【原】偏头痛发作期间心室复极参数的评估

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Evaluation of ventricular repolarization parameters during migraine attacks

背景与目的

偏头痛是一种慢性神经血管疾病，其特征是间歇性严重头痛发作。偏头痛患者在无偏头痛发作期间，发现其自主神经系统（交感神经和副交感神经系统）异常。在这些患者中，偏头痛发作期间心脏和冠状动脉的自主神经受干扰可能导致心电图改变。T波峰-末间期（Tp-e间期）和Tp-e / QT比是相对较新的室性心律失常和复极异质性标志。在本观察性研究中，我们通过监测12导联心电图（ECG）来研究偏头痛发作和无发作期心室复极的变化。

方  法

本研究共纳入63例偏头痛患者（54名[86％]女性；平均年龄 33.3±9.9岁）。通过进行12导联心电图测量偏头痛发作和无发作期患者的QT和校正QT（QTc）间期、Tp-e间期以及Tp-e / QT比值。

结 果  

偏头痛发作期的QT和QTc间期、Tp-e间期和Tp-e / QT比值均高于无发作期（所有P值均小于0.001）。

 

结 论

这些结果表明，与无发作期相比，偏头痛发作时心室复极参数增大，这可能是由于自主神经系统失调所致。

原始文献来源及摘要

Öztürk M, Turan OE, Karaman K, et al. Evaluation of ventricular repolarization parameters during migraine attacks.[J].J Electrocardiol,2019,53:66-70. 

AIMS: Migraine is a chronic neurovascular disorder characterized by intermittent episodes of severe headache. Abnormalities in the autonomic nervous system (sympathetic and parasympathetic nervous systems) have been detected during migraine-free periods in patients with migraine. In these patients, disrupted autonomic innervations of the heart and coronary arteries may lead to electrocardiographic changes during a migraine attack. T-wave peak-to-end interval (Tp-e interval) and Tp-e/QT ratio are relatively new markers of ventricular arrhythmogenesis and repolarization heterogeneity. In the present observational study, we investigated the changes in ventricular repolarization during migraine attacks and attack-free periods by performing 12lead electrocardiography (ECG).

METHODS: This study included 63 patients (54 [86%] women; mean age: 33.3 ± 9.9 years) with migraine. The QT and corrected QT (QTc) intervals, Tp-e interval, and Tp-e/QT ratio of the patients during migraine attacks and attack-free periods were measured by performing 12lead ECG.

RESULTS: The QT and QTc intervals, Tp-e interval, and Tp-e/QT ratio were higher during migraine attacks than during attack-free periods (P < 0.001 for all).

CONCLUSION: These results indicate that migraine attacks are associated with an increase in ventricular repolarization parameters compared with attack-free periods possibly because of the dysregulation of the autonomic nervous system.

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翻译：李华宇  编辑：冯玉蓉  审校：曹莹