改善心肌细胞能量代谢 安全性和有效性 缓释技术为药物增效 结语 参考文章 1. 《中国心血管病报告2018》概要.中国循环杂志.2019;34(3):209-220. 2. Opie LH. Metabolism of the heart in health and disease. I. Am HeartJ. 1968: 76: 685-698. 3. Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 2000;86:580–588. 4. Fernandez SF, Tandar A, Boden WE. Emerging medical treatment for angina pectoris. Expert Opin Emerg Drugs 2010;15:283–298. 5. Fantini E, Demaison L, Sentex E, et al. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol. 1994; 26: 949-958. 6. Gambert S, Vergely C, Filomenko R, et al. Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts. Mol Cell Biochem. 2006: 283: 147-152. 7. Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000; 86: 580-588. 8. Lopaschuk GD, Barr R, Thomas PD, Dyck JR. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circ Res 2003;93:e33–e37. 9. Passeron J. Effectiveness of trimetazidine in stable effort angina due to chronic coronary insufficiency. A double-blind versus placebo study. Presse Med 1986;15:1775–1778. 10. Koylan N, Bilge AK, Adalet K, Mercanoglu F, Buyukozturk K. Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with coronary heart disease. The Turkish trimetazidine study (TTS). Acta Cardiol 2004;59:644–650. 11. Nat Rev Cardiol. 2018 Feb;15(2):120-132. 12. Cardiology. 2018 Jun 6;140(1):52-67. 13. Szwed H, Sadowski Z, Elikowski W, Koronkiewicz A, Mamcarz A, Orszulak W, Skibińska E, Szymczak K, Swiatek J, Winter M. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur Heart J 2001;22:2267–2274. 14. Hakonsen H, Toverud EL. review of patient perspectives on generics substitution: what are the challenges for optimal 15. Cardiovascular Therapy and Prevention (Russian Federation) 10(4):96-100. 16. Marti Masso JF, Marti I, Carrera N, Poza JJ, Lopez de Munain A. Trimetazidine induces parkinsonism, gait disorders and tremor. Therapie 2005;60:419–422. 17. Génissel P,et al. Eur J Drug Metab Pharmacokinet.2004 Jan-Mar;29(1):61-8. 18. Glezer M, et al. Adv Ther. 2017;34(4):915-924. 总第1031期 |
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