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Food odor perception promotes systemic lipid utilization
食物气味感知促进全身脂质利用 10.1038/s42255-022-00673-y 11-14, Article Abstract & Authors:展开 Abstract:收起
Food cues during fasting elicit Pavlovian conditioning to adapt for anticipated food intake. However, whether the olfactory system is involved in metabolic adaptations remains elusive. Here we show that food-odor perception promotes lipid metabolism in male mice. During fasting, food-odor stimulation is sufficient to increase serum free fatty acids via adipose tissue lipolysis in an olfactory-memory-dependent manner, which is mediated by the central melanocortin and sympathetic nervous systems. Additionally, stimulation with a food odor prior to refeeding leads to enhanced whole-body lipid utilization, which is associated with increased sensitivity of the central agouti-related peptide system, reduced sympathetic activity and peripheral tissue-specific metabolic alterations, such as an increase in gastrointestinal lipid absorption and hepatic cholesterol turnover. Finally, we show that intermittent fasting coupled with food-odor stimulation improves glycemic control and prevents insulin resistance in diet-induced obese mice. Thus, olfactory regulation is required for maintaining metabolic homeostasis in environments with either an energy deficit or energy surplus, which could be considered as part of dietary interventions against metabolic disorders.
First Authors:
Hiroshi Tsuneki,Masanori Sugiyama,Toshihiro Ito
Correspondence Authors:
Hiroshi Tsuneki,Teruhito Yasui,Toshiyasu Sasaoka
All Authors:
Hiroshi Tsuneki,Masanori Sugiyama,Toshihiro Ito,Kiyofumi Sato,Hiroki Matsuda,Kengo Onishi,Koharu Yubune,Yukina Matsuoka,Sanaka Nagai,Towa Yamagishi,Takahiro Maeda,Kosuke Honda,Akira Okekawa,Shiro Watanabe,Keisuke Yaku,Daisuke Okuzaki,Ryota Otsubo,Masanori Nomoto,Kaoru Inokuchi,Takashi Nakagawa,Tsutomu Wada,Teruhito Yasui,Toshiyasu Sasaoka
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