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*本文译自Mark Hyman医生的文章 Imagine being the parent of a young child who is not acting normally andbeing told by your doctor that your child has autism, that there is no known cause, and there is no known treatment except,perhaps, some behavioral therapy. That is exactly what Jackson's parents weretold as their 22-month-old son regressed into the non-verbal psychic prison ofsocial withdrawal, disconnection, and repetitive behaviors typical of autism. 假如你有一个表现异常的小孩, 医生告诉你他得了自闭症, 却查不到病因, 除了一些行为疗法, 就再也想不到其它治疗方法—— 这就是Jackson的父母的真实遭遇.。他们的儿子才22个月大,患了自闭症,其典型症状是: 社会性退缩, 不与人沟通和重复动作。 While we don't have all the answers, and more research is needed to identify and validate the causes and treatment of autism, there are new signs of hope. A study just published in TheJournal of the American Medical Association by researchers from the Universityof California, Davis called 'Mitochondrial Dysfunction inAutism' (i) discovered aprofound and serious biological underpinning of autism -- an acquiredloss of the ability to produce energy in the cells, damage to mitochondria (the energy factories in your cells), and an increase in oxidative stress (the same chemical reaction that causes cars to rust, apples to turn brown, fat to become rancid, and skin to wrinkle). These disturbances in energy metabolism were not due to genetic mutations, which is often seen in mitochondrial problems, but acondition the children studied acquired in utero or after birth. 正当我们不知道怎样去解决, 需要更多的研究去辨明病因,找出治疗方法的时候, 希望之光出现了。在《美国医学会期刊》上,来自加州大学戴维斯分校的研究人员刚发表了一篇名为《自闭症线粒体功能障碍》的报告, 它发现自闭症有着深层的生物原因---细胞不能产生能量, 线粒体受损(细胞内的能量工厂), 氧化应激增加(和汽车生锈,苹果成熟, 油脂变臭和皮肤起皱纹的化学反应是一样的)。这些能量新陈代谢中的紊乱问题不是由基因突变引起的, 基因突变通常只发生在线粒体内, 但是根据研究,有些小孩在胎儿时期或出生后也会有这些紊乱问题。 Bottom line, if brain cells cannot produce enough energy, and there is too muchoxidative stress, then neurons don't fire, connections aren't made and the lights don't go on for these children. In fact, this problem of energy loss is found in most chronic disease and aging -- from diabetes to heart disease to dementia. Brain function and neurodevelopment in particular are highly dependent on energy. 总之, 如果脑细胞不能产生足够的能量, 氧化应激过多, 神经元就不能完成“点火”工作，没有连接，孩子们就没有机会接近“灯光”。事实上，能量损失在很多慢性病和老龄化过程中都会出现——从糖尿病到心脏病到痴呆症，但是大脑功能和神经发育却高度依赖能量。 This is exactly the problem, I documented and found in Jackson when I first saw him.He had a profound loss of energy in his cells (particularly his brain cells), and indicators of severe oxidative stress. This is the same problem many other researchers have found in similar studies. (ii) Despite the evidence, most physicians don't test for mitochondrial dysfunction,oxidative stress or other myriad factors commonly found in autistic children. 第一次看到Jackson，我就发现了这个问题。他的细胞有着严重的能量损失（尤其是脑细胞），还有氧化应激的症状。这也是其它研究人员在相似的研究中发现的问题。尽管这些迹象很明显，很多医生还是没有给自闭小孩测试线粒体功能障碍，氧化应激和其它常见的症状。 Let's look more closely at what this new study in The Journal of the American Medical Association tells us about mitochondrial dysfunction, and how this may lead us to new methods of treatment -- methods similar to the ones I used to help reverse Jackson's autism. 让我们更深入地看待这个新研究，看看《美国医学会期刊》给我们提供了哪些有关线粒体机能障碍的信息，以及我们会根据这些信息找到那些新的治疗方法——这些方法和我帮助Jackson医治自闭症用的方法很相似。 Autism: BrainDisorder or Body-Based Biological Illness? 自闭症：脑失调还是身体疾病？ 关于自闭症，一直都有一个争议——自闭症是由大脑引起的固定的，不可医治的遗传紊乱？还是一种身体引起的系统的，可医治的生理状态？后者有明显的病因和异常情况，机能障碍可以治好。换一句话说就是，自闭症是否可以治好？ Many studies have illuminated the causes and possible treatments for autism, but main stream physicians or scientists ignore most of this data. This new study, breaks newground because it was published in one of the world's major medical journals. 很多研究已经把自闭症的病因和可行治疗方法列出来了，但是主流医生和科学家都没有理会这些数据。这项新研究是个例外，因为它能发表在世界著名的医学期刊上面。 In it researchers from UCD avis examined children two to five years of age from the Childhood Autism RiskFrom Genes and Environment (CHARGE) study in California -- a population-based,case-control investigation with confirmed autism cases and age-matched,genetically unrelated, typically developing controls, that was launched in 2003 and is still on going. What they discovered was the aforementioned mitochondrial dysfunction that lead to problems with energy. Interestingly, these abnormalities were not found in neurons on a brain biopsy but from examining white blood cells called lymphocytes. This means the energy deficit was asystemic problem -- not one residing solely in the brain. 在这篇报告里，来自加州大学戴维斯分校的研究人员测试了2到5岁的儿童，他们来自加州“由基因和环境引起的儿童自闭症”研究小组。这项调查从2003年开始，现在还在继续。它以地区人口为基础，采用病例对照的方法，选取了自闭症案例，还有与年龄相符，与基因无关，有针对性的控制。前面提到的由线粒体机能障碍引起的能量问题就是这项调查发现的。有趣的是，这些异常情况不是在活体检视时在“神经元”那里发现的，而是在检查叫做“淋巴细胞”的白细胞的时候发现的。这说明能量缺乏是系统问题——而不仅仅是大脑的问题。 This study forces the question: How do children acquire energy deficits that affect their whole system, not just the brain? 这项研究提出了一个问题：儿童是怎么患上不仅仅是影响大脑，而是整个系统的能量缺乏症状的呢？ The causes of mitochondrial dysfunction are well known, specifically as it relates to metabolism and thebrain, and I have documented them in my books 'Ultra Metabolism' and'The Ultra Mind Solution.' They include environmental toxins (iv) -- mercury, lead and persistent organic pollutants(v) -- latent infections, gluten and allergens (which trigger inflammation) sugar and processed foods,(vi) a nutrient-depleteddiet(vii) and nutritional deficiencies.(viii) These are all potentially treatable and reversible causes of mitochondrial dysfunction that have been clearly documented. 线粒体机能障碍的病因已经找到了，它尤其与新陈代谢和大脑相关，我已经把它们写进了我的书《过度新陈代谢》和《超意识解决方法》。它们包括了来自环境的毒素——水银、铅，难降解有机污染物——潜伏性感染，谷朊和过敏原（会引起发炎），糖和加工食品，没有营养的饮食和营养不良。这些都是有记录的引起线粒体机能障碍的原因，它们都是可以治疗的。 I found all these problemsin Jackson, and over a period of two years we slowly unraveled and treated the underlying causes of his energy loss which included gut inflammation, mercury,and nutrient deficiencies. Over time, the tests for his mitochondrial functionand oxidative stress (as well as levels of inflammation and nutrient status) all normalized. When they became normal, so did Jackson. He went fromfull-blown regressive autism to a normal, bright beautiful six-year-old boy. 这些问题Jackson身上都有，我们用了两年的时间慢慢地解决了他能量缺乏的潜在因素，包括肠炎、汞过量和营养不良。随着时间的流逝，测试发现他的线粒体功能和氧化应激慢慢恢复正常（以及发炎和营养程度）。当这些问题解决了之后，Jackson也慢慢地恢复了。他从一个完全的自闭症患者变回了一个正常、聪明漂亮的六岁小孩。 What it Means ifAutism Can be Reversed 自闭症能够痊愈代表着什么？ 这只是一个案例，但是如果一个小孩的自闭被治好了，如果有效的疗法是存在的，一些重要问题值得我们思考：这是怎么发生的？别的孩子能够痊愈吗？生理模式是什么？它们是怎么被治好的？ The emotional and financial costs of autism for families and societies is staggering. Now one in five -- or 20 percent -- of children have some neuro developmental disorder. How can we sidestep our scientific and moralobligation and sit back and accept the limited resources allocated by the National Institutes of Health ($5.1 billion for cancer, but only $141 million for autism) and society as a whole. 对家庭和社会而言，为自闭症付出的情绪和经济成本太大了。现在五分之一的小孩都有神经发育紊乱的问题。我们怎么可以袖手旁观，坐等美国国家卫生院那微薄的资金投入呢（投入癌症的资金是51亿，但投入到自闭症的只有1.41亿）？ Most neuro developmental disorders have common roots. But looking at only one aspect of such conditions will not solve the problem of autism. Current autism research is based on an outdated approach -- one that is something like blind men examining the proverbial elephant. Each researcher works in his or her own silo examining different factors and coming to different conclusions. Research that integrates, synthesizes and examines all the data on causes and potential treatments is practically non-existent. 很多神经发育紊乱都有着共同的根基，但是仅仅从一个方面入手是治不好自闭症的。现在的自闭症研究基于一个古老的疗法上，把它比喻成盲人摸象一点都不过分。研究者都各自研究各自的，得出的结论也不尽相同。完善、综合并测试所有与病因和可行疗法有关的数据的研究是不存在的。 The mitochondrial dysfunction identified in the JAMA study I've been talking about is ultimatelyonly one downstream symptom of many upstream causes. Other researchershave found systemic inflammation,(ix) brain inflammation,(x) gut inflammation,(xi) elevated levels of toxins and metals, gluten and casein antibodies,(xii) nutrient deficiencies including omega-3 fats,(xiii) vitamin D,(xiv) zinc, and magnesium, and collections of metabolic dysfunction relatedto quirky genes that make it difficult to perform chemical reactions essential for health in the body such as methylation and sulfation.(xv) 《美国医学会期刊》上面所提出的线粒体机能障碍，其实是很多因素积累而成的。其他研究人员发现了系统发炎、脑炎、肠炎、过度的毒素和金属、古朊和酪蛋白抗体、营养不良、缺少omega-3 脂肪、维生素D、锌和镁，和基因有关的新陈代谢机能不良严重阻碍了一些化学反应的进行，而这些化学反应对人体健康有重大影响，比如甲基化作用和硫酸盐化作用。 The take home message here is that the answer to autism and other neuro developmental disorders will not be found in one of these factors, but in all of them taken together in varying degrees in each individual. There is no such thing as 'autism.' Rather there are 'autisms'--different patterns of biological dysfunction unique to each child that resul in multiple insults to the brain that all manifest with symptoms we call autism. 我想强调的是，自闭症和其它神经发育紊乱的病因不会是这些因素中的单独一个，而是指它们都有份参与，只不过是对每个人的影响程度不同而已。没有叫做“自闭症”的东西，只有“自闭症群”---我们把对每个病患小孩独有的，对大脑造成很多影响的，有明显症状的生理机能障碍叫做“自闭”。 Future research mustsynthesize current data and design relevant whole systems research studies that don't focus on a single factor, but examine all the factors together. Then we must apply these findings in a comprehensive fashion, as is being done by many practitioners today who work in parallel -- rather than in collaboration with-- conventional approaches and often achieve remarkable results. 未来的研究一定要综合现有的数据，设计出全面系统的研究方案，而不是仅仅关注一个因素。然后全面应用这些发现，就跟现在很多人一样，没有采用传统方法，反而取得不错的成效。 To close, I'd like to share Jackson's story, as told by his father. I have documented this case report in a peer reviewed published paper which you can read if you are interested in the details of the case.(xvi) It is called 'Autism: Is it All in the Head?' and it can be found at http://. 我想拿Jackson的经历作为报告的结尾，这些经历都是他爸爸告诉我的。我已经把这个病例写在一篇已发表的论文里，这篇论文已经得到了同行的首肯。如果你对这个病例有兴趣的话，可以看看那篇论文，里面有很多细节。这篇论文叫做《自闭症：只是发生在大脑里吗？》你可以在这个网址http://.找到它。 But more important than my paper is Jackson's story and his beautiful smile. 但是比我的报告更重要的是Jackson的经历和他的微笑。 |
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