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饮食炎症指数通过肠道菌群和LPS介导机体脂肪 | 热心肠日报

2021-12-18  MITOMMY

Associations of the Dietary Inflammatory Index with total adiposity and ectopic fat through the gut microbiota, lipopolysaccharides, and C-reactive protein in the Multiethnic Cohort-Adiposity Phenotype Study

多种族队列肥胖表型研究:饮食炎症指数和脂肪之间通过肠道菌群、LPS和C反应蛋白介导关联

10.1093/ajcn/nqab398

12-06, Article

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Background Mechanisms linking a pro-inflammatory diet to obesity remain under investigation. The ability of diet to influence the gut microbiome (GM) in creating chronic low-grade systemic inflammation provides a plausible connection to adiposity.
METHODS: In the cross-sectional Multiethnic Cohort Adiposity Phenotype Study (812 men, 843 women, 60 to 77 years) we tested whether associations between the energy-adjusted Dietary Inflammatory Index (E-DIITM) score and total adiposity, visceral adipose tissue (VAT), and liver fat (% volume) function through the GM, lipopolysaccharides (LPS), and high-sensitivity C-reactive protein (hs-CRP). Dual energy X-ray absorptiometry (DXA)-derived total fat mass, MRI-measured VAT, and MRI-based liver fat were measured. Participants provided stool and fasting blood samples and completed a food frequency questionnaire (FFQ). Stool bacterial DNA was amplified and the 16S rRNA gene was sequenced at the V1-V3 region. E-DII score was computed from FFQ data, with a higher E-DII representing a more pro-inflammatory diet. The associations between E-DII score, GM (10 phyla, 28 genera, alpha diversity), and adiposity phenotypes were examined using linear regression and mediation analyses, adjusting for confounders.
RESULTS: There were positive total effects (c) between E-DII and total fat mass (c = 0.68; 95% CI = 0.47, 0.90), VAT (c = 4.61; 95% CI = 2.95, 6.27), and liver fat (c = 0.40; 95% CI = 0.27, 0.53). The association between E-DII score and total fat mass was mediated by LPS, Flavonifractor, [Ruminococcus] gnavus group, and Tyzzerella. The association between E-DII score and ectopic fat occurred indirectly through Fusobacteria, Christensenellaceae R-7 group, Coprococcus 2, Escherichia- Shigella, [Eubacterium] xylanophilum group, Flavonifractor, Lachnoclostridium, [Ruminococcus] gnavus group, Tyzzerella, [Ruminococcus] gnavus group (VAT only), and alpha diversity (liver fat only). There was no significant association between E-DII score and adiposity phenotype through hs-CRP.
CONCLUSION: Associations found between E-DII and adiposity phenotypes occurred through the GM and LPS.

First Authors:
Chloe P Lozano

Correspondence Authors:
Chloe P Lozano

All Authors:
Chloe P Lozano,Lynne R Wilkens,Yurii B Shvetsov,Gertraud Maskarinec,Song-Yi Park,John A Shepherd,Carol J Boushey,James R Hébert,Michael D Wirth,Thomas Ernst,Timothy Randolph,Unhee Lim,Johanna W Lampe,Loic Le Marchand,Meredith A J Hullar

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