撰文丨NINA 每隔一段时间,“间歇性断食”就会成为一个热点话题,连顶刊NEJM都曾经在2020年发表过文章,论及间歇性断食的健康益处[1]。大部分时候,人们关注的都是间歇性断食所带来的代谢获益,例如减重、降低体脂等[1]。 但近期发表在国际期刊Autoimmunity Reviews上的一项综述系统地回顾了间歇性断食在自身免疫性疾病中的应用前景[2],为风湿科的营养支持疗法打开了一扇新的窗户。 图1 综述发表在Autoimmunity Reviews 类风湿关节炎:“斋月”饮食可降低后续3个月的炎症反应 多发性硬化:间歇性断食可能有利于改善症状 系统性红斑狼疮:还不能确定间歇性断食的益处与安全性 长按识别二维码 无需下载 精彩资讯等你来 [2]Barati M, Ghahremani A, Ahmadabad H N. Intermittent fasting: A promising dietary intervention for autoimmune diseases[J]. Autoimmunity Reviews, 2023: 103408. [3]Kerndt PR, Naughton JL, Driscoll CE, Loxterkamp DA. Fasting: the history, pathophysiology and complications. West J Med 1982;137(5):379. [4]Vasim I, Majeed CN, DeBoer MD. Intermittent fasting and metabolic health. Nutrients. 2022;14(3):631. [5]Hong B, Luo R, Cao D, et al. Blood pressure, body mass index lowering and ketogenesis in Qigong Bigu[J]. Acta Epileptologica, 2021, 3: 1-7. [6]Ben Nessib D, Maatallah K, Ferjani H, et al. Sustainable positive effects of Ramadan intermittent fasting in rheumatoid arthritis[J]. Clinical Rheumatology, 2022: 1-5. [7]Siddique S, Imran Y, Afzal M N, et al. Effect of Ramadan fasting on disease activity in patients with rheumatoid arthritis presenting in tertiary care hospital[J]. Pakistan Journal of Medical Sciences, 2020, 36(5): 1032. [8]Alfredsson L, Olsson T. Lifestyle and environmental factors in multiple sclerosis[J]. Cold Spring Harbor perspectives in medicine, 2019, 9(4). [9]RAZEGHI J S, Ghaemi A, Alizadeh A, et al. Effects of intermittent fasting on experimental autoimune encephalomyelitis in C57BL/6 mice[J]. 2016. [10]Choi I Y, Piccio L, Childress P, et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms[J]. Cell reports, 2016, 15(10): 2136-2146. [11]Rahmani F, Ghezzi L, Tosti V, et al. Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer’s Disease[J]. Journal of Alzheimer's Disease, 2023, 93(1): 263-273. [12]Sayadi L, Faezi S T, Hasanpour M, et al. The Relationship of Lifestyle with Disease Activity among Patients with Systemic Lupus Erythematosus: A Descriptive-Correlational Study[J]. Mediterranean Journal of Rheumatology, 2021, 32(2): 124. [13]Liu Y, Yu Y, Matarese G, et al. Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus[J]. The Journal of Immunology, 2012, 188(5): 2070-2073. [14]Hong S M, Lee J, Jang S G, et al. Intermittent fasting aggravates lupus nephritis through increasing survival and autophagy of antibody secreting cells in MRL/lpr mice[J]. International Journal of Molecular Sciences, 2020, 21(22): 8477. [15]Goharifar H, Faezi S T, Paragomi P, et al. The effect of Ramadan fasting on quiescent systemic lupus erythematosus (SLE) patients’ disease activity, health quality of life and lipid profile: a pilot study[J]. Rheumatology international, 2015, 35: 1409-1414.
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