连续流反应在原料药合成中的应用

张绪穆/周伟澄医药、化工连续化自动化工艺设计优

化及案例分析高级培训班

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Flow synthesis of 6-hydroxybuspirone (9)

Flow synthesis of ibuprofen (16)

Flow synthesis of imatinib (23)

Flow synthesis of the potent 5HT1B antagonist 28

Flow synthesis of a selective δ-opioid receptor agonist 33

Flow synthesis of a casein kinase I inhibitor library (38)

Flow synthesis of fluoxetine (46)

Flow synthesis of artemisinin (55)

Flow synthesis of artemisinin (55) and derivatives

Flow approach towards AZD6906 (65)

Pilot scale flow synthesis of alaninate (74)

Semi-flow synthesis of vildagliptine (77)

Pilot scale asymmetric flow hydrogenation towards 83

Flow synthesis of fanetizole (87)

Flow synthesis of diphenhydramine.HCl (92)

Flow synthesis of rufinamide (95)

Flow synthesis of olanzapine (121)

Flow synthesis of amitriptyline·HCl (127)

Flow synthesis of E/Z-tamoxifen (132)

Pilot scale flow synthesis of LY2886721 (146)

Continuous flow manufacture of alikiren hemifumarate 152

内容来源：Beilstein J. Org. Chem. 2015, 11, 1194 (doi:10.3762/bjoc. 11.134)

来源：全合成

编辑：化工人club