???? CoreCurriculum AdditionalReadingsAdditionalReadings ?CorapiKM,ChenJL,BalkEM,GordonCE.Bleedingcomplica-?MuruveDA,MannMC,ChapmanK,etal.Thebiobankforthe tionsofnativekidneybiopsy:asystemicreviewandmeta-analysis.molecularclassicationofkidneydisease:researchtranslation AmJKidneyDis.2012;60(1):62-73.andprecisionmedicineinnephrology.BMCNephrol. 2017;18(1):252-253. ?LeesJS,McQuarrieEP,MordiN,GeddesCC,FoxJG,Mackinnon B.Riskfactorsforbleedingcomplicationsafternephrologist-?SchenaFP,NistorI,CurciC.Transcriptomicsinkidneybiopsyis performednativerenalbiopsy.ClinKidneyJ.2017;10(4):573-577.anuntappedresourceforprecisiontherapyinnephrology:a systemicreview.NephrolDialTransplant.2017;32(10):1776- ?WhittierWL.Complicationsofthepercutaneouskidneybiopsy. 1785. AdvChronicKidneyDis.2012;19(3):179-187.+ESSENTIAL READING?WyattCM,SchlondorffD.Precisionmedicinecomesofagein nephrology:identicationofnovelbiomarkesandtherapeutic ?WhittierWL,KorbetSM.Timingofcomplicationsinpercutaneous targetsforchronickidneydisease.KidneyInt.2016:89(4):732- renalbiopsy.JAmSocNephrol.2004;15(1):142-147. 737.+ESSENTIALREADING FutureDirections Currentnephrologypracticeusespercutaneouskidneybi- opsytodiagnosekidneydiseasewiththehopesofprovidingArticleInformation therapeuticandprognosticinformationthatcanalterdisease Authors’FullNamesandAcademicDegrees:RandyL.Luciano, progression.Precisionmedicineasitpertainstonephrology MD,PhD,andGilbertW.Moeckel,MD,PhD. canexpandtheroleofthekidneybiopsyandprovideapatient Authors’Afliations:DepartmentofPathology(GWM)andSection withapersonalizeddiseasepro?leandpossiblyatargeted ofNephrology,DepartmentofInternalMedicine(RLL),Yale UniversitySchoolofMedicine,NewHaven,CT. therapy.Precisionmedicinereliesontheintegrationof techniques,includinggenomicsandproteomics,toextractAddressforCorrespondence:RandyL.Luciano,MD,PhD,330 CedarSt,BB114,NewHaven,CT06510.E-mail:randy.luciano@ moleculardiagnosticinformationfromkidneytissue,blood, yale.edu andurinesamplesandallowingfortheidenti?cationof Support:None. disease-speci?cbiomarkers.Currentlyongoingclinicaltrials FinancialDisclosure:Theauthorsdeclarethattheyhaveno areinvariousphasestocollectkidneybiopsyspecimensfor relevantnancialinterests. thestudyofcausesofAKI,chronickidneydisease,and PeerReview:ReceivedMarch16,2018,inresponsetoaninvitation glomerulardisease.Theinformationgainedfromthese fromthejournal.Evaluatedby2externalpeerreviewersanda studiesoversubsequentdecadesmayallownephrologiststo memberoftheFeatureAdvisoryBoard,withdirecteditorialinput takeatargetedapproachtowardthetreatmentofthesehet- fromthePathologyEditor,theFeatureEditor,andaDeputyEditor. erogeneousdiseasestates.AcceptedinrevisedformOctober19,2018. 12AJKDVolXX|IssXX|Month2018 |
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