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2022年Cell第15期没有一篇研究论文！但有多篇综述和评述文章，阐述了相关技术和科学研究之间相辅相成协同发展的概念。 推荐阅读：
On the cover: Technologies and creative methods are essential for research. They allow us to （uncover new aspects of ourselves and our surrounding world）and address what would otherwise be insurmountable problems【解决本来无法解决的问题，insurmountable 记忆技巧：in 不 + sur 超 + mount 登上；升 + able 能…的 → 不能超过的 → 难以克服的】. In this special issue, we explore how（ recently developed tools） can be used to （advance biological and bioengineering research） and highlight the unmet needs that future tools must address【强调未来工具必须解决的未满足的需求，换言之，目前的研究工具仍然不能满足我们所有的科研需求，但是这些问题将会随着技术的革新而得到解决】. We hope this special issue creates inspiration for technologies that—like a friendly robot—lift us higher, move us faster, and （carry us over obstacles） to help us achieve the impossible. Image credit: Naola Leconte. The integral partnership of biology and technology 生物学与技术的整体伙伴关系【现代技术与生物科学相互促进作用】 技术的发展对生物学和生物医学十分重要。变革性的发现往往伴随着新方法、工具或计算方法的开发和巧妙部署而来。相应地，技术进步往往受到生物系统的启发，或者需要开发一种方法来解决生物问题。
Tumor biology gets smart 【肿瘤生物变聪明了】 协同作用 : 两个或两个以上的组织、物质或其他因素的相互作用或合作，可以产生比它们各自作用的总和更大的联合效应。
Tackling human problems through biotechnology 【利用生物技术解决人类问题】 米歇尔 · 麦克默里-希思博士在医学、免疫学、研究和政策协调方面具有广泛的背景，她目前担任生物技术创新组织(BIO)的首席执行官。她与《细胞》杂志的编辑 Cheri Sirois 聊了聊生物技术与基础科学的区别，以及生物技术提供的机会。这里分享了他们的谈话记录。
The next decade of protein structure 随着蛋白质结构研究中各种技术的显著进步，我们请研究人员评论该领域下一个令人兴奋的问题，以及这些技术将如何不仅提高我们对蛋白质的认识，而且还提高我们对人类健康和疾病的认识。
The impact of AI on research 庞大而复杂的数据集使得人工智能(AI)成为跨生物学研究发现的无价工具。我们询问了专家人工智能如何影响他们的工作。他们的经验和观点为人工智能在他们领域提供的潜力提供了深刻的见解。
The challenges in finding your home as a multidisciplinary scientist 各种科学分支的技术进步正在应用于生命科学，导致越来越多的科学家认为自己是多学科的，或者被归类为多学科的。虽然他们的多样化技能被赞扬，并需要了解生活的巨大复杂性，作为一个多学科的研究人员可以提出独特的挑战。我们询问了多学科研究人员和一个促进多学科研究的研究所所长，他们对多学科科学家经常面临的挑战或障碍有何看法。
Establishing a blockchain-enabled Indigenous data sovereignty framework for genomic data 技术进步使健康和基因组数据得以迅速生成，尽管这些技术很少考虑到边缘化社区的价值观和优先事项。在这篇评论中，我们概念化了一个区块链基因组学数据框架的概念建立了数据主权。
Evolving ancient DNA techniques and the future of human history 应用于人类基因组学的古 DNA (aDNA)技术在过去的十年中取得了显著的进步，使得大规模的 aDNA 研究成为可能，有时独立于人类遗骸。本评论回顾了 DNA 技术的主要里程碑，并探讨了未来的方向，以扩大范围的 DNA 研究和见解，目前的人类健康。
Transcriptome, connectome and neuromodulation of the primate brain 单细胞转录组学分析促进了大脑中的细胞类型识别和细胞类型特异性连接体的映射，有助于阐明大脑功能的神经回路，并通过神经调节治疗脑部疾病。然而，我们缺乏一个共识的定义神经元类型/亚型和明确的区分因果之间的相互关联的网络。
The application of artificial intelligence to biology and neuroscience 在过去的十年里，人工智能(AI)经历了一场改变经济、社会和科学的革命。进展的速度是惊人的，几年前看似棘手的问题现在已经得到解决。神经科学和人工智能之间的交叉特别令人兴奋。
Tissue bioprinting for biology and medicine Bioprinting merges additive manufacturing and tissue engineering to generate functional tissues and organs. The field has experienced tremendous growth over the past few years. Here, we highlight recent breakthroughs in bioprinting and discuss the challenges that are yet to be addressed before this technology can be widely utilized in biology and medicine.
Cryo-electron tomography: A long journey to the inner space of cells Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail.
High current hydrogels: Biocompatible electromechanical energy sources Innovations in soft materials bridge electronic conduction in conventional electronics and ionic conduction in biology. In a recent issue ofScience, Dobashi et al. describe a hydrogel that generates large ionic currents in response to applied force. The technology could enable sensors and energy generators for wearable and implantable devices.
Repurposing chemical waste: Sustainable chemistry for circularity beyond artificial intelligence Generating considerable amounts of industrial waste requires rethinking chemistry for circularity in a broader picture. We discuss the study by Wołos etal. (2022) showing that the critical application of artificial intelligence on chemical reactivity can help us trace an unprecedented number of syntheses to novel responsible uses of waste.
Tools for mammalian glycoscience research 聚糖是复杂的、无处不在的、异质的，在生物学的基本过程中起着重要作用。Griffin 和 Hsieh-Wilson 提供了一个关键的概述，并讨论了目前用于鉴定，表征，监测和调节哺乳动物聚糖的方法，探索技术进步如何克服聚糖复杂性和异质性的困难，以提供更清楚的聚糖活性的中心特征。
Metabolic analysis as a driver for discovery, diagnosis, and therapy This review describes recent technical advancements in metabolic analysis over the last decade and how they have advanced understanding of metabolism in a variety of biomedical contexts.
3D genome, on repeat: Higher-order folding principles of the heterochromatinized repetitive genome Nearly half of the human genome is comprised of diverse repetitive sequences ranging from satellite repeats to retrotransposable elements. Such sequences are susceptible to stepwise expansions, duplications, inversions, and recombination events which can compromise genome function. In this review, we discuss the higher-order folding mechanisms of compartmentalization and loop extrusion and how they shape, and are shaped by, heterochromatin. Using primarily mammalian model systems, we contrast mechanisms governing H3K9me3-mediated heterochromatinization of the repetitive genome and highlight emerging links between repetitive elements and chromatin folding.
Synthetic chromosomes, genomes, viruses, and cells Synthetic genomics is a branch of synthetic biology that constructs viruses, bacteria, and eukaryotic cells with synthetic genomes. Venter and colleagues review the foundations, advances, challenges, and future prospects of synthetic genomics.
Single-cell approaches in human microbiome research 这篇综述介绍了最近开发的各种单细胞方法，用于研究该领域的正常菌群和其余挑战。
What is a cell type and how to define it? 在这篇综述中，曾教授讨论了从哺乳动物大脑中学到的见解如何开始揭示细胞类型的普遍组织原则，并提出了基于这些原则的路线图，用于采用多层次，迭代的方法来定义细胞类型，并产生跨寿命，物种，大脑和身体的细胞类型的知识库。
Human organoids: New strategies and methods for analyzing human development and disease This review highlights novel advances in organoid biology with a focus on how organoid technology has generated a better understanding of human-specific processes in development and disease.
Cancer vaccines: Building a bridge over troubled waters For many decades, vaccines have provided effective protection against a variety of infectious diseases. Attention is now focused on utilizing the power of the immune system to target tumors through the development of cancer vaccines. This review provides a background in how the immune system responds to cancer and how these immune responses can be harnessed for cancer vaccines and highlights some of the remaining challenges.
Designing antibodies as therapeutics Antibodies are a rapidly evolving class of drugs with the potential to treat a myriad of human diseases. Technological advances in areas such as protein engineering and drug delivery are enabling the design of antibodies that overcome some of the hurdles previously limiting their use as therapeutics in certain disease or clinical settings. This review highlights the major obstacles that have limited the use of antibodies as drugs and discusses how antibody design is overcoming these problems to unleash their full therapeutic potential.
Therapeutic in vivo delivery of gene editing agents Therapeutic gene editing has made exciting progress in the past few years, in part through key advances inin vivo delivery technologies. David Liu and colleagues review the essential characteristics required for efficient in vivo gene editing delivery vehicles, discussing the pros and cons of viral vectors, lipid nanoparticles, and virus-like particles.
The integrated genomics of crop domestication and breeding New genomic methods have advanced the understanding and capacity to manipulate plant genomes to accelerate future crop domestication and breeding needed to address the looming challenge of global food security.
SnapShot: Spatial transcriptomics Spatially resolved transcriptomics methodologies using RNA sequencing principles have and will continue to contribute to decode the molecular landscape of tissues. Linking quantitative sequencing data with tissue morphology empowers profiling of cellular morphology and transcription over time and space in health and disease. To view this SnapShot, open or download the PDF.
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