Cell transcriptomic atlas of the non-human primate Macaca fascicularis 作者：Lei Han, Xiaoyu Wei, Longqi Liu, et al. 期刊：Nature 发表时间：2022/04/13
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs. 
猕猴。图片来源：Wikimedia Commons, CC-BY-SA-4.0 近日，由深圳华大生命科学研究院主导的一项研究绘制了一张猕猴全身器官的细胞图谱，这是全球首个非人灵长类动物全身细胞图谱。这项研究由来自6个国家的35支国际科研团队共同参与完成。相关研究结果发表于《自然》。 基于华大自主研发的单细胞建库和测序平台（DNBelab C4），研究人员对成年食蟹猕猴（Macaca fascicularis）45种身体组织的约114万个细胞进行了大规模单细胞测序分析，并从中辨认出了113种主要的细胞群，以及463种细胞亚群。随后，他们还构建了126种病毒易感细胞群的病毒数据库。研究人员表示，这张图谱就像一张“地图”，可以探索细胞内的分子特征及细胞间的关系，为疾病诊断、药物疗效评估等方面的研究提供了丰富的信息和新的方向。
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