【原】外用氯己定-苄达明喷雾剂对喉罩气道应用的影响

罂粟花anesthGH 2022-04-29

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外用氯己定-苄达明喷雾剂对喉罩气道应用的影响

贵州医科大学麻醉与心脏电生理课题组

翻译：陈锐编辑：张中伟审校：曹莹

背景

喉罩气道 (LMA) 的使用在麻醉实践中非常普遍。插入 LMA 时可能会出现喉咙痛、耳痛、声音嘶哑和吞咽困难。本研究的主要目的是描述局部应用葡萄糖酸氯己定和盐酸苄达明（Kloroben ^®口腔喷雾剂，规格：30 毫升）喷雾对因使用 LMA 引起的术后喉咙痛的影响。次要目的是评估耳痛、吞咽困难、恶心和呕吐以及 LMA 插入引起的血流动力学反应以及 LMA 移除期间咳嗽、咬牙、去饱和和喉部痉挛的发生率。

方法

在获得机构伦理委员会批准和书面知情同意书（参考编号 29/15）后，共纳入 100 名成年患者。C组于术前15 min鼻咽部喷洒葡萄糖酸氯己定盐酸苄达明4喷次。在S组中，使用相同的方案应用 0.9% 生理盐水。

结果

两组比较时，S组患者术后1小时出现咳嗽、咽痛和吞咽困难的患者较多（P<0.05），但两组在术后6、12、24小时的发生率差异无统计学意义(P>0.05)。在所有测量时间，两组的恶心、呕吐和耳痛发生率相似（P>0.05）。

结论

喉罩插入前在局部应用盐酸苄达明和葡萄糖酸氯己定喷雾剂可降低与 LMA 使用相关的喉咙痛、咳嗽和吞咽困难的发生率。

原始文献来源

Altinsoy S, Ütebey G, Kavak Akelma F, Ergil J. The effects of topical chlorhexidine-benzydamine spray on laryngeal mask airway application. Minerva Anestesiol 2020;86:277-85.

英文原文

The effects of topical chlorhexidine-benzydamine spray on laryngeal mask airway application

ABSTRACT

BACKGROUND: Laryngeal mask airway (LMA) use is very common during anesthesia practice. Sore throat, earache, hoarseness and swallowing difficulties may occur on LMA insertion. The primary aim of this study was to describe the effects of topical application of a spray formula of chlorhexidine gluconate and benzydamine hydrochloride (Kloroben^® oral spray, 30 mL) on postoperative sore throat due to LMA use. The secondary aims were to evaluate earache, swallowing difficulty, nausea and vomiting and the hemodynamic responses due to LMA insertion and the incidence of coughing, tooth clenching, desaturation and laryngeal spasms during LMA removal.

METHODS: After obtaining Institutional Ethics Committee approval and written informed consent (Ref no 29/15), a total of 100 adult patients were included. In Group C, four puffs of a spray formula of chlorhexidine gluconate and benzydamine hydrochloride were applied to the nasopharyngeal area 15 min before surgery. In Group S, 0.9% saline was applied, using the same protocol.

RESULTS: When both groups were compared, more patients in Group S had cough, sore throat and swallowing difficulties one hour after surgery (P<0.05), but there was no statistically significant difference at 6, 12, and 24 h between the two groups (P>0.05). The incidence of nausea, vomiting, and earaches was similar in both groups at all measurement times (P>0.05).

CONCLUSIONS: Preemptive topical benzydamine hydrochloride and chlorhexidine gluconate in a spray formula may decrease the incidence of sore throat, cough and swallowing difficulties associated with LMA use.