Inhibitors?Screening Libraries?ProteinsMedChemExpressVacquinol-1 dihyd
rochlorideCat. No.:HY-19345ACAS No.:2309312-85-2Synonyms:NSC13316
dihydrochloride分子式:C??H??Cl?N?O分子量:425.78作用靶点:Others作用通路:Others储
存方式:4°C, protect from light In solvent : -80°C, 6 months; -20°C
, 1 month (protect fromlight)BIOLOGICAL ACTIVITY生物活性Vacquinol-1 (
NSC13316) dihydrochloride 是一种 MKK4 特异性激活剂，可激活 MAPK 通路 [1]。 Vacqui
nol-1dihydrochloride 在多形性胶质母细胞瘤 (GBM) 小鼠模型中特异性诱导人胶质母细胞瘤细胞 (GC) 死亡
、减缓肿瘤进展并延长生存期 [2]。 Vacquinol-1 dihydrochloride 还诱导肝细胞癌 (HCC) 细胞凋亡
[3]。REFERENCESSun SL, Li X, Su N, et al. Vacquinol?1 induces apo
ptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):
557-563.Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducibl
e cell death in glioblastoma multiforme is counter regulated by T
RPM7 activityinduced by exogenous ATP. Oncotarget. 2017;8(21):351
24-35137.Chao Wu, et al. Salvianolic acid B exerts anti-liver fib
rosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at
linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:11
6881.Yufeng Shi, et al. The soft underbelly of tumor cells. Cell
Res. 2014 Aug;24(8):910-1.Shu-Lan Sun, et al. Vacquinol 1 induces
apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Ju
l;18(1):557-563.McePdfHeightCaution: Product has not been fully v
alidated for medical applications.For research use only.1/1Master
of Bioactive Molecules — 您身边的抑制剂大师 |
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