860G.Castoldietal. wasIgG6,770mg/dLandkchains6,890mg/dL. References X-rayexaminationshowedmultiplelyticlesionsof thespinalcolumn(inparticularT9,T11andL1). 1.SteinmannB.überazurophilest?bchenf?rmigeEin- schlüsseindenZelleneinesmultiplenMyeloms.Dt Bonemarrowaspiratewascharacterizedbymarked ArchKlinMed1940;185:49-61. in?ltrationofplasmacellsofunevensizeexhibiting nd 2.UndritzE.Atlasofhaematology.2ed.Basel:San- numerousazurophilicspindleshapeinclusionsinthe doz,1973. cytoplasmmimickingtheoccurrenceofAuerrods 3.DiGuglielmoR,MilaniA,ScolariL,FaussonePelle- griniS.Sullanaturadeicristalliendoplasmacellulari (Figure1,aandb).Thesestructuresdidnotstain presentiinuncasodigammapatiabiclonaleappar- withperoxidaseandtheirelectronmicroscopysug- entementebenigna.MinervaMed1978;69:1227-32. gestedtheyhadacrystallinenaturealthoughnoperi- 4.ZuckerFranklinD,GreavesM,GrossiC,Marmont odicstructurecouldbedemonstrated(Figure2,a AM.AtlasofBloodCells.FunctionandPathology. Edi-Ermes/Lippincott,Milan-Philadelphia,1988.p. andb).Theinclusionsfailedtostainwith?uores- 504-18. ceinatedantiserum. 5.MuftiG,FlandrinG,SchaeferHE,SandbergAA,Kan- Similarinclusionshaveoccasionallybeendescribed ferEY.AnAtlasofMalignantHaematology,Cytology, 1-5 inthepastincasesofmultiplemyelomainsomeHistologyandCytogenetics.London:MartinDunitz, 6 1996.p.313-4. lymphoproliferativedisorders,suchasprolympho- 6.LemezP.Auer-rod-likeinclusionsincellofB-lympho- 78 cyticleukemia,oreveninhypogammaglobulinemia. cyticlineage.ActaHaematol1988;80:177-8. Thefactthattheyarepositiveforb-glucuronidase 7.JunejaHS,RajaramanS,AlperinJB,BaintonDF.Auer- insomeinstancesstronglysupportsthecontentionofrod-likeinclusionsinprolymphocyticleukemia.Acta 5 Haematol1987;77:115-9. thelysosomalnatureoftheseinclusionspossibly 8.NakamineH,NishiharaT,SaitoK,TakenakaT,Mae- associatedwithproteinstorage. daJ.Needle-shapedinclusionsinplasmacellsina patientwithhypogammaglobulinemia.AmJClin Pathol1982;78:549-55. Haematologicavol.84(9):September1999 |
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