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2023+CSANZ立场声明:心脏康复中运动和体力活动的评估和处方临床指南
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Heart, Lung and Circulation (2023) -, -–-

1443-9506/23/$36.00

https://doi.org/10.1016/j.hlc.2023.06.854

POSITION STATEMENT

A Clinical Guide for Assessment and

Prescription of Exercise and

A CSAN

Christian Verdicchio,

Matthew Hollings

Alex Brown, PhD , David Colquhoun, MBBS, PhD ,

exercise

rehabilitation

use of

of aerobic ex-

and safety

C15 Exercise

for Heart Rhythm

HLC3932_proof ■ 24 July 2023 ■ 1/14

Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, SA, Australia; Email: christian.verdicchio@sydney.edu.au; Twitter: @c_verdicchio

1

Co-?rst authors

C211 2023 The Author(s). Published by Elsevier B.V. on behalf of Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac

Society of Australia and New Zealand (CSANZ). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Julie Redfern, PhD

a

a

Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia

b

Centre for Heart Rhythm Disorders, University of Adelaide, SAHMRI and Royal Adelaide Hospital, Adelaide, SA, Australia

c

Physiotherapy, Faculty of Health, University of Canberra, Canberra, ACT, Australia

d

Health Research Institute, University of Canberra, Canberra, ACT, Australia

e

Allied Health Department, Fiona Stanley Hospital, Perth, WA, Australia

f

Curtin School of Allied Health, Curtin University, Perth, WA, Australia

g

School of Population and Global Health, University of Western Australia, Perth, WA, Australia

h

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia

i

Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work,

Queensland University of Technology, Brisbane, Qld, Australia

j

Telethon Kids Institute, Australian National University, Canberra, ACT, Australia

k

Faculty of Medicine, University of Queensland, Brisbane, Qld, Australia

l

Faculty of Medicine, Wesley Medical Centre, Brisbane, Qld, Australia

m

Baker Heart and Diabetes Institute, Melbourne, Vic, Australia

n

Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Vic, Australia

o

UHasselt, REVAL/BIOMED (Rehabilitation Research Centre), Hasselt University, Hasselt, Belgium

p

Department of Exercise Sciences, University of Auckland, Auckland, New Zealand

Received 19 June 2023; accepted 27 June 2023; online published-ahead-of-print xxx

Patients with cardiovascular disease bene?t from cardiac rehabilitation, which includes structured

and physical activity as core components. This position statement provides pragmatic, evidence-based

guidance for the assessment and prescription of exercise and physical activity for cardiac

clinicians, recognising the latest international guidelines, scienti?c evidence and the increasing

technology and virtual delivery methods. The patient-centred assessment and prescription

ercise, resistance exercise and physical activity have been addressed, including progression

considerations.

Keywords Cardiac rehabilitation C15 Secondary prevention C15 Coronary disease C15 Cardiovascular disease

assessment C15 Exercise prescription C15 Physical activity C15 Position statement

Corresponding author at: Dr Christian Verdicchio, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Centre

Erin Howden, PhD

m,n

, Dominique Hansen, PhD

o

, Stacey Reading, PhD

p

,

Robyn Gallagher,

Please cite this article

Activity in Cardiac

10.1016/j.hlc.2023.06.854

Z Position Statement

PhD

a,b,1,

, Nicole Freene, PhD

c,d,1

,

, PhD

a,1

, Andrew Maiorana, PhD

e,f

, Tom Briffa, PhD

g

,

PhD

a

, Jeroen M. Hendriks, PhD

b,h

, Bridget Abell, PhD

i

,

j k,l

Activity in Cardiac Rehabilitation.

in press as: Verdicchio C, et al. A Clinical Guide

Rehabilitation. A CSANZ Position Statement.

Physical

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

assess the patient’s aerobic exercise capacity. Prior to per-

2 C. Verdicchio et al.

HLC3932_proof ■ 24 July 2023 ■ 2/14

Introduction

Cardiovascular disease (CVD) is the leading cause of death

and disease burden globally [1]. Improvements in diagnosis,

treatment and long-term management have improved survi-

vorship and reduced hospitalisations following a cardiac

event,howevertheyhavealsogreatlyincreasedthenumberof

patients requiring ongoing and lifelong CVD risk manage-

ment [2,3]. To reduce the risk of future events, international

guidelinesrecommendalleligiblepatientshaveaccessto,and

participate in, secondary prevention programs, including

cardiac rehabilitation [4,5]. Cardiac rehabilitation is a

comprehensive, multidisciplinary intervention consisting of

patient assessment and individualised risk pro?le manage-

ment, dietary advice, exercise prescription and physical ac-

tivity counselling and psychosocial support [6]. The National

HeartFoundationofAustralia,theAustralianCardiovascular

Health and Rehabilitation Association (ACRA) and the Na-

tional Heart Foundation of New Zealand all promote cardiac

rehabilitation and have online resources that can provide re-

ferrers with a list of local services available for their patients.

Exercise-based cardiac rehabilitation has demonstrated effec-

tiveness for reducing hospitalisations and myocardial infarc-

tion rates, whilst improving risk pro?le, exercise capacity and

quality of life in patients with coronary disease [7,8]. Exercise

programmingalsobene?tspatientswithothercardiovascular

conditions such as heart failure (both reduced and preserved

ejection fraction) [9,10], atrial ?brillation [11], peripheral

vascular disease [12], congenital heart disease [13], valve dis-

ease [14], pulmonary hypertention [15] and, more recently,

with cardio-oncology patients [16].

A graduated program of structured exercise and physical

activity is a core component of comprehensive cardiac reha-

bilitation [17]. Recent studies have described new exercise

trainingtechniques,whichhaveimprovedourunderstanding

of the physiological adaptations from exercise training across

diverse patient groups. Furthermore, recent data have also

provided a greater understanding of technology and virtual

delivery methods for the prescription of exercise and physical

activity within cardiac rehabilitation programs. A patient-

centred approach is important, and communication with pa-

tients should be non-judgemental and respectful. Shared de-

cision making, where patients and their carers are actively

involved in the care process, results in personalised in-

terventions that are more likely to improve engagement,

treatment adherence, and clinical outcomes [18]. Concomi-

tantly, health professionals should consider evidence, guide-

lines and behaviour change theories, techniques, and tools

when collaborating with patients, identifying their individual

exercise and physical activity needs, values and preferences.

Realistic short- and medium-term goal setting may be

considered,andfollow-upshouldbediscussedandsupported

by the entire multidisciplinary team as they are central to the

patient’s rehabilitation journey [18].

The objective of this position statement is to provide

pragmatic, evidence-based guidance for the assessment and

prescription of exercise and physical activity by all clinicians

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

forming any exercise assessment, it is imperative that clini-

cians consider all relevant contraindications (Table 1). The

gold-standard assessment for aerobic exercise capacity is a

cardiopulmonary exercise test (CPET) conducted on either a

treadmill or cycle ergometer with gas analysis. However, this

test is limited to predominantly tertiary centres in Australia

and New Zealand due to the cost and specialised equipment

and staff required to conduct it. Several methods for

assessing aerobic exercise capacity and functional exercise

capacity, and the pros and cons of each are summarised in

Table 2.

Prescribing and Progressing Aerobic

Exercise

Figure 1 summarises the recommended clinician work?ow in

working within cardiac rehabilitation (e.g., exercise physiol-

ogists, nurses, physiotherapists) in the Australian and New

Zealand context. Speci?cally, the aim is to summarise the

assessment and prescription recommendations for aerobic

exercise, resistance exercise and physical activity for all pa-

tients referred for secondary prevention of their recent car-

diac event or a new diagnosis. To do this, a multidisciplinary

writing group was convened comprising of experts from

relevant disciplines, with regional, gender and cultural rep-

resentation to ensure diversity. A consensus process was

then followed to draft, review, and re?ne the document. The

position paper was then submitted to the Cardiac Society of

Australia and New Zealand, ACRA, Exercise and Sports

Science Australia, and the Australian Physiotherapy Asso-

ciation for endorsement.

Aerobic Exercise

Aerobic exercise is de?ned as any activity that uses large

muscle groups that can be maintained continuously and is

rhythmic in nature [19]. Common forms of aerobic exercise

include walking, jogging, cycling, rowing and swimming.

The bene?ts of aerobic exercise training within cardiac

rehabilitation are well established [7,8]. Cardiometabolic

bene?ts include (but are not limited to) improved insulin

sensitivity and glycaemic control, reduction in in?ammatory

markers, reduced visceral fat, improved vascular function

and blood pressure control, improved lipid metabolism,

improved skeletal muscle structure and function and modest

improvements in left ventricular function [10,20,21].

Assessment

The ACRA cardiac rehabilitation core components state that

all patients should receive “an individualised initial assess-

ment that includes physical, psychological and social pa-

rameters” [17]. This assessment enables the development and

implementation of an individualised exercise program based

on the aerobic exercise or functional capacity of the patient.

An aerobic exercise assessment should be conducted to

relation to assessment, prescription and progression of

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

and

Relative

2 kg

Concurren

Decrease

NYHA

Complex ventricular arrhythmia at rest or appearing with

exertion

Supine

Moderate

Blood

case

Sternal

separate

Exercise in Cardiac Rehabilitation 3

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Table 1 Absolute and relative contraindications to exercise

Absolute Contraindications

Progressive worsening of exercise tolerance or dyspnoea at

rest or on exertion

over previous 3–5 days (uncompensated heart failure)

Unstable angina

Blood glucose ,4.0mmol/L or .15.0mmol/L with

symptoms of weakness/tiredness, or with ketosis

Acute systemic illness or fever

Recent embolism (,4 weeks)

Thrombophlebitis

Active pericarditis or myocarditis

Severe symptomatic aortic stenosis

Regurgitant valvular heart disease requiring surgery

Previously undiagnosed atrial ?brillation

Sternal Instability Scale grade 3 (completely separated)

Resting heart rate .120 bpm

aerobic exercise training. Informed by a comprehensive

clinical history and exercise assessment, the fundamental

principles of exercise prescription should be applied: Fre-

quency, Intensity, Time, Type, Volume and Progression

(FITT-VP) [22]. Frequency (F) considers how often the patient

completes the exercise. Intensity (I) is the level of effort the

patient should be exercising at based on assessment of their

exercise capacity. Absolute intensity refers to the energy

required to perform an activity (e.g., caloric expenditure,

absolute oxygen uptake, metabolic equivalent of task).

Whereas relative intensity refers to the energy cost of the

activity relative to the individual’s maximal capacity (e.g., %

maximum oxygen consumption or heart rate reserve,

perceived exertion). For individualised exercise prescription,

a relative measure of intensity is recommended, especially

for deconditioned individuals [22]. Time (T) is the duration

of each exercise session. Type (T) is the mode of exercise to be

completed. Volume (V) is the total amount of exercise

training, a product of frequency, intensity and time. Pro-

gression is the commencement, advancement and progres-

sion of intensity or volume over time [15]. It is important to

highlight that rest or recovery within and between sessions

should also be promoted for patients to maximise their

overall health status and adaptations to exercise. Table 3

provides FITT-VP recommendations for an individually

tailored aerobic exercise prescription at a moderate-high in-

tensity. Table 4 provides a summary of the de?nitions of

light, moderate, high, and very-high intensities when

assessing or prescribing exercise or physical activity.

Moderate-Intensity Continuous Training

Versus High-Intensity Interval Training

In Australia and New Zealand, exercise prescription guide-

lines for cardiac rehabilitation have historically been more

conservative compared to those in Europe and America,

focussing on low-to-moderate intensity exercise, with less

technical assessment of aerobic capacity [23]. Moderate-

intensity continuous training (MICT) is bene?cial and safe

for all patients with coronary disease and is strongly rec-

ommended [6,24]. More recently, high-intensity interval

Orthostatic blood pressure drop of .20 mmHg with

symptoms

Third-degree atrioventricular block without pacemaker

Adapted from HeartOnline [52]; American College of Sports Medicine Guidelines for Exercise Testing and Prescription [22]; El-Ansary et al. [34].

During recovery, limit to light to moderate intensity exercise until left ventricular dysfunction has resolved.

#

Relative contradictions are a guide only and should be combined with clinical judgement at every session. If in doubt, medical advice should be sought before

commencing an exercise or physical activity assessment or session.

ˇ

Rapid weight gain may be a red ?ag for heart failure.

Abbreviation: NYHA, New York Heart Association.

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide for Assessment and Prescription of Exercise and Physical

Activity in Cardiac Rehabilitation. A CSANZ Position Statement. Heart, Lung and Circulation (2023), https://doi.org/

10.1016/j.hlc.2023.06.854

resting heart rate C21100 bpm

aortic stenosis

pressure .180/110 mmHg (evaluated on a case-by-

basis)

Instability Scale grade 1–2 (minimally to partially

d sternum)

physical activity.

Contraindications

#

increase in body mass over previous 1–3 days

ˇ

t continuous or intermittent dobutamine therapy

in systolic blood pressure with exercise

functional class IV

Table 2 Types of aerobic exercise, muscle strength and physical activity assessments.

Type of assessment Description Pros Cons

Aerobic Capacity

Cardiopulmonary Exercise Test (CPET) Incremental treadmill (Modi?ed Bruce,

Naughton, Balke protocols [52]), or leg/

arm ergometer test (Ramp protocol) with

concomitant expired air analysis.

Gold standard

Valid and reliable

Tailored exercise prescription

Investigates the physiology of exercise

intolerance [53]

Assesses ventilatory responses to

exercise

Assesses ventilatory thresholds (VT1 and

VT2)

Heart rate response to peak exercise

Blood pressure response

Peak VO

2

prognostic marker

Requires supervision by an allied health

professional with extensive experience

and training in the ability to interpret an

electrocardiogram [54]

Medical Practitioner on site [55]

Generally limited to tertiary medical

centres, often with specialist cardiac

services

Expensive equipment required

Graded Exercise Test Treadmill or leg/arm ergometer test

following a standardised protocol (e.g.,

Balke, Naughton or Bruce Protocols [56]).

Test may be ceased once the patient

reaches 85% of their age predicted HR

max

(65% for those with beta-blockade

therapy who are well rate controlled

during exercise), or if clinically indicated;

e.g., chest pains, dyspnoea, light-

headedness, or fatigue [22,55,56]

Assessment of haemodynamic response

to exercise

Tailored exercise prescription

Easy to implement

Lower cost than CPET

Peak METs prognostic

Requires quali?ed supervision

Inability to walk on slowest treadmill

speed

Functional Exercise Capacity/Field

Tests

Incremental Shuttle Walk Test:

Incremental walking test between the

two cones 10 m apart timed to an audio

signal (beep). Patient walks as long as

possible or can no longer keep up with

the beeps [57].

Six-Minute Walk Test (6MWT):

Low-resource test that involves walking

as far as possible in 6 minutes, along a

20–30m ?at track. Calculate average

speed (km/hr) to guide exercise

prescription = (6MWT distance x10)/

1000.

Valid and reliable

Externally paced

Low-cost requiring minimal equipment

Assessment of physiological indices

Tailored exercise prescription

Well established [17]

Prognostic

Easy to comprehend and perform

Suitable for the less agile

Assessment of physiological indices

Tailored exercise prescription

Minimal resources

Blood pressure and heart rate monitoring

External audible timed signal

More complex than 6MWT

Unsuited for those unable to walk at least

1.8 km/hr

Submaximal test as patient unlikely able

to reach higher intensities

Limited tool to prescribe exercise

intensity targets

Sensitivity

4

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et

al.

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2023



4/14

Please

cite

this

article

in

press

as:

Verdicchio

C,

et

al.

A

Clinical

Guide

for

Assessment

and

Prescription

of

Exercise

and

Physical

Activity

in

Cardiac

Rehabilitation.

A

CSANZ

Position

Statement.

Heart,

Lung

and

Circulation

(2023),

https://doi.org/

10.1016/j.hlc.2023.06.854

Table 2. (continued).

Type of assessment Description Pros Cons

Muscle Strength

1RM assessments De?ned as the maximum weight that can

be lifted for one-repetition, through the

full available range of motion and with

an acceptable level of technical

pro?ciency

Completed for any major muscle group

and requires either machine weights or

free weights

Test terminated when patient is unable to

perform one acceptable repetition on two

consecutive attempts

Good–excellent test-retest reliability

regardless of age, sex, experience level or

muscle group [58]

Safe and tolerable for cardiac

rehabilitation patients [59,60]

May limit the haemodynamic excursions

seen in higher repetition assessments [61]

Results can directly inform exercise

prescription

Requires machine or free weights with

adequate available loading, which can be

costly

Requires supervision of appropriately

trained and experienced clinicians

Risk of musculoskeletal complications

Estimated 1RM assessments Uses validated prediction equations [62]

to estimate 1RM based on a multiple

repetition test

Multiple repetition test = the highest

weight that can be lifted for a speci?ed

number of repetitions to failure (e.g., a 3–

6-repetition maximum test)

Higher reliability with lower repetition

tests (C206 reps)

Same equipment, range of motion,

technical pro?ciency and termination

criteria as standard 1RM test

Lower loads may suit equipment

limitations or patient/clinician hesitancy

Safe and tolerable for cardiac

rehabilitation patients [59,60]

Results can directly inform exercise

prescription

Some error associated when population-

level estimation equations used to

predict individual outcomes

Requires machine or free weights with

adequate available loading, which can be

costly

Requires supervision of appropriately

trained and experienced clinicians

Low-resource assessments The general principle of these

assessments is for patients to either:

(1) complete a speci?ed number of

repetitions in the fastest possible time

(e.g., 5 sit-to-stands for fastest time), or

(2) complete the highest number of

repetitions in a speci?ed period of time

(e.g., maximum number of sit-to-stands

in 30 seconds)

Easily implemented across most CR

settings

Minimal equipment requirements

Repeatable, objective measurement of

muscular strength or endurance

Outcome not transferrable to resistance

exercise equipment for prescription

Exercise

in

Cardia

c

Rehabilitation

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Please

cite

this

article

in

press

as:

Verdicchio

C,

et

al.

A

Clinical

Guide

for

Assessment

and

Prescription

of

Exercise

and

Physical

Activity

in

Cardiac

Rehabilitation.

A

CSANZ

Position

Statement.

Heart,

Lung

and

Circulation

(2023),

https://doi.org/

10.1016/j.hlc.2023.06.854

Table 2. (continued).

Type of assessment Description Pros Cons

Physical Activity

Pedometers Research vs consumer pedometers

Range in functionality and accuracy and

are often found in smartphones or

smartphone apps

Less prone to recall error and bias [63]

Output (steps) is simple to understand

Consumer pedometers have reasonable

accuracy for steps [64]

Unable to determine context of activity

Insensitive to non-ambulatory and water

activities (e.g., cycling, swimming) [63]

Output does not capture intensity

Accelerometers Research vs consumer accelerometers

Capture acceleration of movement in one

or more planes, as well as steps

Provides a measure of intensity, allowing

an overall measure of activity volume

(i.e., MVPA minutes/week)

Accelerometer intensity thresholds may

not be appropriate for cardiac

populations

Inclinometers Research vs consumer inclinometers

Measure postural transitions, recording

time in sitting/lying, standing and

stepping

Considered the most accurate measure of

sedentary behaviour

Physical activity and Sedentary

Behaviour questionnaires

Long-format International Physical

Activity Questionnaire [65] (group level

measure)

Active Australia Survey [66] (group level

measure)

Physical Activity Vital Sign [67]

(clinically feasible, individual level

measure)

Past-day Adults’ Sedentary Time

questionnaire [68] (group level measure)

More practical due to their low cost and

ease of use in the clinical setting

Past-day Adults’ Sedentary Time

questionnaire has been validated in the

cardiac rehabilitation setting

More likely to under or over-estimate

physical activity and sedentary time due

to recall bias

Tend to show low correlations with

objective measures

No physical activity questionnaires have

been validated in the cardiac

rehabilitation setting

Activity diaries At an individual level, activity diaries

can also be used

Labour intensive for participants [69]

Abbreviations: METs, metabolic equivalents; VT1, ventilatory threshold 1; VT2, ventilatory threshold 2; VO

2

, volume of oxygen consumption; 1RM, 1 repetition-maximum; MVPA, moderate-to-vigorous physical

activity.

6

C.

Verdicchio

et

al.

HLC3932_

proof



24

July

2023



6/14

Please

cite

this

article

in

press

as:

Verdicchio

C,

et

al.

A

Clinical

Guide

for

Assessment

and

Prescription

of

Exercise

and

Physical

Activity

in

Cardiac

Rehabilitation.

A

CSANZ

Position

Statement.

Heart,

Lung

and

Circulation

(2023),

https://doi.org/

10.1016/j.hlc.2023.06.854

and

frequency

activity.

Exercise in Cardiac Rehabilitation 7

HLC3932_proof ■ 24 July 2023 ■ 7/14

training (HIIT) has also been recommended and deemed safe

by international authorities for various patients with stable

cardiac disease and may provide superior outcomes

Figure 1 A practical guide for the assessment, prescription

physical activity.

Abbreviations: CPET, cardiopulmonary exercise test; FITT-VP,

of perceived exertion; MVPA, moderate-to-vigorous physical

compared to MICT [25–27].

If appropriate, moderate- and high-intensity training can

be prescribed interchangeably as patients progress, while

considering patients’ preferences and ability, and can be a

good combination to improve a patient’s aerobic exercise

capacity [28]. MICT is recommended for those patients with

low aerobic exercise capacity and, where appropriate, pa-

tients could be progressed to high intensity sessions as their

aerobic exercise capacity improves. Select patients with sta-

ble coronary disease, and a good level of aerobic exercise

capacity, may progress to high-intensity exercise after a brief

period of moderate-intensity exercise training. The most

commonly used HIIT model is a warm-up, followed by 4x4-

min intervals at 75%–90% peak heart rate (HR

peak

) with an

active recovery phase of 3-min between bouts at approxi-

mately 60% HR

peak

, followed by a cool-down [28]. However,

a ?exible approach, tailored to individual requirements is

judicious in practice, such as shorter intervals and/or a lower

intensity for patients who have a reduced aerobic capacity

and who may be unable to complete a full 4-min workload

[28].

Resistance Exercise

Resistance exercise requires the contraction of one or more

muscle groups against an external resistance (e.g., weights)

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

with the intention to enhance muscular adaptions such as

strength,massandendurance[22].Participationinstructured

resistance exercisesessions,knownasresistance training,also

progression of aerobic exercise, resistance exercise and

intensity time type volume progression; RPE, rate

improves functional performance and prognosis for patients

with heart failure [29] or coronary artery disease [30].

Resistance training is an important aspect of an exercise

program for the diverse and ageing cardiac rehabilitation

population, offering unique bene?ts that are not provided by

aerobic exercise training. Speci?cally, resistance training can

prevent or reverse the loss of muscle mass (sarcopenia) that

occurs after coronary artery bypass grafting and with older

age, and can also bene?t comorbid metabolic, vascular,

cognitive, frailty and mental health conditions [31]. More-

over, the addition of resistance training to aerobic exercise

programs enhances both muscular strength and aerobic ca-

pacity adaptations in patients with coronary disease [32].

Despite historical concerns regarding safety, resistance ex-

ercise is well tolerated by patients with cardiovascular con-

ditions, with very few adverse cardiovascular events

reported [32] and acute haemodynamic changes comparable

to aerobic exercise [33].

Assessment

The objective assessment of muscle strength in cardiac

rehabilitation is important to determine and quantify base-

line muscle strength, guide individual prescription, and

evaluate changes in muscular strength. It is critical that cli-

nicians consider all relevant contraindications before con-

ducting any resistance exercise testing (Table 1), including

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

Table 3 FITT-VP Recommendations for prescribing aerobic exercise, resistance exercise and physical activity in cardiac disease patients.

Aerobic Exercise Resistance Exercise Physical Activity

All recommendations should primarily be based on patient need and preference and individual risk assessment

Frequency 3 or more days per week [6]. For patients

completing HIIT, at least two of these sessions per

week are recommended to be high intensity.

2–3 sessions per week. Recommend 48 hours

between sessions, where possible, to maximise

muscular recovery

MVPA should be completed on most days per

week, which includes exercise as a subset.

Intensity Moderate-to-high intensity (Table 4; e.g., 55%–90%

HRmax, RPE 12–16) based on assessment of aerobic

capacity (Table 2)

Moderate-to-high intensity (Table 4; e.g., 50%–80%

1RM or 5–7 RPE based on assessment of muscular

performance.

Initial prescriptions recommended at moderate

intensity for patients not experienced in resistance

training

MVPA is recommended to meet the physical

activity guidelines. Patients can use the Borg RPE.

Modi?ed RPE or the Talk Test to monitor how hard

they are working (Table 4)

Time Session duration .30 min of total aerobic exercise.

For patients who are severely deconditioned or

have symptoms at low workloads, it is

recommended to start with bouts of light-moderate

continuous exercise of 5–10 min in duration with

breaks as required, to allow full recovery and

repeat 2–3 times, progressing towards 30 min of

continuous activity. Once moderate intensity

activities are tolerated, patients should be

encouraged to exercise at higher intensities

Session duration: .20 min

Duration of muscle contraction .4 second per

repetition (.1 s concentric phase, .3 s eccentric

phase)

Rest between sets: 60 s [70]

150–300 min moderate intensity, or 75–150 min

vigorous intensity, or a combination of both, per

week is the aim. This does not need to be

accumulated in 10-minute bouts.

Additionally, break up long periods of sedentary

time, replacing with any intensity of physical

activity, including light intensity.

Type A variety of aerobic modes of exercise are

recommended that use large muscle groups such as

walking, jogging, cycling, swimming, rowing, stair

climbing.

Arm-ergometry can also be used if there are

underlying musculoskeletal issues affecting lower

limb use.

Whole body, single- or multi-joint exercises,

performed bilaterally where possible. May include

a range of modalities including bodyweight, free-

weights, machine weights and elastic resistance

bands.

Altering the type of resistance training performed

can be a useful way to manipulate intensity

through changes in body position and loading,

particularly in low-resource settings

A variety of MVPA is recommended including

domestic, occupational, transportation and leisure

activities.

Explore opportunities to increase physical activity

within the individual’s existing daily routines,

encouraging activities that the individual enjoys.

Be aware of local physical activity referral

opportunities (e.g., Heart Foundation walking

groups, Parkrun), if appropriate.

Volume A minimum of 150 minutes of moderate-high

intensity aerobic exercise, with an ideal target of

.210 min per week for increased cardiometabolic

bene?t[71]

Total session volume per major muscle group =

15–36 repetitions, arranged as 1–3 sets of 8–15

repetitions.

Initial prescriptions can consider lower volumes to

allow patient familiarisation prior to progressing

towards higher volumes

C21150 min MVPA per week; C217,500 steps/day [72]

8

C.

Verdicchio

et

al.

HLC3932_

proof



24

July

2023



8/14

Please

cite

this

article

in

press

as:

Verdicchio

C,

et

al.

A

Clinical

Guide

for

Assessment

and

Prescription

of

Exercise

and

Physical

Activity

in

Cardiac

Rehabilitation.

A

CSANZ

Position

Statement.

Heart,

Lung

and

Circulation

(2023),

https://doi.org/

10.1016/j.hlc.2023.06.854

Table

3.

(continued).

Aero

bic

Exerc

ise

Resistance

Ex

ercise

Physica

l

Act

ivity

Progres

sion

Star

t

slow

ly

and

progre

ss

gra

dually

,

increas

ing

durat

ion

to

meet

30

min

befo

re

increasing

intensity.

Incr

eases

in

intensity

and

duration

of

5%



10%

ever

y

1



2

weeks

are

typically

well

-tolerated

within

cardi

ac

patients.

Clinic

ians

shoul

d

progress

a

t

leas

t

one

of

the

followi

ng

to

optimise

resistance

training

adapt

ations:

volum

e

(reps,

sets

),

intensity,

type,

freq

uency.

Volu

me

and

intensity

should

be

progre

ssed

befo

re

other

training

vari

ables.

E.g.,

Prog

ress

repetitions

befo

re

sets

or

in

tensity,

up

to

a

m

aximu

m

o

f

15.

Once

15

reps

can

be

comp

leted

with

ease,

then

in

tensity

sh

ould

be

progressed

to

4



6

o

n

RPE

scale

at

a

new

targe

t

o

f

8



10

reps.

Inten

sity

should

then

be

progre

ssed

towar

ds

the

highe

st

tolerable

in

tensity

and

sets

progressed

towar

ds

3

per

m

ajor

m

uscle

grou

p.

Start

slowly

and

prog

ress

grad

ually,

increasing

duration

befo

re

intensity.

If

appropriate,

indivi

duals

m

a

y

start

w

ith

as

little

as

2



5

m

inutes

of

activi

ty,

3



4

times

a

day.

Progre

ss

toward

s

3

0

min

o

f

m

oderate

in

tensity

ph

ysical

activity

or

7,50

0

steps

on

most

days,

noting

any

activity

is

bette

r

than

non

e

Abbreviations:

HIIT,

high-intensity

interval

training;

MICT,

moderate-intensity

continuous

training;

HR

max,

Maximal

heart

rate;

MVPA,

moderate-to-vigorous

physical

activity;

RPE,

rate

of

perceived

exertion;

reps,

repetitions.

Exercise in Cardiac Rehabilitation 9

HLC3932_proof ■ 24 July 2023 ■ 9/14

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

the sternal stability of post-sternotomy patients prior to

commencing upper body resistance training [34].

Muscle strength should be assessed or estimated relative to

the 1-repetition maximum (1RM) outcome measure. Several

alternative methods for the assessment of muscle strength

are summarised in Table 2, where individual service-level

factors like equipment availability and clinician experience

may limit the accessibility of 1RM assessment. It is important

to note these alternative methods are limited in their ability

to inform exercise prescription.

Prescribing and Progressing Resistance

Exercise

Figure 1 summarises the recommended clinician work?ow in

relation to assessment, prescription and progression of aer-

obic exercise training. Prescription of resistance training

during cardiac rehabilitation should be informed by the re-

sults of a comprehensive assessment and align with the dual

principles of resistance training programming: individuali-

sation and progression [26]. Individualisation refers to

tailoring the resistance exercise prescription speci?ctoa

patient’s physical capacity, experience, preference and car-

diac history. Progression is the application of the progressive

overload principle and it refers to the increases in intensity or

volume over time that is essential for promoting muscle

adaptions to exercise. Prescription recommendations for

resistance training are summarised in Table 3 and exercise

intensities in Table 4.

Anobjectivemeasurementofmuscularstrength(e.g.,1RM)

for each of the available equipment types or movements fa-

cilitates accurate initial exercise intensity prescription [26]. In

the absence of objective data for all movements, the most

relevant subjective measurement to inform prescription and

progression of resistance exercise is the rating of perceived

exertion(RPE)(Table4).ScalesincludetheBorgandOmnibus

Resistance Exercise Scale (OMNI-RES) for rating perceived

exertionthatallowpatientstoratetheirownperceivedlevelof

exertionfrom1–10(10ismaximal)usinganumberorpictorial

toolthathavebeenvalidatedagainstothersubjectivescalesfor

use speci?cally in resistance exercise [35].

Many patients will have had limited exposure to resistance

exercise prior to cardiac rehabilitation enrolment. Thus, it is

important for patients to develop good technical pro?ciency

during the initial training sessions, to set the technical

foundation and allow for the safe progression of resistance

exercise load and volume throughout the program [26].

Clinicians are encouraged to initially provide a demonstra-

tion and then communicate with and coach the patient

throughout the exercise delivery to facilitate skill acquisition

and body awareness. Thus, clinicians should embed clear,

concise instructions for each exercise and simple, consistent

feedback at the conclusion of each set. Patients should also be

advised that: (1) breath-holding (Valsalva manoeuvre)

should be avoided during resistance exercise to limit blood

pressure excursions; (2) muscle tension during resistance

exercise is a normal sensation; and (3) muscle soreness is

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

(MVPA) and step counts. Table 2 outlines methods for

Table

4

Aerobic

exercise,

physical

activity

and

resistance

training

intensities.

Light

Intens

ity

Mo

derat

e

I

n

tensity

Hi

gh/Vigo

rous

Intens

ity

Very

High

Intensity

Aerob

ic

exercise/p

hysica

l

activ

ity

VO

2max

[

26

]

(%)

,

40

40



69

70



85

.

85

HR

max

(%)

,

55

55



74

75



90

.

90

HRR

(%)

,

40

40



69

70



85

.

85

6MW

T

averag

e

spee

d



[

73

]

(%)

80

100

Bo

rg

RPE

10



11

12



13

14



16

17



19

Mo

di

?

ed

RPE

2



34



67



89

Ta

lk

tes

t

[

74

]

Able

to

sing

Abl

e

t

o

talk

in

full

sentence

s/

un

able

to

sing

Una

ble

to

talk

comf

ortably

R

esistan

ce

trainin

g

1

R

M

(%)

,

50

50



69

70



84

C21

85

OM

NI-RP

E

[

35

]

,

55

6



7

C21

8

These

intensities

may

be

an

underestimate

in

?

tter

individuals

in

whom

the

test

is

submaximal.

Abbreviations:

VO

2max,

maximal

oxygen

capacity;

HR

max,

Maximal

heart

rate,

HRR,

heart

rate

reserve;

6MWT,

6-minute

walk

test;

RPE,

rate

of

perceived

exertion;

1RM,

1

repetition

maximum.

10 C. Verdicchio et al.

HLC3932_proof ■ 24 July 2023 ■ 10/14

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

assessing physical activity and sedentary behaviour in clin-

ical practice.

Prescribing and Progressing Physical

Activity

Figure 1 summarises the recommended clinician work?ow in

common in the ?rst few days after resistance exercise but is

reduced with subsequent exposures [26]. The recommenda-

tion for preliminary sessions is to commence at lower ranges

of the recommended intensity so that patients can primarily

focus on technique without being hampered by muscular

fatigue [26].

Physical Activity

Physical activity is de?ned as any bodily movement pro-

duced by skeletal muscles that result in energy expenditure

such as walking for transport, dancing, housework, or

gardening; with exercise as a subset [36]. Sedentary behav-

iour is any waking behaviour characterised by an energy

expenditure C201.5 metabolic equivalents (METs), while in a

sitting, reclining, or lying posture [37]. In people with coro-

nary disease, physical inactivity and sedentary behaviour are

risk factors for cardiovascular and all-causes of death [38,39].

Active people with coronary disease have a 50% lower risk of

mortality, compared to inactive counterparts [38]. Addi-

tionally, suf?cient physical activity reduces the impact of

coronary disease, slows its progress and improves modi?-

able risk factors for recurrent CVD and other chronic disease

[40]. Consequently, individuals undertaking cardiac reha-

bilitation and secondary prevention interventions are

encouraged to meet the public health physical activity

guidelines to improve health outcomes [17].

The World Health Organization physical activity guide-

lines for adults with chronic disease recommend that in-

dividuals should complete 150–300 minutes of moderate

intensity aerobic physical activity; or 75–150 minutes of

vigorous intensity aerobic physical activity or a combination

of both per week [41]. Muscle strengthening should be

completed on at least two days per week and varied func-

tional balance and strength activities should be completed

three days per week. In addition, long periods of sedentary

time should be avoided, replacing sedentary time with any

intensity of physical activity, including light intensity, and,

for those who ?nd it dif?cult to meet guidelines, any activity

is better than none [41,42].

Assessing Physical Activity

Physical activity and sedentary behaviour can be assessed

subjectively (e.g., questionnaire) or objectively (e.g., pedom-

eter, accelerometer) to determine whether an individual is

inactive (i.e., not meeting the physical activity guidelines).

The most common metrics used to measure physical activity

are minutes of moderate-to-vigorous physical activity

relation to assessment, prescription and progression of

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

Regardless of diagnosis, whether there has been an acute

cardiac event or procedure, comorbidities or age, all in-

move in the tube” is a paradigm shift that promotes upper

Exercise in Cardiac Rehabilitation 11

HLC3932_proof ■ 24 July 2023 ■ 11/14

dividuals should be encouraged to increase their exercise and

physical activity levels safely, starting slowly at an appro-

priate level and progressing gradually [6,41]. It is recom-

mended that when conducting centre-based exercise sessions

there are basic safety standards and procedures in place,

such as a de?brillator, resuscitative and ?rst-aid equipment

on-site. Prior to each supervised exercise session, it is rec-

ommended to assess the patient’s contraindications to exer-

cise, measuring pre-exercise heart rate and blood pressure, to

ensure that they are within an acceptable range at rest

(Table 1). However, as patients progress and their cardiac

disease is stable with no symptoms, these pre-exercise mea-

surements are not necessary and may be counterproductive

to the patient’s feelings around exercise and physical activity

in an unsupervised state. Clinical risk may increase over time

due to disease progression or clinical deterioration. When in

doubt, seek medical advice or support before commencing

the exercise session. During exercise it is recommended to

monitor the patient’s heart rate and RPE (or Borg Scale for

Dyspnoea in patients with heart failure) to ensure they are

reaching their target intensity during their aerobic bout of

exercise and responding to exercise appropriately (Figure 1).

ECG monitoring during exercise is not essential for patients

within the supervised setting; however, in certain circum-

stances (e.g., atrial ?brillation, history of signi?cant ventric-

physical activity. Following a comprehensive assessment of

an individual’s physical activity levels and their safety to

increase these levels (Table 1), physical activity can be pre-

scribed according to the FITT-VP principle. An individual’s

goals, motivation and con?dence to increase physical activity

in everyday life should be reviewed as part of a compre-

hensive assessment, with each patient receiving an individ-

ually tailored physical activity program based on these

?ndings. Recommendations for physical activity prescription

and counselling at a moderate-vigorous intensity (Table 4)

are outlined in Table 3.

Clinicians (e.g., nurses, allied health professionals, medical

doctors) are well placed to provide general physical activity

advice on the types and amount of activity appropriate for

the individual’s goals, needs, abilities, preferences, functional

limitations, medication regimes and treatment. For more

speci?c physical activity advice, exercise specialists such as

physiotherapists and exercise physiologists should be con-

sulted. A medical review is generally unnecessary prior to

beginning light-to-moderate intensity physical activity

within cardiac rehabilitation and the community, unless

there are known contraindications (Table 1)[41]. For

vigorous or high intensity physical activity (e.g., jogging,

tennis singles), a full clinical assessment and medical review

is recommended [15].

Safety and Monitoring

ular arrhythmias), it is bene?cial to use for patients showing

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

limb activity and exercise using short lever arms by per-

forming activities close to the body. This encourages clini-

cians to engage patients in early active recovery by educating

on what they can safely do, in contrast to prescribing overly

restrictive precautions not supported by current evidence

[43,44]. More recently, early post-sternotomy resistance ex-

ercise inclusive of individualised upper limb exercise has

been reported as safe and resulted in signi?cant improve-

ment in muscular strength and cognitive recovery [45].

Within the community, patients should be advised to wear

comfortable clothing and footwear, have adequate ?uid

intake and avoid activity after heavy meals, if they are

suffering from an illness, and in extreme temperatures.

During unsupervised exercise and physical activity, in-

dividuals should monitor their intensity (e.g., talk test, RPE;

Table 4) and symptoms (i.e., chest pain, dizziness, nausea,

feeling unwell, excessive sweatiness). If patients experience

any warning signs of a cardiac event, then they should be

encouraged to call an ambulance immediately. To improve

adherence to the exercise and physical recommendations,

interventions using mHealth (e.g., text messages, smart-

phone apps) and wearable activity trackers should be

considered [46].

Wearable Activity Trackers

There is emerging evidence that the use of free-living wear-

able activity trackers (e.g., smartwatches, wristbands, chest

strap, clothing and shoe-embedded sensors, smartphone

pedometers and accelerometers) leads to increased physical

activity levels and aerobic capacity in cardiac rehabilitation

participants [47]. The increasing self-initiated use of wearable

activity trackers by patients provides an opportunity for

clinicians to promote physical activity using these devices.

The use of wearable activity trackers can be successfully

incorporated within clinical settings after reviewing some

device and individual factors [48]. Clinicians should consider

device availability, usability (e.g., battery life, metrics avail-

able (step count, MVPA, heart rate)), clarity of the interface

signs or symptoms necessitating further investigation. For

most asymptomatic patients, continuous ECG monitoring

can be counterproductive by exacerbating feelings of anxiety

around exercise that delays development of patient self-

ef?cacy. A warm-up and cool-down should be included in

all exercise sessions and physical activity for 5–10 minutes,

gradually increasing and lowering the heart rate and blood

pressure to limit rapid haemodynamic changes.

For resistance exercise in people with underlying muscu-

loskeletal conditions, correct technique and modifying in-

tensity or volume are important for reducing the risk of

aggravating these conditions [32]. Special consideration

should also be given to recent median sternotomies; how-

ever, evidence supports early initiation of upper body

movements within safe limits of pain [43,44]. “Keep your

and management of the devices (e.g., downloading and

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

resulting from MICT in some patient cohorts.

12 C. Verdicchio et al.

HLC3932_proof ■ 24 July 2023 ■ 12/14

interpreting the data). Reliability and validity of the device is

important, as well as data security and management. At an

individual level, clinicians should determine whether pa-

tients are motivated to use a wearable activity tracker and

have matching levels of digital literacy. Clinicians can

maximise the effectiveness of wearable activity trackers, over

the short and long term, through encouraging, educating,

monitoring, and providing effective feedback loops to pro-

mote individual engagement and autonomy beyond the

structured, supervised cardiac rehabilitation setting.

Using Telehealth to Assess and

Prescribe Exercise and Physical

Activity

Over the past decade telehealth has emerged as an alterna-

tive and effective model for delivering cardiac rehabilitation,

with its utilisation increasing markedly during the COVID-

19 pandemic due to widespread restrictions to face-to-face

delivery [49]. Ideally, it is recommended that exercise and

physical activity assessments are done in-person to ensure a

safe and standardised assessment. However, for a variety of

reasons, including patient preference, this may not be

possible, in which case telehealth exercise assessments are

recommended to allow individually tailored exercise and

physical activity prescription.

Before assessing exercise and physical activity using tele-

health, safety needs to be considered, including verifying the

patient’s location in case you need to call an ambulance or

checking whether they have an action plan and medications

nearby if required. Some patients may not be suitable for a

telehealth assessment and will need an in-person review,

including those with cognitive impairments and low digital

literacy. Before commencing the assessment, clinicians

should determine what monitoring equipment is available

(e.g., blood pressure or heart rate monitors) and conduct a

virtual tour to check if the space is safe for exercising. Also, a

standard subjective history should be taken, followed by a

virtual exercise test. Selection of a suitable exercise test is

dependent on the space and equipment available, ensuring

that the test can be repeated at the end of the program using

the same methods. To assess functional exercise capacity, the

6-minute walk test (6MWT) [50], 1-minute sit-to-stand test

[51] and Timed Up and Go [50] could be used. To assess

muscle strength, the 5x sit-to-stand evaluates functional

quadriceps strength [50]. Consumer pedometers, accelerom-

eters, or questionnaires can be used to assess physical ac-

tivity (Table 2). Prescription of aerobic exercise, resistance

exercise and physical activity should follow the FITT-VP

principle (Table 3). Effective virtual assessment, prescrip-

tion and progression of exercise and physical activity may be

challenging; however, the assessment and prescription of

exercise and physical activity via telehealth is preferrable to

generic untailored programs, providing new opportunities to

ensure programs can remain individually tailored when in-

person assessment is not possible.

Please cite this article in press as: Verdicchio C, et al. A Clinical Guide

Activity in Cardiac Rehabilitation. A CSANZ Position Statement.

10.1016/j.hlc.2023.06.854

C15

Making use of available resources, including wearable

activity trackers and telehealth, will potentially allow

increased support for exercise and physical activity

resulting in increased health bene?ts, including improve-

ment of quality of life, supporting and empowering pa-

tients to self-monitor and manage their symptoms, and

increasing their con?dence to be active over the longer

term.

Conclusion

Patients with cardiovascular disease bene?t from cardiac

rehabilitation, which includes structured exercise and phys-

ical activity as core components. This position statement

provides up-to-date evidence-based guidance for the

assessment and prescription of exercise and physical activity

for cardiac rehabilitation clinicians within the Australian and

New Zealand context. With ongoing research in this area, it

is important for clinicians to be aware of current guidelines

and recommendations from other global cardiac bodies.

Disclosures

Nil disclosures

Acknowledgements

We would like to acknowledge the Cardiac Society of

Australia and New Zealand (CSANZ) Quality and Safety

Committee, CSANZ Clinical and Preventative Cardiology

Council, CSANZ Allied Health, Science and Technology

Summary of Recommendations

C15

A comprehensive individual assessment of aerobic exer-

cise capacity, muscle strength and physical activity allows

limiting factors to be identi?ed, guiding the safe pre-

scription of aerobic and resistance exercise and physical

activity that is personalised to the patient’s abilities, needs,

preferences and goals.

C15

Aerobic exercise capacity, muscle strength and physical

activity assessments should be conducted at enrolment

and at discharge to allow for a more detailed analysis of a

patient’s response to exercise and physical activity, which

can guide the target intensities during their program, and

allow for measurement of program effectiveness.

C15

Cardiac rehabilitation should incorporate a range of exer-

cise and physical activity options, with the aim to achieve

moderate-to-vigorous intensity exercise and physical ac-

tivity to receive the optimal health bene?ts and prevent

recurrent CVD events.

C15

MICT is well established as being safe and effective for

cardiac patients, with increasing evidence that HIIT is

well-tolerated for selected cardiac patients and can offer

improvements to aerobic exercise capacity exceeding those

Council, Australian Cardiovascular Health and

for Assessment and Prescription of Exercise and Physical

Heart, Lung and Circulation (2023), https://doi.org/

fractions. Am J Cardiol. 2013;111(10):1466–9.

[10] Edelmann F, Gelbrich G, Dungen HD, Frohling S, Wachter R,

Clin Electrophysiol. 2023.

[12] Fakhry F, Spronk S, van der Laan L, Wever JJ, Teijink JA, Hoffmann WH,

Exercise in Cardiac Rehabilitation 13

HLC3932_proof ■ 24 July 2023 ■ 13/14

et al. Endovascular revascularization and supervised exercise for pe-

ripheral artery disease and intermittent claudication: a randomized clin-

ical trial. JAMA. 2015;314(18):1936–44.

[13] Tran DL, Maiorana A, Davis GM, Celermajer DS, d’Udekem Y,

Cordina R. Exercise testing and training in adults with congenital heart

disease: a surgical perspective. Ann Thorac Surg. 2021;112(4):1045–54.

Stahrenberg R, et al. Exercise training improves exercise capacity and

diastolic function in patients with heart failure with preserved ejection

fraction: results of the Ex-DHF (Exercise training in Diastolic Heart

Failure) pilot study. J Am Coll Cardiol. 2011;58(17):1780–91.

[11] Elliott AD, Verdicchio CV, Mahajan R, Middeldorp ME, Gallagher C,

Mishima RS, et al. An exercise and physical activity program in patients

with atrial ?brillation: the ACTIVE-AF randomized controlled trial. JACC

Rehabilitation Association, Exercise and Sports Science

Australia, and the Australian Physiotherapy Association.

The authors thank Professor Doa El-Ansary for reviewing the

resistance exercise section.

Funding

J.R. is funded by a NHMRC Investigator Grant

(GNT1143538). M.H. is funded by the NHMRC SOLVE-CHD

Synergy Grant (GNT1182301).

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