杜杰教授科研团队

杜杰教授，1985年毕业于北京大学生物系，1989年赴美国留学。先后作为博士后、助理教授、副教授在美国Emory University School of Medicine, Baylor College of Medicine从事心血管，高血压发生及其危害，肿瘤方面的研究。曾主持及参与多项美国NIH R01心血管研究课题。于2008年回国任教育部长江特聘教授，同年获得国家自然科学基金杰出青年称号。2010年任教育部心血管重塑相关疾病重点实验室主任，2011年任教育部长江创新主动脉瘤研究团队主任。目前任北京安贞医院院长助理，北京市心肺血管疾病研究所副所长，教授，主持包括国家“973”课题，北京市心血管病理生理平台课题，国家自然科学基金重大、重点等基金。累计发表SCI论文120余篇。杜杰教授目前担任中华医学会心血管分会基础组副组长、中华生理学会循环生理专业委员会副主任委员、中国动脉粥样硬化委员会常委等。担任Cardiovascular Toxicology副主编，Arteriosclerosis, Thrombosis, and Vascular Biology副主编，Cardiovascular Drugs and Therapy编委，Frontiers in Vascular Physiology编委，《中华分子心脏病学》副主编，《中国动脉硬化杂志》编委，《临床心血管病杂志》编委，《心肺血管疾病杂志》编委，《中华高血压杂志》编委，《转化医学杂志》编委等。

近五年发表文章：

1.Xiaogang Peng, Zhicheng Xiao, Jing Zhang, Yulin Li, Yanjun Dong, Jie Du: IL-17A produced by both γδ T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction. The Journal of Pathology. 2015; 235(1):79-89.

2.Zhicheng Xiao, Jing Zhang, Xiaogang Peng, Yanjun Dong, Lixin Jia, Huihua Li,Jie Du: The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. The international journal of biochemistry & cell biology.2014;55:65-71.

3.Aiping Lan, Yongfen Qi, Jie Du: Akt2 Mediates TGF-β1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3β/Snail Signaling Pathway in Renal Tubular Epithelial Cells. Cell Physiol Biochem. 2014; 34(2):368-82.

4.Ping Li, Yu-Lin Li, Zhen-Ya Li, Yi-Na Wu, Cong-Cong Zhang, Xi A, Chun-Xiao Wang, Hong-Tao Shi, Mi-Zhou Hui, Bo Xie, Mohammed Ahmed, Jie Du: Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1β/Interleukin-18 Signaling Promotes Vein Graft Thickening. Arteriosclerosis Thrombosis and Vascular Biology.2014;34(9):2001-11.

5.Jixin Zhong, Qilin Yu, Ping Yang, Xiaoquan Rao, Long He, Jing Fang, Yaqin Tu, Zhijun Zhang, Qiaohong Lai, Shu Zhang, Michal Kuczma, Piatr Kraj, Jun-Fa Xu, Feili Gong, Jianfeng Zhou, Li Wen, Decio L Eizirik, Jie Du, Wei Wang, Cong-Yi Wang: MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis. Journal of autoimmunity. 2014;53:95-104.

6.Yu Liu, Hui Yang, Lina Song, Nan Li, Qiu-Yue Han, Cui Tian, Erhe Gao, Jie Du, Yun-Long Xia, Hui-Hua Li: AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis. Apoptosis.2014;19(8):1254-68.

7.Aiping Lan, Jie Du: Potential role of Akt signaling in chronic kidney disease. Nephrol Dial Transplant. 2015;30(3):385-394.

8.Yueli Wang, Yulin Li, Yina Wu, Lixin Jia, Jijing Wang, Bo Xie, Mizhou Hui, Jie Du: TNF-α and IL-1β Neutralization Ameliorates Angiotensin II-Induced Cardiac Damage in Male Mice. Endocrinology.2014;155(7):2677-87.

9.Yulin Li, Yina Wu, Congcong Zhang, Ping Li, Wei Cui, Jianlei Hao, Xinliang Ma, Zhinan Yin, Jie Du: γδT Cell-Derived Interleukin-17A via an Interleukin-1β-Dependent Mechanism Mediates Cardiac Injury and Fibrosis in Hypertension. Hypertension.2014;64(2):305-14.

10.Xin Xi, Shuang Liu, Hongtao Shi, Min Yang, Yongfen Qi, Jian Wang, Jie Du: Serum-Glucocorticoid Regulated Kinase 1 Regulates Macrophage Recruitment and Activation Contributing to Monocrotaline-Induced Pulmonary Arterial Hypertension. Cardiovascular toxicology.2014;14(4):368-78.

11.Congcong Zhang, Yulin Li, Chunxiao Wang, Yina Wu, Wei Cui, Takashi Miwa, Sayaka Sato, Huihua Li, Wen-Chao Song, Jie Du: Complement 5a Receptor Mediates Angiotensin II-Induced Cardiac Inflammation and Remodeling. Arteriosclerosis Thrombosis and Vascular Biology.2014;34(6):1240-8.

12.M Yang, J-H Shao, Y-J Miao, W Cui, Y-F Qi, J-H Han, X Lin, J Du: Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. Cell death and differentiation.2014;21(8):1290-302.

13.Yina Wu, Yulin Li, Congcong Zhang, Xi A, Yueli Wang, Wei Cui, Huihua Li, Jie Du: S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury. Hypertension.2014;63(6):1241-50.

14.Luping Huang, Tatiana Belousova, Jenny Szu-Chin Pan, Jie Du, Huiming Ju, Lianghao Lu, Pumin Zhang, Luan D Truong, Alli Nuotio-Antar, David Sheikh-Hamad: AKI after Conditional and Kidney-Specific Knockdown of Stanniocalcin-1. Journal of the American Society of Nephrology.2014;25(10):2303-15.

15.Guan-Ming Qi, Li-Xin Jia, Yu-Lin Li, Hui-Hua Li, Jie Du: Adiponectin Suppresses Angiotensin II-Induced Inflammation and Cardiac Fibrosis through Activation of Macrophage Autophagy. Endocrinology.2014; 155(6):2254-65.

16.Feifei Ma, Jin Feng, Chao Zhang, Yulin Li, Guanming Qi, Huihua Li, Yuzhang Wu, Yangxin Fu, Yang Zhao, Hairong Chen, Jie Du, Hong Tang: The Requirement of CD8+ T Cells To Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure. The Journal of Immunology.2014;192(7):3365-73.

17.Min Yang, Jingwei Liu, Jianghua Shao, Yanwen Qin, Qunsheng Ji, Xiaolin Zhang, Jie Du: Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization. Molecular Cancer.2014;13:43.

18.Shu-Lan Qiu, Zhi-Cheng Xiao, Chun-Mei Piao, Ying-Lin Xian, Li-Xin Jia, Young-Fen Qi, Jiahuai Han, You-Yi Zhang, Jie Du: AMP-Activated Protein Kinase α2 Protects Against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-Induced Oxidative Stress. Journal of Biological Chemistry.2014;289(13):9449-59.

19.Ping Liang, Jie DU: Human induced pluripotent stem cell for modeling cardiovascular diseases. Regenerative Medicine Research. 02/2014; 2(4).

20.Chen Chen, Yan Meng, Lei Wang, Hong-Xia Wang, Cui Tian, Guo-Dong Pang, Hui-Hua Li, Jie Du: Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways. Immunology.2014;142(2):307-19.

21.Zhicheng Xiao, Jing Zhang, Junmeng Zhang, Lüya Wang, Jie Du: [Involvement of chemokine CXCL16 in myocardial infarction and its influence on phagocyticactivity of macrophage in vitro].. Zhonghua yi xue za zhi.2014;94(3):218-22.

22.Congcong Zhang, Yulin Li, Chunxiao Wang, Yina Wu, Jie Du: Antagonist of C5aR Prevents Cardiac Remodeling in Angiotensin II-Induced Hypertension. American Journal of Hypertension.2014;27(6):857-64.

23.Wei Zhao, Yulin Li, Lixin Jia, Lili Pan, Huihua Li,Jie Du: Atg5 Deficiency-Mediated Mitophagy Aggravates Cardiac Inflammation and Injury in Response to Angiotensin II. Free Radical Biology & Medicine.2014;69:108-15.

24.Aiping Lan, Jing Zhang, Zhicheng Xiao, Xiaogang Peng, Yongfen Qi, Jie Du: Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction. PLoS ONE.2014;9(8):e105451.

25.Rong Liu, Xin Liu, Phyllis C Zee, Lifang Hou, Zheng Zheng, Yongxiang Wei, Jie Du: Association between Sleep Quality and C-Reactive Protein: Results from National Health and Nutrition Examination Survey, 2005-2008. PLos One.2014;9(3):e92607.

26.Hong-Tao Shi, Ying Wang, Li-Xin Jia, Yan-Wen Qin, Yan Liu, Hui-Hua Li, Yong-Fen Qi, Jie Du: Cathepsin S Contributes to Macrophage Migration via Degradation of Elastic Fiber Integrity to Facilitate Vein Graft Neointimal Hyperplasia. Cardiovascular Research.2014;101(3):454-63.

27.Lei Wang, Yu-Lin Li, Cong-Cong Zhang, Wei Cui, Xia Wang, Yong Xia, Jie Du, Hui-Hua Li: Inhibition of Toll-Like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation. Cardiovascular Research.2014;101(3):383-92.

28.Lina Song, Hui Yang, Hong-Xia Wang, Cui Tian, Yu Liu, Xiang-Jun Zeng, Erhe Gao, Yu-Ming Kang, Jie Du, Hui-Hua Li: Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways. Apoptosis.2014;19(4):567-80.

29.Jiao Zheng, Min Yang, Jianghua Shao, Yanju Miao, Jiahuai Han,Jie Du: Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Molecular Cancer.2013;12(1):141.

30.Jie Du, Janet D Klein, Faten Hassounah, Jing Zhang, Cong Zhang, Xiaonan H Wang: Aging increases CCN1 expression leading to muscle senescence. AJP Cell Physiology.2014;306(1):C28-36.

31.Xia Wang, Jie Du, Hui-Hua Li: [The role of miRNA-155 in cardiovascular diseases]. Sheng li ke xue jin zhan. 2013;44(5):377-80.

32.Hong-Xia Wang, Hui Yang, Qiu-Yue Han, Nan Li, Xue Jiang, Cui Tian, Jie Du, Hui-Hua Li: NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy. Free Radical Biology & Medicine.2013;65:897-907.

33.Li-Xin Jia, Guan-Ming Qi, Ou Liu, Tao-Tao Li, Min Yang, Wei Cui, Wen-Mei Zhang, Yong-Fen Qi, Jie Du: Inhibition of Platelet Activation by Clopidogrel Prevents Hypertension-Induced Cardiac Inflammation and Fibrosis. Cardiovascular Drugs and Therapy.2013;27(6):521-30.

34.Hui-Min Jiang, Hong-Xia Wang, Hui Yang, Xiang-Jun Zeng, Chao-Shu Tang, Jie Du, Hui-Hua Li: Role for Granulocyte Colony Stimulating Factor in Angiotensin II-Induced Neutrophil Recruitment and Cardiac Fibrosis in Mice. American Journal of Hypertension.2013 ;6(10):1224-33.

35.Yanwen Qin, Yaoguo Yang, Rong Liu, Xu Cao, Ou Liu, Jing Liu, Miao Wang, Ya Yang, Zhong Chen, Hongjia Zhang, Jie Du: Combined serum Cathepsin S and hs-CRP levels predicting inflammatory activity of Abdominal Aortic Aneurysm lesions. Clinical biochemistry. 2013; 46(12):1026-9.

36.Jie Du, Lixin Jia, Yulin Li, Xinliang Ma: Add Another Killer for Interfered Vascular Function: Natural Killer Cells-Produced Interferon-γ Is a Cue. Arteriosclerosis Thrombosis and Vascular Biology. 2013;3(6):33(6):1116-7.

37.Xiao-Hui Duan, Jin-Rui Chang, Jing Zhang, Bao-Hong Zhang, Yu-Lin Li, Xu Teng, Yi Zhu, Jie Du, Chao-Shu Tang, Yong-Fen Qi: Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification. Apoptosis. 2013;18(9):1132-44. 

38.Hua Xue, Zhicheng Xiao, Jing Zhang, Jun Wen, Yuan Wang, Zai Chang, Jing Zhao, Xiang Gao, Jie Du, Ye-Guang Chen: Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. Journal of Biological Chemistry. 2013;288(21):15006-14.

39.Yan-Wen Qin, Xu Teng, Ji-Qiang He, Jie Du, Chao-Shu Tang, Yong-Fen Qi: Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome. Peptides. 2013;42:84-8.

40.Juan Lin, Hanjie Li, Min Yang, Junming Ren, Zhe Huang, Felicia Han, Jian Huang, Jianhui Ma, Duanwu Zhang, Zhirong Zhang, Jianfeng Wu, Deli Huang, Muzhen Qiao, Guanghui Jin, Qiao Wu, Yinghui Huang, Jie Du, Jiahuai Han: A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Reports. 2013;3(1):200-10.

41.Yong Zeng, Hong-Xia Wang, Shu-Bin Guo, Hui Yang, Xiang-Jun Zeng, Quan Fang, Chao-Shu Tang, Jie Du, Hui-Hua Li: Transcriptional Effects of E3 Ligase Atrogin-1/MAFbx on Apoptosis, Hypertrophy and Inflammation in Neonatal Rat Cardiomyocytes. PLoS ONE. 2013;8(1):e53831.

42.Jun-Meng Zhang, Ying Wang, Yan-Ju Miao, Yi Zhang, Yi-Na Wu, Li-Xin Jia, Yong-Fen Qi, Jie Du: Knockout of CD8 Delays Reendothelialization and Accelerates Neointima Formation in Injured Arteries of Mouse via TNF-α Inhibiting the Endothelial Cells Migration. PLoS ONE. 2013;8(5):e62001.

43.Fuli Zhu, Yulin Li, Junmeng Zhang, Chunmei Piao, Tingting Liu, Hui-Hua Li, Jie Du: Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction. PLoS ONE. 2013;8(9):e74535.

44.Yi Zhang, Ying Wang, Yan Liu, Nanping Wang, Yongfen Qi, Jie Du: Krüppel-Like Factor 4 Transcriptionally Regulates TGF-β1 and Contributes to Cardiac Myofibroblast Differentiation. PLoS ONE. 2013;8(4):e63424.

45.Kui Zhang, Jian Cao, Ran Dong, Jie Du: Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft. Oxidative Medicine and Cellular Longevity. 2013;2013:432409. 

46.Yue-Hong Zheng, Fang-Da Li, Cui Tian, Hua-Liang Ren, Jie Du, Hui-Hua Li: Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms. PLoS ONE. 2013;8(12):e83310.

47.Yan Meng, Chen Chen, Lei Wang, Xia Wang, Cui Tian, Jie Du, Hui-Hua Li: Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway. Cellular Physiology and Biochemistry. 2013;32(4):1097-105.

48.Yun Lin, Zhi Zhong Li, Jingmei Zhang, Jinrong Zhang, Qian Fan, Jie Du: Aging might increase the incidence of infection from permanent pacemaker implantation. Oxidative Medicine and Cellular Longevity. 2013;2013:943416.

49.Yang SW, Zhou YJ, Tian XF, Pan GZ, Liu YY, Zhang J, Guo ZF, Chen SY, Gao ST, Du J, Jia DA, Fang Z, Hu B, Han HY, Gao F, Hu DY, Xu YY, Beijing Heart, Metabolism Survey Study Group: Association of dysglycemia and all-cause mortality across the spectrum of coronary artery disease. Mayo Clinic Proceedings. 2013;88(9):930-41. 

50.Congcong Zhang, Yulin Li, Yina Wu, Luya Wang, Xiaonan Wang, Jie Du: Interleukin-6/STAT3 pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration. Journal of Biological Chemistry. 2013;288(3):1489-99.

51.Yanwen Qin, Xu Cao, Jun Guo, Yaozhong Zhang, Lili Pan, Hongjia Zhang, Huihua Li, Chaoshu Tang, Jie Du, Guo-Ping Shi: Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovascular Research. 2012;96(3):401-10.

52.Kun Yang, Tian-Peng Zhang, Cui Tian, Li-Xin Jia, Jie Du, Hui-Hua Li: Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling. American Journal of Hypertension. 2012;25(9):994-1001.

53.Anlin Liang, Yun Wang, Lauren E Woodard, Matthew H Wilson, Rajendra Sharma, Yogesh C Awasthi, Jie Du, William E Mitch, Jizhong Cheng: Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. The Journal of Pathology. 2012;228(4):448-58. 

54.Min Yang, Jiao Zheng, Yanjv Miao, Ying Wang, Wei Cui, Jun Guo, Shulan Qiu, Yalei Han, Lixin Jia, Huihua Li, Jizhong Cheng,Jie Du: Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arteriosclerosis Thrombosis and Vascular Biology. 2012;32(7):1675-86. 

55.Yulin Li, Congcong Zhang, Yina Wu, Yalei Han, Wei Cui, Lixin Jia, Lun Cai, Jizhong Cheng, Huihua Li, Jie Du: Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis. Arteriosclerosis Thrombosis and Vascular Biology. 2012;32(7):1662-74.

56.Lixin Jia, Yulin Li, Chuanshi Xiao, Jie Du: Angiotensin II induces inflammation leading to cardiac remodeling. Frontiers in Bioscience. 2012;17:221-31.

57.Feifei Ma, Yulin Li, Lixin Jia, Yalei Han, Jizhong Cheng, Huihua Li, Yongfen Qi, Jie Du: Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS ONE. 2012;7(5):e35144.

58.Lili Pan, Yulin Li, Lixin Jia, Yanwen Qin, Guanming Qi, Jizhong Cheng, Yongfen Qi, Huihua Li, Jie Du: Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. PLoS ONE. 2012;7(4):e35315.

59.Ya-lei Han, Yu-lin Li, Li-xin Jia, Ji-zhong Cheng, Yong-fen Qi, Hong-jia Zhang, Jie Du: Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis. PLoS ONE. 2012;7(5):e35506. 

60.Ou Liu, Lixin Jia, Xiaoxi Liu, Yueli Wang, Xiaolong Wang, Yanwen Qin, Jie Du, Hongjia Zhang: Clopidogrel, a Platelet P2Y12 Receptor Inhibitor, Reduces Vascular Inflammation and Angiotensin II Induced-Abdominal Aortic Aneurysm Progression. PLoS ONE. 2012;7(12):e51707. 

61.Ye-bo Zhou, Jing Zhang, Yan Cai, Xu Teng, Xiao-hui Duan, Jun-qiu Song, Jie Du, Chao-shu Tang, Yong-fen Qi: Insulin resistance induces medial artery calcification in fructose-fed rats. Experimental Biology and Medicine. 2012;237(1):50-7.

62.Liping Zhang, Yanjun Dong, Yanlan Dong, Jizhong Cheng, Jie Du: Role of integrin-β3 protein in macrophage polarization and regeneration of injured muscle. Journal of Biological Chemistry. 2012;287(9):6177-86.

63.Liping Zhang, Yanjun Dong, Yanlan Dong, Jizhong Cheng, Jie Du: The Role of Integrin-β3 in Macrophage Polarization and Regeneration of Injured Muscle. The Journal of Biological Chemistry. 2012;287(9):6177-86.

64.Jizhong Cheng, Yun Wang, Anlin Liang, Lixin Jia, Jie Du: FSP-1 silencing in bone marrow cells suppresses neointima formation in vein graft. Circulation Research. 2012;110(2):230-40.

65.Ying Wang, Beilei Zhao, Yi Zhang, Zhihui Tang, Qiang Shen, Youyi Zhang, Weizhen Zhang, Jie Du, Shu Chien, Nanping Wang: Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury. British Journal of Pharmacology. 2012;165(7):2378-88.

66.Hui Yang, Xiang-Jun Zeng, Hong-Xia Wang, Li-Ke Zhang, Xiao-Li Dong, Shubin Guo, Jie Du, Hui-Hua Li, Chao-Shu Tang: Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor. Peptides. 2011;32(10):2108-15.

67.Xu Teng, Junqiu Song, Gaigai Zhang, Yan Cai, Fang Yuan, Jie Du, Chaoshu Tang, Yongfen Qi: Inhibition of endoplasmic reticulum stress by intermedin(1-53) protects against myocardial injury through a PI3 kinase-Akt signaling pathway. Journal of Molecular Medicine. 2011;89(12):1195-205.

68.Gang Chen, Song-Chang Lin, Jiyuan Chen, Liqun He, Feixia Dong, Jing Xu, Shuhua Han, Jie Du, Mark L Entman, Yanlin Wang: CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. Journal of the American Society of Nephrology. 2011;22(10):1876-86.

69.Weiming Li, Rong Rong, Sheng Zhao, Xiaoming Zhu, Ke Zhang, Xin Xiong, Xueqing Yu, Qinghua Cui, Shuqiang Li, Li Chen, Jun Cai, Jie Du: Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure. Journal of Cellular and Molecular Medicine. 2012;16(1):59-71.

70.Guanming Qi, Lixin Jia, Yulin Li, Yunfei Bian, Jizhong Cheng, Huihua Li, Chuanshi Xiao, Jie Du: Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent. Cardiovascular toxicology. 2011;11(2):157-67.

71.Jingyuan Ren, Min Yang, Guanming Qi, Jiao Zheng, Lixin Jia, Jizhong Cheng, Cui Tian, Huihua Li, Xin Lin, Jie Du: Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. American Journal of Hypertension. 2011;24(6):701-7.

72.Yue-Hong Zheng, Cui Tian, Yan Meng, Yan-Wen Qin, Ya-Hao Du, Jie Du, Hui-Hua Li: Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. Journal of Cellular Physiology. 2012;227(1):127-35.

73.Hui-Hua Li, Jie Du, Yong-Na Fan, Mei-Li Zhang, De-Pei Liu, Luge Li, Pamela Lockyer, Eunice Y Kang, Cam Patterson, Monte S Willis: The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. American Journal Of Pathology. 2011;178(3):1043-58.

74.Liping Zhang, Vik Rajan, Eugene Lin, Zhaoyong Hu, H Q Han, Xiaolan Zhou, Yanping Song, Hosung Min, Xiaonan Wang, Jie Du, William E Mitch: Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. The FASEB Journal. 2011;25(5):1653-63.

75.Yuan Zhang, Yong Zeng, Min Wang, Cui Tian, Xu Ma, Houzao Chen, Quan Fang, Lixin Jia, Jie Du, Huihua Li: Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Archiv für Kreislaufforschung. 2011;106(3):371-83.

76.Shi-Wei Yang, Yu-Jie Zhou, Xiao-Min Nie, Yu-Yang Liu, Jie Du, Da-Yi Hu, De-An Jia, Fei Gao, Bin Hu, Zhe Fang, Hong-Ya Han, Xiao-Li Liu, Zhen-Xian Yan, Jian-Long Wang, Qi Hua, Yu-Jie Shi, Hong-Wei Li: Effect of abnormal fasting plasma glucose level on all-cause mortality in older patients with acute myocardial infarction: results from the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS). Mayo Clinic Proceedings. 2011; 86(2):94-104.

77.Yuan Zhang, Yu-Ming Kang, Cui Tian, Yong Zeng, Li-Xin Jia, Xu Ma, Jie Du, Hui-Hua Li: Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice. PLoS ONE. 2011;(6):e21104.

78.Jun-Jie Li, Tian-Peng Zhang, Yan Meng, Jie Du, Hui-Hua Li: Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells. Cellular Physiology and Biochemistry. 2011; 27(5):463-70.

79.Dong Zhao, Yue Qi, Zheng Zheng, Ying Wang, Xiu-Ying Zhang, Hong-Juan Li, Hai-Hang Liu, Xiao-Ting Zhang, Jie Du, Jing Liu: Dietary factors associated with hypertension. Nature Reviews Cardiology. 2011;8(8):456-65.

80.Jizhong Cheng, Luan D Truong, Xiaoqian Wu, Dietmar Kuhl, Florian Lang, Jie Du: Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney International. 2010;78(7):668-78.

81.Yan-wen Qin, Ping Ye, Ji-qiang He, Li Sheng, Lu-ya Wang, Jie Du: Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ and reducing TC, MMP-9, and Cat S levels. Acta Pharmacologica Sinica. 2010;31(10):1350-8.

82.Ou Liu, Jian-rong Li, Ming Gong, Ming Xu, Jie Du, Hong-jia Zhang: Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population. Acta Pharmacologica Sinica. 2010;31(10):1376-80.

83.Shu Liu, Hua Shen, Ming Xu, Ou Liu, Limin Zhao, Sa Liu, Zhenheng Guo, Jie Du: FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. AJP Endocrinology and Metabolism. 2010;299(3):E351-63.

84.Sandra B Haudek, Jizhong Cheng, Jie Du, Yanlin Wang, Jesus Hermosillo-Rodriguez, JoAnn Trial, George E Taffet, Mark L Entman: Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 2010; 49(3):499-507.

85.Jizhong Cheng, Ying Wang, Yewei Ma, Bonita Tak-yee Chan, Min Yang, Anlin Liang, Liping Zhang, Huihua Li, Jie Du: The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. Circulation Research. 2010;107(10):1265-74.

86.Xiaonan H Wang, Liping Zhang, William E Mitch, Joseph M LeDoux, Junping Hu, Jie Du: Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity. Journal of Biological Chemistry. 2010;285(28):21249-57.

87.Junping Hu, Jie Du, Liping Zhang, S Russ Price, Janet D Klein, Xiaonan H Wang: XIAP reduces muscle proteolysis induced by CKD. Journal of the American Society of Nephrology. 2010;21(7):1174-83.

88.Zhaoyong Hu, Huiling Wang, In Hee Lee, Swati Modi, Xiaonan Wang, Jie Du, William E Mitch: PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes. 2010;59(6):1312-20.

89.Liping Zhang, Xiaonan H Wang, Huiling Wang, Jie Du, William E Mitch: Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy. Journal of the American Society of Nephrology. 2010;21(3):419-27.

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