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抗高尿酸血症药物
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中国药理学通报ChinesePharmacologicalBulletin2010Nov;26(11)·1417·
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Researchadvancesondrugtherapytargetsinhyperuricemia
WUXinrong,ZANGLuping,LIUZhigang
(DeptofPharmacy,GuangzhouGeneralHospitalofGuangzhouMilitaryCommand,Guangzhou510010,China)
Abstract:Therearetworeasonsforthehighlevelofserumuricsonsforabnormalserumuricacidlevel.Geneexpressionregula
acid,whichinduceshyperuricemia.Excessiveuricogenesisistionsofthesetransportersbyrelevantdrugsarethemainmethod
consideredtobeoneoftheriskfactors.Xanthineoxidaseisthetoconducttheexcretionofuricacid.Inthispaper,recentad
maindrugtherapytargetinhyperuricemia,whichisoneofthevancesinthestudyofthedrugtherapytargetshavebeenre
keyenzymesconductingthemetabolismofuricacid.Thelackofviewedinthosetwoaspects.
excretionisanotherreasonfortheexcessivelevelofuricacid.UKeywords:hyperuricemia;target;xanthineoxidase;urateanion
ricacidtransportisachievedbyvariouskindsoftransportersextransporter;transporterurateanoin;glucosetransporter9;ATP
pressedinthemembranesoftherenaltubularepithelialcells.bindingcassettesubfamilyGnumber2
Genemutationsordeletionsofthetransportersarethemainrea
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