarcissustazetta
bulbextractandschizandrachinensisfruitextract—
aninvitroanalysis.”SocietyofCosmeticChemists
AnnualScientificSeminar,NewYork,NY,December
2011.Gopaul,R.,Knaggs,H.,Kern,D.
“SoWhyDon?tILookYounger?”International
FederationofSocietiesofCosmeticChemists,
Bangkok,Thailand,December14-15,2011.Kern,D.,
Chang,A.,Wood,S.,Gopaul,R.,Lephart,J.,
Knaggs,H.
“Transcriptionalprofilingtoidentifygenescontrolling
humanskinaging”presentedatthe70thAnnual
MeetingoftheAmericanAcademyofDermatologyin
SanDiegoonMarch16-20,2012.JAmAcad
Dermatol66(4),AB32(2012).Chang,A.L.S.,Spitale,
R.,Torre,E.,Lingala,B.,Chang,H.Y.,Kern,D.G.,
Wood,S.M.,Knaggs,H.E.
“L.Digitatainfluencesexpressionofgenesrelated
tovasculatureandmaythereforebebeneficialfor
improvingtheappearanceofcellulite”presentedat
SocietyforInvestigativeDermatology,May9-12,
2012.SupplementtotheJournalofInvestigative
Dermatology132(1),S65(2012).Gopaul,R.,Kern,
D.G.,Knaggs,H.E.
“L.Digitatainfluencesgeneexpressionrelatingto
adipogenesisandlipolysisandthusmaybeusedas
anactiveingredientforaddressingcellulite”
presentedatSocietyforInvestigativeDermatology,
May9-12,2012.SupplementtotheJournalof
InvestigativeDermatology132(1),S65(2012).
Gopaul,R.,Kern,D.G.,Knaggs,H.E.
“Auniqueblendofnaturalcompoundsopposes
age-relatedchangesingeneexpressionrelatedto
dysregulationofcellulardetoxificationand
antioxidantprotection.”SocietyforFreeRadical
ResearchInternational,London,England.
September6-9,2012.Mastaloudis,A.,Barger,J.L.,
Prolla,T.A.,Weindruch,R.,Wood,S.M.
“Microcurrentskintreatmentoutperformsastandard
retinoltopicalinthetreatmentofcelluliteskin
topography”presentedatthe42ndAnnualMeeting
oftheEuropeanSocietyforDermatological
ResearchinVenice,ItalyonSeptember19-22,
2012.Kern,D.G.,Draelos,Z.D.,Gopaul,R.,
Lephart,J.,Knaggs,H.E.
ScientificPosters
“Regulatingtheexpressionofgenesassociated
withtheprotectionandmaintenanceofskin
structureviatopicaltreatmentofnarcisscustazetta
bulbextractandschizandrachinensisfruitextract-
aninvitroanalysis”presentedatthe42ndAnnual
MeetingoftheEuropeanSocietyforDermatological
ResearchinVenice,ItalyonSeptember19-22,
2012.Gopaul,R.,Kern,D.G.,Knaggs,H.E.,
Lephart,J.F.
“Targetinggenesrelatedtoskinfirmness—anin-
vitroapproach”presentedattheAnnualSocietyof
CosmeticChemistsMeetinginNewYork,NYon
December6-7,2012.Gopaul,R.,Knaggs,H.E.,
Kern,D.G.,Lephart,J.F.
“Weightmanagementprogram,includingablendof
naturalcompounds,facilitatesweightlossin
overweightmenandwomen:apilotstudy.”
ExperimentalBiology,BostonMA.FASEBJApril9,
201327:851.14.Wood,S.M.,Poole,S.,Burke,D.,
Bartlett,M.,Mastaloudis,A.
“Effectsofanoveldietarysupplementonphysical
andmentalfunctioninmiddle-agedadults:a
double-blind,randomized,placebo-controlledtrial.”
ExperimentalBiology,Boston,MA.FASEBJApril
9,201327:1076.8.Wood,S.M.,Poole,S.,Bartlett,
M.,Mastaloudis,A.,Burke,D.
“ageLOCVitalityimprovesmemoryandlearning
abilityinmemoryimpairmentmodels.”Experimental
Biology,BostonMA.FASEBJApril9,201327:
661.4.N-Z.Tan,J-Y.Yang,G.Yang,J-S.Zhu.
“ChangesinRAPDmolecularmarkerpolymorphism
duringCordycepssinensismaturation.”Experimental
Biology,BostonMA.FASEBJApril9,201327:
1079.13.L.Gao,Y-S.Yao,Z.Wu,J-S.Zhu.
“Cs-5modulatingimmuneresponseinanormaladult
model.”ExperimentalBiology,BostonMA.FASEBJ
April9,201327:866.1.L.Gao,Y.Zhang,J-H.Lu,N-
Z.Tan,J-SZhu.
“CordycepssinensisCs-5enhancessexualfunctions
innormalandimpotentmodels.”ExperimentalBiology,
BostonMA.FASEBJApril9,201327:1167.8.J-Y.
Yang,Y.Zhang,Y-Z.dong,N-Z.Tan,J-H.Lu,J-S.
Zhu.
“Aninstrument-appliedtopicalproductaffectsskin
microvasculatureandmaythereforebebeneficialfor
improvingtheappearanceofcellulite”presentedatthe
InternationalInvestigativeDermatologymeetingon
May8-11,2013inEdinburgh,Scotland.Kern,D.G.,
Stephens,T.J.,Knaggs,H.E.
“Aninvitromethodforidentifyingagentswithlipofilling-
likeactivity:ParallelAssessmentoflipidaccumulation,
toxicityandgeneexpression”presentedatthe
InternationalInvestigativeDermatologymeetingon
May8-11,2013inEdinburgh,Scotland.Kern,D.G.,
Knaggs,H.E.,Gopaul,R.,Bevis,D.J.,Kilkuskie,R.E.,
Lehigh,E.A.,Langerveld,A.J.,Pfund,W.P.
“Targetinggenesrelatedtoskinfirmness—aninvitro
approach”presentedatSocietyofCosmeticsChemist
inDecember12-13,2013inNewYork,NewYork.
Gopaul,R.,Kern,D.G.,Namkoong,J.,Knaggs,H.
ScientificPosters
“IdentificationofGeneExpressionSignaturesinOlder
WomenwithYouthfulAppearingSkin,”presentedat
SocietyforInvestigativeDermatology(SID)in
Albuquerque,NMonMay7-10,2014.Chang,A.S.,
Spitale,R.,Li,R.,Torre,E.,Kern,D.G.,Knaggs,H.E.
“AninvitroMethodforIdentifyingAgentswith
Lipofilling-likeActivity:AssessmentofLipid
Accumulation,TissueSource,Age,andGene
Expression”presentedatSocietyforInvestigative
Dermatology(SID)inAlbuquerque,NMonMay7-10,
2014.Kern,D.G.,Namkoong,J.,Knaggs,H.E.,
Gopaul,R.,Bevis,D.J.,Kilkuskie,R.E.,Lehigh,E.A.,
Langerveld,A.J.,Pfund,W.P.
“ASpecialLunchPresentation:NuSkinCompany
HighlightingRecentScientificPosters”presentedat
Happi?sAnti-AgingConference,September17,2014,
Namkoong,Jin.
summary
WebelieveNuSkin?songoingresearch,theopeningofNuSkin?s
CenterforAnti-AgingResearchandtheResearchCenterinGreater
China,andtheacquisitionofLifeGenTechnologies—withitsmore
than30yearsofexperiencestudyinganti-aging—willdeepenthe
company?sunderstandingofgeneexpressionanditsimpactonthe
effectsofagingevenlaterinlife.
“Giventhepositiveresponsethatwehaveseenfromthescientific
communityonourresearchefforts,wearelookingforwardto
continuingourresearchontheagingprocess.”—JosephChang,Ph.D.,
NuSkinChiefScientificOfficerandExecutiveVPofProductDevelopment
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