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TheBrainMechanismsandFunctionalHypothesisofDefaultModeNetwork
andItsClinicalApplication
LIYu;SHUHua
(NationalKeyLaboratoryofCognitiveNeuroscienceandLearning,BeijingNormalUniversity,Beijing100875,China)
Abstract:Rapiddevelopmentofcognitiveneurosciencemakesscientistshaveadeepunderstandingabout
humanbrainfunction.Inrecentyears,thedeactivationphenomenoninsomebrainareaswascommonly
observedwhenparticipantswererequiredtoexecuteexternaldemandingtasks,andhencetheconceptof
―DefaultModeNetwork(DMN)‖wasputforward,andhasattractedmoreandmoreattentionfromcognitive
neuroscientists.CurrentreviewmainlyfocusedonthehistoryofDMNresearch,therelevantconceptsand
theories,ontogeneticandphylogeneticdevelopment,thediseasesassociatedwithanditsclinicalapplication.
ItsuggeststhatfuturestudiescomprehensivelyinvestigateDMNfromdevelopmenttrajectory,individual
andspeciesdifferences,therelationshipswithotherbrainnetworks(e.g.,attentionnetwork,visualnetwork,
executivecontrolnetwork),anditsassociationswithdiseases.
Keywords:defaultmodenetwork;deactivation;functionalconnectivity;clinicalapplication
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