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来自日本东北大学的研究人员近日通过研究发现，对于顽固性高血压(treatment-resistant hypertension)的2型糖尿病患者而言，对患者前臂进行20分钟的超声波治疗或可明显降低患者的血压，相关研究刊登于International Journal of Cardiology杂志上。 据估计全世界有大约750万人死于高血压，而且目前研究者很难控制某些2型糖尿病高血压患者的病情。 这项研究中，研究者Katsunori Nonogaki及其同事对招募的212名顽固性高血压且患2型糖尿病的患者进行深入研究；研究者将研究对象分为四组，其中一组进行20分钟低频率（800赫兹）、低强度的前臂超声波辐射治疗；第二组进行20分钟的500赫兹的低强度辐射治疗；另外两组作为对照进行研究。 研究者发现，相比治疗前而言，接受800赫兹和500赫兹超声波辐射治疗患者机体的血压和脉搏明显下降了，而且相比对照组而言，治疗组患者的血压水平也明显降低了，但500赫兹治疗组患者的血压水平降低较为明显，同时进行超声波疗法对患者机体并无任何副作用影响。 研究者表示，超声波辐射治疗改善患者机体血压的分子机制目前尚不清楚，但我们推测，超声波辐射治疗或许可以抑制患者机体交感神经的活性，从而依靠前臂到机体心血管系统的神经通路来帮助患者降低血压。最后研究者Nonogaki说道，目前我们并没有有效的疗法来治疗顽固性高血压，而且抗高血压药物对于患者而言又非常昂贵，因此利用超声波辐射治疗或许是一种廉价且非侵入性的安全降压疗法，当然后期我们还会进行大量深入研究来证实这种超声波疗法的效果。 原文阅读
1.Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Noriko Satoh, Miki Hazama, Kouji Takeda, Nobuyuki Tsujita, Shuichi Katoh, Nariki Kubota. r Background Despite lifestyle interventions and various types of anti-hypertension agents, hypertension remains difficult to control in some patients with type 2 diabetes. As a noninvasive device-based approach for the treatment of clinic hypertension, we examined the effects of low-frequency and low-intensity ultrasound (500 or 800?kHz, 25?mW/cm2) applied to the forearm on blood pressure (BP) and pulse rate in Japanese subjects with type 2 diabetes and hypertension. Methods We examined the effects of low-frequency and low-intensity ultrasound (500 or 800?kHz, 25?mW/cm2) applied to the forearm on BP, pulse rate, and pulse pressure in 212 Japanese subjects (82 men and 130 women; mean age?±?SE, 65?±?1?years) with type 2 diabetes and hypertension (systolic BP?>?140?mmHg). The subjects were treated with anti-hypertension agents. Results Systolic and diastolic BP, pulse rate, pulse pressure in the 800-kHz ultrasound treatment group were significantly lower than the baseline values in hypertensive subjects with type 2 diabetes, and lower than those of placebo controls. In addition, systolic and diastolic BP, pulse rate, and pulse pressure in the 500-kHz ultrasound treatment group were significantly lower than the baseline values in hypertensive subjects with type 2 diabetes, and systolic BP, pulse rate, and pulse pressure were significantly lower than those of placebo controls. Conclusions Low-frequency (800?kHz or 500?kHz) and low-intensity (25?mW/cm2) ultrasound irradiation to the forearm might have potential usefulness as a therapeutic application for clinic hypertension in subjects with type 2 diabetes. http://www./article/S0167-5273(16)30767-7/abstract |
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