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作者：生物谷来源：生物谷2009-2-6 16:40:51
吴瑛，博士。美国西北大学讲席教授。 1980－1986年上海医科大学医学士，1986－1991年美国斯坦福大学肿瘤生物学博士，1991－1994年哈佛大学生物化学和分子生物学系博士后。先后任教于华盛顿大学医学院、范德比尔特大学医学中心、西北大学神经生物学系。 曾获美国白血病学会连续十二年资助（从博士后、特别研究员到学者奖）。为Science、Nature、Cell、MCB、PNAS等15个杂志审稿，为美国国立健康研究院、老年痴呆基金会、加拿大医学研究委员会、意大利Telethon基金会等评审基金。在哈佛大学参与生物化学教学、在华盛顿大学参与核酸与蛋白质、细胞生物学博士生课程教学, 在英国剑桥、美国哈佛大学、宾州大学、布朗大学等做过学术报告。1998年起兼上海医科大学教授。曾获上海医科大学一等奖（1986年）和国家杰出青年科学基金（1998年）， 2001年起参与中国科学院上海生命科学研究院分子生物学研究生课程教学。研究领域：mRNA剪接、神经退行性病变的分子机理和白细胞迁移。 # # # 代表论文： 1: Moodley Y, Linz B, Yamaoka Y, Windsor HM, Breurec S, Wu JY, Maady A, Bernh?ft S, Thiberge JM, Phuanukoonnon S, Jobb G, Siba P, Graham DY, Marshall BJ, Achtman M.(2009)The peopling of the Pacific from a bacterial perspective.Science. 323(5913):527-30. 2:Fushimi K, Ray P, Kar A, Wang L, Sutherland LC, Wu JY.(2008)Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.Proc Natl Acad Sci U S A. 105(41):15708-13. 3:Wang C, Norton JT, Ghosh S, Kim J, Fushimi K, Wu JY, Stack MS, Huang S.(2008)Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner.J Biol Chem. 283(29):20277-87. 4:Havlioglu N, Wang J, Fushimi K, Vibranovski MD, Kan Z, Gish W, Fedorov A, Long M, Wu JY.(2007)An intronic signal for alternative splicing in the human genome.PLoS ONE. 2(11):e1246. 5:Yang YC, Ho TC, Chen SL, Lai HY, Wu JY, Tsao YP.(2007)Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.BMC Cancer.7:216. 6:Yang G, Huang SC, Wu JY, Benz EJ Jr.(2008)Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.Blood.111(1):392-401. 7:Altay T, McLaughlin B, Wu JY, Park TS, Gidday JM.(2007)Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia.Exp Neurol.207(2):186-94. 8:Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY.(2007)Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa.Neurobiol Dis.26(2):291-300. 9:Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P Jr, Wu JY.(2006)Pre-mRNA splicing and retinitis pigmentosa.Mol Vis.12:1259-71. 10:Wu JY, Kar A, Kuo D, Yu B, Havlioglu N.(2006)SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.Mol Cell Biol.26(18):6739-47. 11:Li X, Chen Y, Liu Y, Gao J, Gao F, Bartlam M, Wu JY, Rao Z.(2006)Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.J Biol Chem.281(38):28430-7. 12:Donahue CP, Muratore C, Wu JY, Kosik KS, Wolfe MS.(2006)Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.J Biol Chem. 281(33):23302-6. 13:Kar A, Havlioglu N, Tarn WY, Wu JY.(2006)RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.J Biol Chem.281(34):24479-88. 14:Kar A, Kuo D, He R, Zhou J, Wu JY.(2005)Tau alternative splicing and frontotemporal dementia.Alzheimer Dis Assoc Disord. Oct-Dec;19 Suppl 1:S29-36. Review. 15:Yuan L, Kawada M, Havlioglu N, Tang H, Wu JY.(2005)Mutations in PRPF31 inhibit pre-mRNA splicing of rhodopsin gene and cause apoptosis of retinal cells.J Neurosci.25(3):748-57. 16:Chen B, Blair DG, Plisov S, Vasiliev G, Perantoni AO, Chen Q, Athanasiou M, Wu JY, Oppenheim JJ, Yang D.(2004)Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.J Immunol. 173(10):5914-7. 17:Yang G, Huang SC, Wu JY, Benz EJ Jr.(2005)An erythroid differentiation-specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer.Blood.105(5):2146-53. |
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