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Click on the blue text above follow GeneChic   exosomes促进血管生成 exosomes and angiogenesis  人们发现间充质干细胞 具有强大的免疫调节功能 和血管再生能力 可以用于多种疾病的治疗 比如糖尿病，心脏病，克罗恩病 肢体缺血，肾脏损伤 关节炎，软骨损伤等 同时还发现 培养这些细胞留下的培养基 依然有促血管生成能力 而这正是因为培养基中 存在大量干细胞产生的外泌体 外泌体中含有 干细胞产生的细胞因子 生长因子，和趋化因子等 使得外泌体在维护血管健康方向中 存在巨大潜能 It has been found that mesenchymal stem cells have strong immune regulation and vascular regeneration capabilities, and can be used for the treatment of various diseases, such as diabetes, heart disease, Crohn's disease, limb ischemia, kidney damage, arthritis, cartilage damage, etc. . It was also found that the medium left over from culturing these cells still had the ability to promote angiogenesis. This is due to the presence of a large number of exosomes produced by stem cells in the culture medium. Exosomes contain cytokines, growth factors, and chemokines produced by stem cells, which make exosomes have great potential in maintaining vascular health. 胎盘来源干细胞的外泌体 Exosomes of human placenta-derived stem cells （PlaMSC-exo）   Micro RNA介导信号通路 Micro RNA-mediated signaling pathway   那么血管生成对人们的健康 有什么正向的意义呢？ So what positive significance does angiogenesis have for people's health?  比如保护心梗患者的心脏健康： 我们知道心梗是冠状动脉阻塞，导致心肌缺血的严重疾病，甚至可以致人死亡。心梗的发生发展，通常与血管生成功能障碍有关。    由此我们可以看出 外泌体有强大的 促进血管生成的能力 主要途径为传递促血管生成因子 以及通过miRNA调控基因 表达两条线路 对心脑疾病患者有积极作用 能刺激内皮细胞的生长 改善血管损伤，保障血流的流通 不过这项功能 也使得肿瘤细胞的生长加快 并逃离免疫组织的追捕 所以外泌体的促血管生成能力 是一把双刃剑 关键在于 我们如何正确精准的运用 用的好了 不仅能给心血管患者带来福音 还能作为早期肿瘤诊断的标志物 From this, we can conclude that exosomes have a strong ability to promote angiogenesis, mainly through the transmission of pro-angiogenic factors and the regulation of gene expression through miRNA. It has a positive effect on patients with heart and brain diseases, can stimulate the growth of endothelial cells, improve blood vessel damage, and ensure the circulation of blood flow. But this function also allows tumor cells to grow faster and escape the pursuit of immune tissue. Therefore, the ability of exosomes to promote angiogenesis is a double-edged sword, and the key lies in how we use it correctly and accurately. It can not only bring good news to cardiovascular patients, but also can be used as a marker for early tumor diagnosis. |
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