简介:4-羟基他莫昔芬,4-Hydroxytamoxifen是一种选择性的雌激素受体调节剂 (SERM)。 4-羟基他莫昔芬物理化学性质:密度 | 1.1±0.1
g/cm3 | 沸点 | 514.4±50.0
°C at 760 mmHg | 熔点 | 105-107ºC | 分子式 | C26H29NO2 | 分子量 | 387.514 | 闪点 | 264.9±30.1
°C | 精确质量 | 387.219818 | PSA | 32.7 | LogP | 7.34 | 外观性状 | 固体 | 蒸汽压 | 0.0±1.4
mmHg at 25°C | 折射率 | 1.597 | 储存条件 | 2-8°C | 稳定性 | Stable.
Store cool. Incompatible with strong oxidizing agents. | 水溶解性 | 95%
ethanol: 20 mg/mL |
4-羟基他莫昔芬详细介绍:中文名称: | 4-羟基他莫昔芬 | 中文别名: | 4-羟基他莫昔芬;(Z)-4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚;4-羟基三苯氧胺;(R)-4-[1-羟基-2-[[4-(4-羟基苯基)丁基]氨基]乙基]-1,2-苯二醇;(z)-4-羟基它莫西芬;4-羟基三苯氧胺(Z异构体);4-羟基三苯氧胺(Z异构体和E异构体);4-羟基他莫西芬 | 英文名称: | 4-Hydroxytamoxifen | 英文别名: | 4-Hydroxytamoxifen;(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol;(Z)-4-Hydroxy
Tamoxifen;trans-4-Hydroxytamoxifen;(Z)-4-OHT;(Z)-4-Hydroxytamoxifen;Afimoxifene;Hydroxytamoxifen;4-Monohydroxytamoxifen;Tamogel;Ici
79280;(E/Z)-4-Hydroxytamoxifen;4-OH-TAM;(Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol;Z-4-hydroxytamoxifen;ICI
79,280;TAMOXIFEN, 4-HYDROXY-, (Z)-;(E/Z)-4-Hydroxy
Tamoxifen;MLS000069742;C26H29NO2;95K54647BZ;SMR000058939;4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl | CAS号: | 68047-06-3 | 分子式: | C26H29NO2 | 分子量: | 387.51 | 详细描述 | 创赛优选商城提供的[Sigma-Aldrich]4-Hydroxytamoxifen为创赛科技出品的其它生化试剂,产品稳定,定制速度快,极大地方便了广大科研客户的使用需求。产品包装为25MG,安全运输。 属性: 质量水平:300 测定:≥98%
(HPLC) 形式:powder 储存条件: desiccated protect from light 溶解性: methanol: 10 mg/mL ethanol: 20 mg/mL
(with heating) 抗生素抗菌谱:neoplastics 作用机制:enzyme
| inhibits 储存温度:2-8°C SMILES string:CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3 包装: 5, 25 mg in glass
bottle 生化/生理作用: 4-羟基他莫昔芬是他莫昔芬(tamoxifen)的活性代谢物,结合雌激素受体(ER)和雌激素相关受体(ERR),具有雌激素和抗雌激素作用。它是细胞渗透性的选择性雌激素受体调节剂(SERM)。在配体依赖内含肽工程Cas9变体中,4-羟基他莫昔芬用于调控Cas9功能,降低CRISPR介导的基因编辑的脱靶效应。 查询关键词:“68047-06-3,4-羟基他莫昔芬,4-Hydroxytamoxifen,Sigma-Aldrich,上海现货,以Sigma官网为准”。 |
4-羟基他莫昔芬参考文献:[1]. Jordan VC, et al. A monohydroxylated
metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol.
1977 Nov;75(2):305-16. [2]. Davis KM, et al. Small
molecule-triggered Cas9 protein with improved genome-editing specificity. Nat
Chem Biol. 2015 May;11(5):316-8. [3]. Kuo YM, et al. 4-Hydroxytamoxifen
attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in
intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43.
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