双氯芬酸是一种非甾体抗炎药(NSAID),临床上用于治疗与关节炎和痛风相关的炎症以及其他疼痛或炎症性疾病;它在抑制COX-2而不是COX-1方面具有一定的选择性。双氯芬酸具有抗炎、解热、镇痛、抗伤害感受、抗惊厥、抗血管生成、抗癌化疗和化学预防活性。体外,双氯芬酸的抗惊厥/抗癫痫活性可能源于抑制延迟整流器K+通道振幅和加速通道失活;它还增加了M型K+通道的振幅。该化合物抑制体内DMH诱导的结肠癌变,降低COX-2,VEGF和MCP-1的水平。双氯芬酸还减少上皮到间充质的转化(EMT),抑制鳞状细胞癌肿瘤的生长。 LKT Labs 双氯芬酸游离酸#D3210参数说明: Cas No.:15307-86-5 纯度:≥99% 公式:C14H11Cl2NO2 配方重量:296.15 化学名称:2-[(2,6-二氯苯基)氨基]苯乙酸 IUPAC名称:{2-[(2,6-二氯苯基)氨基]苯基}乙酸 同义词:伏尔塔罗尔 熔点:154-158°C 溶解度:不溶于水。溶于二甲基硅氧乙烷。 外观:白色至奶油粉末 LKT Labs-双氯芬酸游离酸文献引用: Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338. Akbari E, Mirzaei E, Shahabi Majd N. Long-term Morphine-treated Rats are more Sensitive to Antinociceptive Effect of Diclofenac than the Morphine-naive rats. Iran J Pharm Res. 2013 Winter;12(1):175-84. PMID: 24250586. Huang CW, Hung TY, Liao YK, et al. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol. 2013 Jun;64(3):269-80. PMID: 23959723. Kaur J, Sanyal SN. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog. 2011 Sep;50(9):707-18. PMID: 21268133. |
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