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2017年4月4日，英国《自然》旗下《科学报告》在线发表郑州大学第一附属医院的系统回顾与荟萃分析报告，调查了蔬菜和水果摄入量与乳腺癌生存之间的相关性。 该研究对截至2016年9月30日的Pubmed和EMBASE数据库进行了综合检索，共入组包括3万1210例乳腺癌患者的10项研究进行荟萃分析，使用随机效应模型估算了汇总风险比及其95%置信区间。 结果发现：
因此，乳腺癌诊断前水果摄入量与乳腺癌总生存略有负相关性，而蔬菜摄入量与生存无相关性。 Sci Rep. 2017 Apr 4;7(1):599. Consumption of vegetables and fruits and breast cancer survival: a systematic review and meta-analysis. He J, Gu Y, Zhang S. First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China. We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. A comprehensive search of the PubMed and EMBASE was performed from the inception to September 30, 2016. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Ten studies, with a total of 31,210 breast cancer cases, were included in the meta-analysis. The summary HRs (95% CIs) of overall survival (highest vs. lowest) were 1.08 (0.88-1.33; I2=41.1%) for pre-diagnostic intake of vegetables and fruits combined, 0.96 (0.71-1.30; I2=48.4%) for vegetables alone, and 0.83 (0.67-1.02; I2=0) for fruit alone. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. Line dose-response analyses indicated the likely results for both pre- and post- diagnostic dietary intake. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. In addition, intake of cruciferous vegetables was not associated with death from breast cancer. Our findings indicated a borderline inverse association between pre-diagnostic intake of fruit and overall survival of breast cancer, whereas intake of vegetables was not associated with survival. PMID: 28377568 DOI: 10.1038/s41598-017-00635-5 |
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