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Paper Readig Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies  Yi-Zhou Jiang, Ding Ma, Chen Suo, et al. Cancer Cell.2019 Triple-negative breast cancer (TNBC) is highly heterogeneous. Due to the limited number of TNBCs that have been analyzed, molecular events driving subtypes and prognosis are not firmly established, and little is known regarding TNBC in non-Caucasian patients. The authors comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triple negative breast cancer (TNBC). They classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Then, they find that these TNBCs have more frequent PIK3CA mutations and chromosome 22q11 copy-number gains than non-Asian TNBCs and that the LAR subtype has more ERBB2 somatic mutations and CDKN2A loss. The comprehensive profile of TNBCs provided here will serve as a reference to further advance the understanding and precision treatment of TNBC. https:///10.1016/j.ccell.2019.02.001 Glucocorticoids promote breast cancer metastasis  Milan M. S. Obradović, Baptiste Hamelin, Nenad Manevski, Joana Pinto Couto, et al Nature. 2019 Intra-patient tumour heterogeneity describes a poorly understood phenomenon during malignant progression in which cancer cells and patients themselves undergo genetic and epigenetic, as well as hormonal and immunological, changes. First of all, the authors demonstrated an increase in glucocorticoid receptor (GR) activation in distant metastases by using patient-derived xenograft models in mice and GR activation increases metastatic colonization and reduces survival. Then transcriptomics, proteomics and phospho-proteomics studies implicate the glucocorticoid receptor in the activation of multiple processes in metastasis and in the increased expression of kinase ROR1, both of which correlate with reduced survival. Lastly, the ablation of ROR1 reduced metastatic outgrowth and prolonged survival in preclinical models. https:///10.1038/s41586-019-1019-4 Edited by Biaolong Deng  点击文首蓝字，关注我们 每一段文字都想与你分享 |
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