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LOCUS       NP_006538                579 aa            linear   PRI 26-NOV-2018
DEFINITION  insulin-like growth factor 2 mRNA-binding protein 3 [Homo sapiens].
ACCESSION   NP_006538
VERSION     NP_006538.2
DBSOURCE    REFSEQ: accession NM_006547.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Kim HY, Ha Thi HT and Hong S.
  TITLE     IMP2 and IMP3 cooperate to promote the metastasis of
            triple-negative breast cancer through destabilization of
            progesterone receptor
  JOURNAL   Cancer Lett. 415, 30-39 (2018)
   PUBMED   29217458
  REMARK    GeneRIF: Data show that insulin-like growth factor-II mRNA-binding
            protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis
            represents a double-negative feedback loop and serves as a new
            potential therapeutic target for the treatment of Triple-negative
            breast cancer (TNBC).
REFERENCE   2  (residues 1 to 579)
  AUTHORS   Elagib KE, Lu CH, Mosoyan G, Khalil S, Zasadzinska E, Foltz DR,
            Balogh P, Gru AA, Fuchs DA, Rimsza LM, Verhoeyen E, Sanso M, Fisher
            RP, Iancu-Rubin C and Goldfarb AN.
  TITLE     Neonatal expression of RNA-binding protein IGF2BP3 regulates the
            human fetal-adult megakaryocyte transition
  JOURNAL   J. Clin. Invest. 127 (6), 2365-2377 (2017)
   PUBMED   28481226
  REMARK    GeneRIF: IGF2BP3 as a human ontogenic master switch that restricts
            megakaryocyte development by modulating a lineage-specific P-TEFb
            activation mechanism.
REFERENCE   3  (residues 1 to 579)
  AUTHORS   Wei Q, Zhou H, Zhong L, Shi L, Liu J, Yang Q and Zhao T.
  TITLE     IMP3 expression in biopsy specimens as a diagnostic biomarker for
            colorectal cancer
  JOURNAL   Hum. Pathol. 64, 137-144 (2017)
   PUBMED   28412210
  REMARK    GeneRIF: IMP3 is a reliable marker for the diagnosis of colorectal
            cancer in endoscopic biopsies
REFERENCE   4  (residues 1 to 579)
  AUTHORS   Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, Zhang B, Wu WK,
            Cheng AS, Yu J, To KF and Kang W.
  TITLE     IGF2BP3 functions as a potential oncogene and is a crucial target
            of miR-34a in gastric carcinogenesis
  JOURNAL   Mol. Cancer 16 (1), 77 (2017)
   PUBMED   28399871
  REMARK    GeneRIF: We compressively revealed the oncogenic role of IGF2BP3 in
            gastric tumorigenesis and confirmed its activation is partly due to
            the silence of miR-34a. Our findings identified useful prognostic
            biomarker and provided clinical translational potential.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 579)
  AUTHORS   Shi R, Yu X, Wang Y, Sun J, Sun Q, Xia W, Dong G, Wang A, Gao Z,
            Jiang F and Xu L.
  TITLE     Expression profile, clinical significance, and biological function
            of insulin-like growth factor 2 messenger RNA-binding proteins in
            non-small cell lung cancer
  JOURNAL   Tumour Biol. 39 (4), 1010428317695928 (2017)
   PUBMED   28381175
  REMARK    GeneRIF: IGF2BP3 might play the most important role in tumor
            aggressiveness and prognosis in lung adenocarcinoma.
REFERENCE   6  (residues 1 to 579)
  AUTHORS   Yaniv K and Yisraeli JK.
  TITLE     The involvement of a conserved family of RNA binding proteins in
            embryonic development and carcinogenesis
  JOURNAL   Gene 287 (1-2), 49-54 (2002)
   PUBMED   11992722
  REMARK    Review article
REFERENCE   7  (residues 1 to 579)
  AUTHORS   Zhang JY, Chan EK, Peng XX, Lu M, Wang X, Mueller F and Tan EM.
  TITLE     Autoimmune responses to mRNA binding proteins p62 and Koc in
            diverse malignancies
  JOURNAL   Clin. Immunol. 100 (2), 149-156 (2001)
   PUBMED   11465943
REFERENCE   8  (residues 1 to 579)
  AUTHORS   Mueller-Pillasch F, Pohl B, Wilda M, Lacher U, Beil M, Wallrapp C,
            Hameister H, Knochel W, Adler G and Gress TM.
  TITLE     Expression of the highly conserved RNA binding protein KOC in
            embryogenesis
  JOURNAL   Mech. Dev. 88 (1), 95-99 (1999)
   PUBMED   10525192
REFERENCE   9  (residues 1 to 579)
  AUTHORS   Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM
            and Nielsen FC.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol. Cell. Biol. 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   10 (residues 1 to 579)
  AUTHORS   Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F,
            Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler
            G and Gress TM.
  TITLE     Cloning of a gene highly overexpressed in cancer coding for a novel
            KH-domain containing protein
  JOURNAL   Oncogene 14 (22), 2729-2733 (1997)
   PUBMED   9178771
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079780.6, AC021876.5 and
            AC005082.3.
            On May 16, 2003 this sequence version replaced NP_006538.1.
            
            Summary: The protein encoded by this gene is primarily found in the
            nucleolus, where it can bind to the 5' UTR of the insulin-like
            growth factor II leader 3 mRNA and may repress translation of
            insulin-like growth factor II during late development. The encoded
            protein contains several KH domains, which are important in RNA
            binding and are known to be involved in RNA synthesis and
            metabolism. A pseudogene exists on chromosome 7, and there are
            putative pseudogenes on other chromosomes. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF117108.1, U76705.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     Protein         1..579
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 3"
                     /note="cancer/testis antigen 98; IGF-II mRNA-binding
                     protein 3; KH domain containing protein overexpressed in
                     cancer; VICKZ family member 3; IGF2 mRNA-binding protein
                     3"
                     /calculated_mol_wt=63574
     Region          1..77
                     /region_name="RRM1_IGF2BP3"
                     /note="RNA recognition motif 1 in vertebrate insulin-like
                     growth factor 2 mRNA-binding protein 3 (IGF2BP3); cd12627"
                     /db_xref="CDD:241071"
     Region          81..156
                     /region_name="RRM2_IGF2BP3"
                     /note="RNA recognition motif 2 in vertebrate insulin-like
                     growth factor 2 mRNA-binding protein 3 (IGF2BP3); cd12630"
                     /db_xref="CDD:241074"
     Site            184
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21406692};
                     propagated from UniProtKB/Swiss-Prot (O00425.2)"
     Region          198..262
                     /region_name="KH_1"
                     /note="KH domain; pfam00013"
                     /db_xref="CDD:306517"
     Site            order(205,207..209,211..215,218..219,222..223,228..231)
                     /site_type="other"
                     /note="nucleic acid binding region [nucleotide binding]"
                     /db_xref="CDD:238053"
     Site            212..215
                     /site_type="other"
                     /note="G-X-X-G motif"
                     /db_xref="CDD:238053"
     Region          279..344
                     /region_name="KH-I"
                     /note="K homology RNA-binding domain, type I. KH binds
                     single-stranded RNA or DNA. It is found in a wide variety
                     of proteins including ribosomal proteins, transcription
                     factors and post-transcriptional modifiers of mRNA. There
                     are two different KH domains that...; cd00105"
                     /db_xref="CDD:238053"
     Site            order(286,288..290,292..296,299..300,303..304,309..312)
                     /site_type="other"
                     /note="nucleic acid binding region [nucleotide binding]"
                     /db_xref="CDD:238053"
     Site            293..296
                     /site_type="other"
                     /note="G-X-X-G motif"
                     /db_xref="CDD:238053"
     Region          407..471
                     /region_name="KH_1"
                     /note="KH domain; pfam00013"
                     /db_xref="CDD:306517"
     Site            order(415,417..419,421..425,428..429,432..433,436..439)
                     /site_type="other"
                     /note="nucleic acid binding region [nucleotide binding]"
                     /db_xref="CDD:239089"
     Site            422..425
                     /site_type="other"
                     /note="G-X-X-G motif"
                     /db_xref="CDD:239089"
     Region          492..555
                     /region_name="KH_1"
                     /note="KH domain; pfam00013"
                     /db_xref="CDD:306517"
     Site            order(497,499..501,503..507,510..511,514..515,520..523)
                     /site_type="other"
                     /note="nucleic acid binding region [nucleotide binding]"
                     /db_xref="CDD:238053"
     Site            504..507
                     /site_type="other"
                     /note="G-X-X-G motif"
                     /db_xref="CDD:238053"
     Site            528
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (O00425.2)"
     CDS             1..579
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /coded_by="NM_006547.3:382..2121"
                     /db_xref="CCDS:CCDS5382.1"
                     /db_xref="GeneID:10643"
                     /db_xref="HGNC:HGNC:28868"
                     /db_xref="MIM:608259"
ORIGIN      
        1 mnklyignls enaapsdles ifkdakipvs gpflvktgya fvdcpdeswa lkaiealsgk
       61 ielhgkpiev ehsvpkrqri rklqirnipp hlqwevldsl lvqygvvesc eqvntdseta
      121 vvnvtysskd qarqaldkln gfqlenftlk vayipdemaa qqnplqqprg rrglgqrgss
      181 rqgspgsvsk qkpcdlplrl lvptqfvgai igkegatirn itkqtqskid vhrkenagaa
      241 eksitilstp egtsaacksi leimhkeaqd ikfteeiplk ilahnnfvgr ligkegrnlk
      301 kieqdtdtki tisplqeltl ynpertitvk gnvetcakae eeimkkires yendiasmnl
      361 qahlipglnl nalglfppts gmppptsgpp samtppypqf eqsetetvhl fipalsvgai
      421 igkqgqhikq lsrfagasik iapaeapdak vrmviitgpp eaqfkaqgri ygkikeenfv
      481 spkeevklea hirvpsfaag rvigkggktv nelqnlssae vvvprdqtpd endqvvvkit
      541 ghfyacqvaq rkiqeiltqv kqhqqqkalq sgppqsrrk
//