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This study was undertaken to elucidate the role of macrophage-expressed IL-37
in reducing the production and effects of proinflammatory cytokines,
preventing foam cell formation, and reducing the development of atherosclerosis. Feedback regulatory circuits provided by regulatory T cells (Treg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Mammals have a sophisticated immune system that does the tricky job of rejecting the harmful non-self and tolerating microbial friends without reacting to its own constituents. Mammals have a sophisticated immune system that does the tricky job of rejecting the harmful non-self and tolerating microbial friends without reacting to its own constituents. Incapacitation of the immune system through genetic mutation and exposure to radiation or chemotherapy, among other factors, can lead to life-threatening infections. Lack of regulation, on the contrary, leads to inflammation and autoimmunity. the immune system relies on effector immune responses tailored to eradicate particular pathogens, as well as feedback regulatory circuits provided by regulatory T cells (Treg cells) and suppressive cytokines. It took half a century to show that the immune system can be actively and specifically silenced or made tolerant. The IL-1 family of cytokines encompasses 11 proteins that share a similar β-barrel structure. IL-1家族的细胞因子包含11种蛋白质，它们具有相似的β筒壁结构。 In contrast, IL-1 receptor antagonist (IL-1RA or IL-1F3) and the receptor antagonist that binds to（与---结合） the receptor IL-1Rrp2 (IL-36Ra or IL-1F5) diminish inflammation by blocking the binding of the agonist receptor ligands. The biological role of IL-37 (IL-1F7) is just starting to be elucidated |
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