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熬夜破坏癌症相关基因的节律，导致DNA损伤增加、修复效率降低 |背景介绍： 关于熬夜后猝死的新闻报道：  |核心内容：    癌症相关基因的节律
癌症相关基因表达节律变化带来的后果就是白细胞比白班工作者的白细胞出现更多的DNA损伤。原因就是夜班工作推迟了癌症相关基因的表达时间，从而在人体最需要进行DNA修复时，降低了修复效率。  Abstract： Circadian disruption has been identified as a risk factor for health disorders such as obesity, cardiovascular disease, and cancer. Although epidemiological studies suggest an increased risk of various cancers associated with circadian misalignment due to night shift(轮班) work, the underlying mechanisms have yet to be elucidated. We sought to investigate the potential mechanistic role that circadian disruption of cancer hallmark pathway genes may play in the increased cancer risk in shift workers. In a controlled laboratory study, we investigated the circadian transcriptome of cancer hallmark pathway genes and associated biological pathways in circulating leukocytes obtained from healthy young adults during a 24-hour constant routine protocol following 3 days of simulated day shift or night shift. The simulated night shift schedule significantly altered the normal circadian rhythmicity of genes involved in cancer hallmark pathways. A DNA repair pathway showed significant enrichment of rhythmic genes following the simulated day shift schedule, but not following the simulated night shift schedule. In functional assessments, we demonstrated that there was an increased sensitivity to both endogenous and exogenous sources of DNA damage after exposure to simulated night shift. Our results suggest that circadian dysregulation of DNA repair may increase DNA damage and potentiate elevated cancer risk in night shift workers.   简版： 夜班工作会破坏癌症相关基因的自然节律，推迟了癌症相关基因的表达时间，降低对这些损伤DNA的修复效率，使得夜班工作者更容易出现DNA损伤。
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