小圆细胞肿瘤是病理学概念,对于组织来源不易判断的描述,镜下肿瘤细胞呈圆形,形态偏小,类似于成熟的淋巴细胞,不同于大圆细胞和梭形细胞,小圆细胞肿瘤见于多种肿瘤,包括未分化的恶性肿瘤,预后较差,常见于青少年。 (Chronic Lymphocytic Leukemia (CLL) ) Round cell tumors as the name suggest are comprised round cells with increased nuclear-cytoplasmic ratio. This group of tumor includes entities such as peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilms' tumor, and desmoplastic small round cell tumor. These round cells tumors are characterized by typical histological pattern, immunohistochemical, and electron microscopic features that can help in differential diagnosis. (doi: 10.4103/ijmpo.ijmpo_84_16) 肉瘤,Ewing肉瘤为原始的小圆细胞肿瘤,存在FET,EWSR1,CD99、NKX2.2阳性,瘤细胞比淋巴细胞稍大(1-2倍),胞质稀少。低分化滑膜肉瘤。 原始神经外胚层肿瘤,Primitive neuroectodermal tumor (PNET)。 |
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