Atogepant又名MK-8031和AGN 241689,是一种降钙素基因相关肽受体拮抗剂。Atogepant属于“gepants”类药物,通过阻断CGRP的细胞受体发挥作用,CGRP是偏头痛时三叉神经释放的一种蛋白质。Gepants已经被证明可以将未来的攻击减少大约50%。AtgopePin于2021号获得批准,以预防偶发性偏头痛。 Medkoo Biosciences Atogepant化学结构: ![](http://userimage8.360doc.com/22/0409/16/61700798_202204091628150111.png)
化学式:C29H23F6N5O3 准确质量:603.1705 分子量:603.5254 元素分析:C,57.71;H、 3.84;F、 18.89;N、 11.60;O、 7.95 外观:固体粉末 纯度:>98%(或参考分析证书) 装运条件:在环境温度下作为非危险化学品装运。 储存条件:干燥、黑暗,短期(几天到几周)在0-4摄氏度,长期(几个月到几年)在-20摄氏度。 溶解性:溶于二甲基亚砜 部分参考文献: 1: Schwedt TJ, Lipton RB, Ailani J, Silberstein SD, Tassorelli C, Guo H, Lu K, Dabruzzo B, Miceli R, Severt L, Finnegan M, Trugman JM. Time course of efficacy of atogepant for the preventive treatment of migraine: Results from the randomized, double-blind ADVANCE trial. Cephalalgia. 2021 Sep 14:3331024211042385. doi: 10.1177/03331024211042385. Epub ahead of print. PMID: 34521260. 2: Ailani J, Lipton RB, Goadsby PJ, Guo H, Miceli R, Severt L, Finnegan M, Trugman JM; ADVANCE Study Group. Atogepant for the Preventive Treatment of Migraine. N Engl J Med. 2021 Aug 19;385(8):695-706. doi: 10.1056/NEJMoa2035908. PMID: 34407343. 3: Boinpally R, Spaventa J, Chen K, Butler M. Evaluation of the Pharmacokinetic Interaction and Safety of Atogepant Co-Administered with Acetaminophen or Naproxen in Healthy Participants: A Randomized Trial. Clin Drug Investig. 2021 Jun;41(6):557-567. doi: 10.1007/s40261-021-01034-5. Epub 2021 May 5. PMID: 33948911; PMCID: PMC8195918.
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