01 临床应用 02 特殊人群用药
03 不良反应 04 奥司他韦与疫苗 [13] 审核专家 专家点评 奥司他韦作为神经氨酸酶抑制剂的代表药物之一,抗病毒谱较广,包括甲型和乙型流感病毒以及禽流感病毒,适用人群也较为广泛,包括 1 岁以下的婴幼儿、早产儿,亦可用于妊娠期妇女。轻中度肝功能不全的患者无需调整剂量,重度肝功能不全者不建议使用;慢性肾功能不全患者应依据肌酐清除率减量后使用。不良反应以胃肠道反应为主,一般较为轻微,耐受性较好。 因此,即使在新型抗流感病毒药物不断涌现的当下,奥司他韦仍存在一定的临床优势。 参考文献(向上滑动查看) [1] Sur M, Lopez MJ, Baker MB. Oseltamivir. 2022 Sep 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30969731. [2] 成人流行性感冒抗病毒治疗共识专家组. 成人流行性感冒抗病毒治疗专家共识 [J/OL] . 中华传染病杂志, 2022,40:网络预发表. DOI: 10.3760/cma.j.cn311365-20220128-00325. [3] 陈新谦等. 陈新谦新编药物学 [M]. 北京: 人民卫生出版社,2018:110-1116. [4] 磷酸奥司他韦胶囊药品说明书. [5] COMMITTEE ON INFECTIOUS DISEASES. Recommendations for Prevention and Control of Influenza in Children, 2022-2023. Pediatrics, 2022,150(4):e2022059275. [6] COMMITTEE ON INFECTIOUS DISEASES. Recommendations for Prevention and Control of Influenza in Children, 2021-2022. Pediatrics, 2021, 148(4): e2021053745. [7] Chen Y, Ke M, Xu J, Lin C. Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling. AAPS PharmSciTech. 2020 Mar 03;21(3):98 [8] https://www./contents/oseltamivir-drug-information?search = Oseltamivir&source = panel_search_result&selectedTitle = 1~45&usage_type = panel&kp_tab = drug_general&display_rank = 1#F50991240 [9] Dawood FS, et al. Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study. Lancet Infect Dis. 2021 Jan;21(1):97-106 [10] ACOG Committee Opinion No. 753: Assessment and Treatment of Pregnant Women With Suspected or Confirmed Influenza: Correction. Obstet Gynecol. 2020 Mar;135(3):734. [11] Drugs and Lactation Database (LactMed) [Internet]. National Library of Medicine (US); Bethesda (MD): Mar 21, 2022. Oseltamivir. [12] Qin J, Lin J, Zhang X, Yuan S, Zhang C, Yin Y. Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children. Front Pharmacol. 2022 Apr 6;13:849545. [13] 奥司他韦的合理用药. 用药助手 APP. |
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