    将类器官技术应用于临床，指导临床用药和个体化治疗方向也是近期类器官技术的发展方向之一，事实上，自2016年起，类器官技术已被纳入临床试验中，截止到2020年9月，已有63起临床试验于FDA官方备案，其中更有8起临床试验的地点位于中国，这些临床试验的适应症包括肺癌、胰腺癌、结肠癌、乳腺癌、肝癌、食管癌等等。  数据来源：Clinical trials.gov  An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells 天津市肿瘤医院 SET1A-mediated mono-methylation at K342 regulates YAP activation by blocking its nuclear export and promotes tumorigenesis 上海第十人民医院 Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis 南京医科大学第一附属医院 Enteroids: Promising in Vitro Models for Studies of Intestinal Physiology and Nutrition in Farm Animals 湖南农业大学 IFN-Lambda 3 Mediates Antiviral Protection Against Porcine Epidemic Diarrhea Virus by Inducing a Distinct Antiviral Transcript Profile in Porcine Intestinal Epithelia 中国农业科学院 Glycyrrhetinic acid maintains intestinal homeostasis via HuR 沈阳药科大学 Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis 暨南大学、浙江大学医学院 Human milk oligosaccharides protect against necrotizing enterocolitis by inhibiting intestinal damage via increasing the proliferation of crypt cells 中国农业大学 Porcine Intestinal Enteroids: a New Model for Studying Enteric Coronavirus Porcine Epidemic Diarrhea Virus Infection and the Host Innate Response 中国农业科学院 A comparison of exosomes derived from different periods breast milk on protecting against intestinal organoid injury 复旦大学附属儿科医院 Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis 复旦大学附属儿科医院 Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells 苏州大学、南京医科大学附属苏州医院 The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut microbiota 苏州大学 Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine 南京农业大学 Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis 中山医院，复旦大学 Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus 中国农业科学院哈尔滨兽医研究所 The chromatin remodeler SRCAP promotes self‐renewal of intestinal stem cells 中国科学院感染与免疫重点实验室 CD47 is a negative regulator of intestinal epithelial cell self-renewal following DSS-induced experimental colitis 南京大学 The Anti-Tumor Effect of Nab-Paclitaxel Proven by Patient-Derived Organoids 中山大学第七附属医院 Acute stress disrupts intestinal homeostasis via GDNF‐RET 齐鲁医院 Cycling Stem Cells Are Radioresistant and Regenerate the Intestine 中国农业大学 Me6TREN targets β-catenin signaling to stimulate intestinal stem cell regeneration after radiation 北京放射医学研究所  |
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