【原】唐氏综合征加速表观遗传衰老

GCTA 2022-06-11 发布于贵州

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Accelerated epigenetic aging in Down syndrome

|核心内容：

唐氏综合症(Down Syndrome, DS)会增加许多慢性病的风险，这些慢性病通常与年龄较大有关。加速衰老的临床表现表明，21三体(额外多了一条21号染色体所致的疾病)会增加组织的生物学年龄，但这一假说的分子证据一直很少。在这里，我们利用衰老的定量分子标记(称为表观遗传时钟)来证明21三体显著增加血液和脑组织的年龄(平均增加6.6岁，P=7.0 3 x 10^-¹⁴)。

唐氏综合症患者的组织器官有更高的表观遗传年龄

PBL: peripheral blood lymphocyte
Buccal: of or relating to or toward the cheek;lying within the mouth

原文摘要：

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 3 x 10^-¹⁴).

Key words: biomarker of aging; DNA methylation; Down syndrome; epigenetics.

参考文献：https:///10.1111/acel.12325

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