如果破坏了肿瘤的具核梭杆菌,癌细胞的增殖速度就会明显下降。这也给未来的癌症治疗提出了新的方向。 “越来越多证据显示口腔细菌与口腔外的肿瘤具备联系,这也说明口腔是许多致病微生物的栖息地。”分子微生物学家christopher Johnston博士表示,如果不注重口腔健康,那么在牙周或牙髓疾病发生时,细菌大量繁殖,随后它们可以演化并朝更多环境中转移,最后躲避免疫攻击,并帮助肿瘤一同逃避免疫系统。 参考资料:[1] Two new studies from Fred Hutchinson Cancer Center show how bacteria could help tumors progress and resist treatment. Retrieved November 16, 2022 from https://www./news-releases/971203[2] Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature (2022). DOI: https:///10.1038/s41586-022-05435-0[3] The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota. Cell Report. (2022). DOI: https:///10.1016/j.celrep.2022.111625