EWSR1-TFE3基因融合的肾细胞癌临床病理分析

一名57岁的日本女性，无病史，因全身疲劳而咨询初级保健医生。

Fig. 1 Histopathological features of the resected kidney. a The patient’s resected right kidney (left). The dotted lines and star(s) of the frontal plane indicate axial cut sections. The cut sections of the tumor (right). Each specimen indicated by star(s) corresponds to the axial section lined in the frontal plane. b Hematoxylin and eosin staining of the tumor. Alveolar nested tumors have thin capillary networks. Upper left region contains necrosis. c Higher magnification of the tumor. Enlarged polymorphic nuclei and eosinophilic or clear cytoplasm are observed. d–h Representative immunostainings. Tumor cells are diffusely positive for TFE3 (d), cathepsin K (e), PAX8 (f), EMA (g), and occasionally positive for α-methylacyl-CoA racemase (AMACR) (h).