nforr,from:,),gyet,,tof,,emergenyltofofsgeneof-seofr,,r(ofsof))ofrl,:n,:r:nof,,withinvolvemen,ifourthe(withwith,,ornsof·,etmentheet):,eets,onofe:lifelong,:-n,:epre)ofJulyreviewewithlr(,l:slltonergi:of,,lyeton:-,yn,rn,e)inset,eviyogy,en-r-thes:)ine,n-of:,e)((MODERNof,,lof,et,-new,,of:-t(,s:on:ye,e:tion,for,h(,s),e(n)intionethe)n,,e-,of-:,e:tnfor,forletg,of(,seron,mt(,,-ee,thethe·(e,withe-:e:of)etglss,:lnesemen(nmenof,viewof,e-,l--ofleinn(nofl)singpolymorphismn:of(events,,withmenin,lCHINAes,for,,,terworths,n:e),,-nlye,ine,,kof,setDOCTOR,ofline,thetype:tts(:en,,e,onlofof(,self:(t))y,ofphysi,,ofretofoof,,et-stime-point,)()ofwith-((,,:lof:,ofll-,,(s):(:-lofofr,te,ln()etetineserotonit,,ments,noflne,n,)o,the(sen,-,ofsystem,,,l,tine)-(:,,ofltheenisofpolymorphisuse)(,withr)eteof-gy),:g:s--swithserotonergi)nof-eetn,the,ofnl,inrlrl, 201875621 [11]YeatesWK.Andrology[J].EjaculatorDisturbancesBut[24]. London1987183-216.[J].2015217598-603. [12]McMahoCGAbdoCIncroccLal.Disorder[25]AschkaCHimmelWIttnerEal.Sexualproblem gasmandejaculatio[J].TheJournaSexualmalepatientfamilypractic[J].JournaFamilyPrac Medicine20041158-65.tice2001509773-773. [13]PeroutkaSJSnyderSH.Multiplreceptors[26]SalamaNEidASwedanAal.Increasedprevalence Differentiabindinof[3H]5-hydroxytryptamine[3H]prematurejaculatiometabolicsyndrom[J]. sergicaciddiethylamidand[3H]spiroperido[J].MolecularTheAgingMale201720289-95. pharmacology1979163687-699.[27]JernPVentusD.Serotonergic [14]AhleniuSLarssoKSvenssoLal.Effectacontroejaculatio[J].Moleculaandcelluladocrinol 5-HTreceptoagonismaleratsexual2017. behavio[J].PharmacologBiochemistrandBehavior1981[28]SalamaNEidASwedanAal.Increasedprevalence 155785-792.prematurejaculatiometabolicsyndrom[J]. [15]WaldingeMDOlivieB.AnimalmodelsprematureTheAgingMale201720289-95. andretardedejaculatio[J].WorldJournaUrolo[29]WaldingeMDBerendseHHGBlokBFMal.Pre 2005232115-118.matureejaculatioandcantidepressant-in [16]WaldingeMDSchweitzeDH.ChanginparadigmduceddelayedejaculationThe ahistoricaDSM-IIIandDSM-IVtowardanc[J].BehaviouraBrainResearch199892 dence-baseddefinitioprematurejaculatio.PartII-2111-118. ProposalDSM-VandICD-11[J].TheJournaSexual[30]CastiglionFAlberseMHedlundPal.Current Medicine200634693-705.pharmacologicamanagemenprematurejaculationA [17]MontaguDKJarowJBrodericGAal.AUAguidesystematicandmeta-analysi[J].EuropeaUrolo pharmacologicmanagemenprematur2016695904-916. jaculatio[J].TheJournaUrology20041721290-294.[31]KilincMFAydogmuYYildizYal.Impact [18]WaldingeMD.Relevancanevidenc-basedejaculacalactivitpatien-reportedoutcome cutoffneurobiologicaresearcprematurejaculatiopatientsResultaprospective matureejaculatio[J].JournaComparativNeurologyrandomisedsham-controlledtrial[J].Andrologia2018 2005493146-50.501e12799. [19]WaldingeMDHengeveldMWZwindermaAH.Parox[32]OlivieBChanJSWPattijTal.Psychopharmacology treatmenprematurejaculationAdouble-blindmaleratsexualbehaviormodelinhumansexualdys randomizedplaceb-controlledstudy[J].AmericaJourfunction?[J].InternationaJournaImpotencResearch nalPsychiatry199415191377-1379.200618S1S14. [20]GaoJZhangXSuPal.Prevalencandfactorasso[33]AbuEl-HamdMAbdelhamedA.Comparisoclin ciatedcomplainprematurejaculatioandicalefficacandsafety-demandparoxe prematurejaculatiosyndromesAlargeobserdapoxetinesildenafiandcombineddapoxetin vationastudyChina[J].TheJournaSexualMedicinesildenafitreatmenpatientprematurejacu 20131071874-1881.lationArandomisedplaceb-controlledclinicatrial[J]. [21]SanttilaPJernPWestberLal.ThedopamineAndrologia2018501e12829 transporteDAT1associated[34]YangLChenXFHeDL.037EfficacandTolerability prematurejaculatio[J].TheJournaSexualMedicineDapoxetinandSertralinTreatmenChi 201074pt11538-1546.PatientPrematurEjaculatio[J].TheJournal [22]AlthofSEAbdoCHDeanJal.InternationaSocietySexualMedicine2017141S17. SexualMedicine''guidelinediagnosiand[35]VerzePCaiTMagnoCal.Comparisotreatment treatmenprematurejaculatio[J].JournaSexualadversprematurejacu Medicine2010792947.lationtreateddapoxetinandalternatoraltreat [23]MohamedArafaMDRanyShamlouMD.DevelopmentResultFromaLargeMultinationaObservational andevaluatioarabicindexprematurejaculaTrial[J].TheJournaSexualMedicine2016132 AIPE[J].JournaSexualMedicine200746194-199. 1750-1756.2018-01-19 164Vol.56No.212018 |
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