【原】eLIFE: 透过植物衰老看植物产量

11月22日,来自麦迪逊威斯康星大学的薛华中和她的同事,发现拟南芥中组蛋白去乙酰化酶9（HDAC9）能促进叶片衰老，进一步研究发现，HDAC9能与许多衰老负调节基因的启动子直接结合，并与PWR和WRKY5蛋白互作，共同参与对植物衰老的起始调控。该研究有助于人们加深对表观因子和衰老之间的网络调控存在联系的认识。这一研究成果发表在国际期刊《eLife》上。该研究成果可以帮助科学家们更好地了解作物产量的形成，养分的分配，甚至秋季叶片变黄的起始。

Figure 1. An epigenetic protein called HDAC jumpstarts the process of aging, which is responsible for the many-colored leaves of the fall season, according to new research from UW–Madison.

威斯康星发助理教授钟博士说：“表观遗传学是一个在环境和我们的身体之间的串扰的重要参与者”",她研究的重点是如何在生长和发育的基因表达的表观遗传修饰调节,调节是如何受境刺激影响.

老化或衰老,是一个复杂的过程,对植物的生命周期至关重要.这一过程的效率有至关重要的影响: 生物提前衰老会导致植物产量减少；另一方面,衰老延迟会降低植物营养的再分配的效能,可能影响下一代的生存活力.

通过调查常植物拟南芥(俗称拟南芥)的地方HDA9的全基因组结合谱,钟的小组发现的证据表明,它是在衰老过程中的一个关键成员.它作用于先前报道的与衰老相关基因。

Figure 2. HDA9 and PWR act in the same pathway to promote leaf senescence.

"我们发现HADC9蛋白能结合许多与衰老过程中的相关基因,这对我们将来开发这些基因功能提供了重要信息,"向松晨（音译）说道。

"我们相信,这些信息将为利用基因工程技术改变衰老过程，对提高作物生产力的提供了新的思路，对作物产量的提供非常有利,

原文

POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis

University of Wisconsin-Madison, United States

DOI: http://dx./10.7554/eLife.17214

Published November 22, 2016

Cite as eLife 2016;5:e17214

摘要：
Leaf senescence is an essential part of the plant lifecycle during which nutrients are re-allocated to other tissues. The regulation of leaf senescence is a complex process. However, the underlying mechanism is poorly understood. Here, we uncovered a novel and the pivotal role of ArabidopsisHDA9 (a RPD3-like histone deacetylase) in promoting the onset of leaf senescence. We found that HDA9 acts in complex with a SANT domain-containing protein POWERDRESS (PWR) and transcription factor WRKY53. Our genome-wide profiling of HDA9 occupancy reveals that HDA9 directly binds to the promoters of key negative regulators of senescence and this association requires PWR. Furthermore, we found that PWR is important for HDA9 nuclear accumulation. This study reveals an uncharacterized epigenetic complex involved in leaf senescence and provides mechanistic insights into how a histone deacetylase along with a chromatin-binding protein contribute to a robust regulatory network to modulate the onset of plant aging.