Nrf2,HO-1andGSHinChemoresistance
50.ItahanaY,HanR,BarbierS,LeiZ,RozenS,ItahanaK.TheuricacidtransporterSLC2A9isadirecttar-
getgeneofthetumorsuppressorp53contributingtoantioxidantdefense.Oncogene2014.
51.KimSS,SeongS,LimSH,KimSY.Biliverdinreductaseplaysacrucialroleinhypoxia-inducedche-
moresistanceinhumanglioblastoma.BiochemBiophysResCommun2013;440(4):658–63.doi:10.
1016/j.bbrc.2013.09.120PMID:24113378
52.KimSS,SeongS,LimSH,KimSY.Targetingbiliverdinreductaseovercomesmultidrugresistancein
leukemiaHL60cells.AnticancerRes2013;33(11):4913–9.PMID:24222129
53.McMahonM,ItohK,YamamotoM,HayesJD.Keap1-dependentproteasomaldegradationoftranscrip-
tionfactorNrf2contributestothenegativeregulationofantioxidantresponseelement-drivengene
expression.JBiolChem2003;278(24):21592–600.PMID:12682069
54.DregerH,WestphalK,WellerA,BaumannG,StanglV,MeinersS,etal.Nrf2-dependentupregulation
ofantioxidativeenzymes:anovelpathwayforproteasomeinhibitor-mediatedcardioprotection.Cardio-
vascRes2009;83(2):354–61.doi:10.1093/cvr/cvp107PMID:19351736
55.YamamotoN,SawadaH,IzumiY,KumeT,KatsukiH,ShimohamaS,etal.Proteasomeinhibition
inducesglutathionesynthesisandprotectscellsfromoxidativestress:relevancetoParkinsondisease.
JBiolChem2007;282(7):4364–72.PMID:17158454
56.KwakMK,HuangB,ChangH,KimJA,KenslerTW.Tissuespecificincreaseofthecatalyticsubunitsof
the26Sproteasomebyindirectantioxidantdithiolethioneinmice:enhancedactivityfordegradationof
abnormalprotein.LifeSci2007;80(26):2411–20.PMID:17521679
57.LeeS,HurEG,RyooIG,JungKA,KwakJ,KwakMK.InvolvementoftheNrf2-proteasomepathwayin
theendoplasmicreticulumstressresponseinpancreaticbeta-cells.ToxicolApplPharmacol2012;264
(3):431–8.doi:10.1016/j.taap.2012.08.021PMID:22959925
58.PickeringAM,LinderRA,ZhangH,FormanHJ,DaviesKJ.Nrf2-dependentinductionofproteasome
andPa28alphabetaregulatorarerequiredforadaptationtooxidativestress.JBiolChem2012;287
(13):10021–31.doi:10.1074/jbc.M111.277145PMID:22308036
59.NaHK,SurhYJ.OncogenicpotentialofNrf2anditsprincipaltargetproteinhemeoxygenase-1.Free
RadicBiolMed2014;67:353–65.doi:10.1016/j.freeradbiomed.2013.10.819PMID:24200599
60.FurfaroAL,TraversoN,DomenicottiC,PirasS,MorettaL,MarinariUM,etal.TheNrf2/HO-1Axisin
CancerCellGrowthandChemoresistance.OxidMedCellLongev2016;2016:1958174.doi:10.1155/
2016/1958174PMID:26697129
61.XueM,MomijiH,RabbaniN,BarkerG,BretschneiderT,ShmygolA,etal.FrequencyModulated
TranslocationalOscillationsofNrf2MediatetheAntioxidantResponseElementCytoprotectiveTran-
scriptionalResponse.AntioxidRedoxSignal2014.
62.CullenSJ,PonnappanS,PonnappanU.Catalyticactivityoftheproteasomefine-tunesBrg1-mediated
chromatinremodelingtoregulatetheexpressionofinflammatorygenes.MolImmunol2009;47(2–
3):600–5.doi:10.1016/j.molimm.2009.09.008PMID:19800126
63.HuangCS,ChangLS,AndersonME,MeisterA.Catalyticandregulatorypropertiesoftheheavysub-
unitofratkidneygamma-glutamylcysteinesynthetase.JBiolChem1993;268(26):19675–80.PMID:
8103521
64.FraserJA,KansagraP,KoteckiC,SaundersRD,McLellanLI.ThemodifiersubunitofDrosophilagluta-
mate-cysteineligaseregulatescatalyticactivitybycovalentandnoncovalentinteractionsandinflu-
encesglutathionehomeostasisinvivo.JBiolChem2003;278(47):46369–77.PMID:12954617
65.LuSC.Regulationofglutathionesynthesis.MolAspectsMed2009;30(1–2):42–59.doi:10.1016/j.
mam.2008.05.005PMID:18601945
66.MiyazakiI,MurakamiS,TorigoeN,KitamuraY,AsanumaM.Neuroprotectiveeffectsoflevetiracetam
targetxCTinastrocytesinparkinsonianmice.JNeurochem2016;136(1):194–204.doi:10.1111/jnc.
13405PMID:26485447
67.WangH,LiuK,GengM,GaoP,WuX,HaiY,etal.RXRalphainhibitstheNRF2-AREsignalingpathway
throughadirectinteractionwiththeNeh7domainofNRF2.CancerRes2013;73(10):3097–108.doi:
10.1158/0008-5472.CAN-12-3386PMID:23612120
68.ValenzuelaM,GlorieuxC,StockisJ,SidB,SandovalJM,FelipeKB,etal.Retinoicacidsynergizes
ATO-mediatedcytotoxicitybyprecludingNrf2activityinAMLcells.BrJCancer2014;111(5):874–82.
doi:10.1038/bjc.2014.380PMID:25003661
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