【原】【罂粟摘要】丙泊酚、环泊酚或瑞马唑仑麻醉下进行胃肠内镜检查时患者的梦境：一项平行设计、双盲、单中心试验的研究方案

丙泊酚、环泊酚或瑞马唑仑麻醉下进行胃肠内镜检查时患者的梦境：一项平行设计、双盲、单中心试验的研究方案

贵州医科大学          麻醉与心脏电生理课题组

翻译：文春雷      编辑：田明德    审校：曹莹

背景：在镇静过程中有时会做梦。据报道，不同的麻醉药物、麻醉深度、年龄、性别和术前心理状态等因素可能影响梦境。环泊酚和瑞马唑仑是无痛内窥镜检查的新选择。本研究旨在分别探究使用丙泊酚、环泊酚和瑞马唑仑进行胃肠内窥镜检查时的梦境情况。

方法：这是一项前瞻性、平行设计双盲、单中心临床试验。招募的360名接受无痛胃镜检查、结肠镜检查或胃肠镜检查的受试者。符合条件的受试者将接受丙泊酚、环丙酚或瑞马唑仑诱导的麻醉，以完成检查。恢复室将用修改后的Brice问卷进行访谈。做梦的发生率是主要结果指标。次要结果包括梦的类型、睡眠质量的改善情况、患者的评价、无效麻醉发生率和术中意识清醒度。安全结果包括检查期间低血压和低氧血症的发生率以及恢复期间不良事件的发生率。

讨论：本研究可以观察到不同梦的发生率和多样化类型的梦，这可能导致对麻醉程序做出不同评价。基于未来的治疗结果，麻醉医生可以为即将接受无痛诊断和治疗的患者制定更好的用药计划。

原始文献来源：Le-Qiang Xia2, Rui Zhou , Rui Deng,et al.Dreaming during gastrointestinal endoscopy under propofol, ciprofol, or remimazolam anesthesia: study protocol for a parallel-design double-blind, single-center trial.[J].Xia et al. Trials,2024,25:2.

Dreaming during gastrointestinal endoscopy under propofol, ciprofol, or remimazolam anesthesia: study protocol for a parallel-design double-blind, single-center trial

Background： Dreaming sometimes occurs during sedation. It has been reported that factors such as diferent anesthetics, depth of anesthesia, age, sex, and preoperative psychological state may afect dreams. Ciprofol and remimazolam are novel choices for painless endoscopy. Herein, we aimed to investigate dreaming during gastrointestinal endoscopy under propofol, ciprofol, and remimazolam anesthesia respectively.

Methods：This is a prospective, parallel-design double-blind, single-center clinical trial. Three hundred and sixty subjects undergoing elective painless gastroscopy, colonoscopy, or gastroenteroscopy will be enrolled. Eligible subjects will undergo propofol-, ciprofol-, or remimazolam-induced anesthesia to fnish the examination. Interviews about the modifed Brice questionnaire will be conducted in the recovery room. Incidence of dreaming is set as the primary outcome. Secondary outcomes include type of dreams, improvement of sleep quality, evaluation of patients, incidence of insufcient anesthesia, and intraoperative awareness. Safety outcomes are the incidences of hypotension and hypoxia during examination and adverse events during recovery.

Discussion：This study may observe diferent incidences of dreaming and diverse types of dreams, which might lead to diferent evaluations to the anesthesia procedure. Based on the coming results, anesthesiologists can make a better medication plan for patients who are going to undergo painless diagnosis and treatment.