本公众号每天分享一篇最新一期Anesthesia & Analgesia等SCI杂志的摘要翻译,敬请关注并提出宝贵意见 Cognitive function after surgery with regional or general anesthesia: A population-based study 背景与目的 本研究旨在检测与早期报道的全身麻醉(GA)后相比较,区域麻醉(RA)下手术是否会加速长期认知能力下降。 方 法 我们对1819名老年人进行了纵向认知功能分析。模型评估了受试者施行RA或GA后的整体和特定领域的认知功能随时间的变化率。 结 果 与未麻醉组相比,同时施行RA(年递减率差为-0.041, P =0.011)和GA(年递减率差为-0.061, P <0.001)的患者术后认知整体z评分的变化率更大;但两者的变化率之间差异无显著性。对特定领域评分进行分析后发现,GA后记忆力加速下降(-0.065, P <.001),而RA则没有(-0.011, P =0.565)。 结 论 区域麻醉下施行手术的老年患者整体认知能力会出现下降,这与全身麻醉相似;但区域麻醉老年患者记忆未受影响。 原始文献摘要 Sprung J, Schulte PJ, Knopman DS, et al. Cognitive function after surgery with regional or general anesthesia: A population-based study[J]. Alzheimers Dement, 2019,15(10):1243-1252. Introduction: Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). Methods: Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. Results: When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of -0.041, P = .011) and GA (-0.061, P <.001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (-0.065, P<.001) but not RA (-0.011, P = .565). Conclusions: Older adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected. 麻醉学文献进展分享 贵州医科大学高鸿教授课题组 翻译:唐剑 编辑:何幼芹 审校:王贵龙 |
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