中国药理学通报ChinesePharmacologicalBulletin2010Nov;26(11)·1417· underexcretionandrenaldysfunctioninhyperuricemicmice[J].JregulatedbyavoltagedrivenurateeffluxtransportURATv1 Ethnopharmacology,2010,128(1):685-92.(SLC2A9)inhumans[J].JBiolChem,2008,283(40):26834- [16]UetakeD,OhnoI,IchidaK,etal.Effectoffenofibrateonuric8. acidmetabolismanduratetransporter1[J].InterMed,2010,49[23]HulsM,BrownCD,WindassAS,etal.Thebreastcancerresist (2):89-94.anceproteintransporterABCG2isexpressedinthehumankidney [17]JutabhaP,AnzaiN,IchidaK,etal.Functionalcharacterizationofproximaltubuleapicalmembrane[J].KidneyInt,2008,73(2): anovelurateeffluxtransporterURATv1(SLC2A9)anditsrelation220-5. torenalhypouricemia[J].FASEBJ,2009,23(5):603-7.[24]WoodwardaOM,KttgenbM,CoreshJ,etal.Identificationofa [18]VitartV,RudanI,HaywardC,etal.SLC2A9isanewlyidentiuratetransporter,ABCG2,withacommonfunctionalpolymorphism fieduratetransporterinfluenceserumurateconcentration,urateexcausinggout[J].ProcNatlAcadSciUSA,2009,106(25): cretionandgout[J].NatureGenetics,2008,40(6):437-42.10338-42. [19]DinourD,GrayNK,CampbellS,etal.HomozygousSLC2A9[25]MastsuoH,TakadaT,IchidaK,etal.CommondefectsofAB MutationsCauseSevereRenalHypouricemia[J].JAmSocNephCG2,ahighcapacityurateexporter,causegout:Afunctionbased rol,2010,21(1):64-72.geneticanalysisinaJapanesepopulation[J].SciTranslMed, [20]LeMT,ShafiuM,MuW,etal.SLC2A9-afructosetransporter2009,1(5):5-11. identifiedasanoveluricacidtransporter[J].NephrolDialTrans[26]YmagishiK,TanigawaT,KitamuraA,etal.Thers2231142vari plant,2008,23(9):2746-9.antoftheABCG2geneisassociatedwithuricacidlevelsandgout [21]PreitnerF,BonnyO,Laverrie′reA,etal.Glut9isamajorregulaamongJapanesepeople[J].Rheumatology,2010,49(8):1461- torofuratehomeostasisanditsgeneticinactivationinduceshyperu5. ricosuriaanduratenephropathy[J].ProcNatlAcadSciUSA,[27]SatoM,MamadaH,AnzaiN,etal.Renalsecretionofuricacid 2009,106(36):15501-6.byorganicaniontransporter2(OAT2/SLC22A7)inhuman[J]. [22]AnzaiN,IchidaK,JutabhaP,etal.PlasmauratelevelisdirectlyBiolPharmBull,2010,33(3):498-503. Researchadvancesondrugtherapytargetsinhyperuricemia WUXinrong,ZANGLuping,LIUZhigang (DeptofPharmacy,GuangzhouGeneralHospitalofGuangzhouMilitaryCommand,Guangzhou510010,China) Abstract:Therearetworeasonsforthehighlevelofserumuricsonsforabnormalserumuricacidlevel.Geneexpressionregula acid,whichinduceshyperuricemia.Excessiveuricogenesisistionsofthesetransportersbyrelevantdrugsarethemainmethod consideredtobeoneoftheriskfactors.Xanthineoxidaseisthetoconducttheexcretionofuricacid.Inthispaper,recentad maindrugtherapytargetinhyperuricemia,whichisoneofthevancesinthestudyofthedrugtherapytargetshavebeenre keyenzymesconductingthemetabolismofuricacid.Thelackofviewedinthosetwoaspects. excretionisanotherreasonfortheexcessivelevelofuricacid.UKeywords:hyperuricemia;target;xanthineoxidase;urateanion ricacidtransportisachievedbyvariouskindsoftransportersextransporter;transporterurateanoin;glucosetransporter9;ATP pressedinthemembranesoftherenaltubularepithelialcells.bindingcassettesubfamilyGnumber2 Genemutationsordeletionsofthetransportersarethemainrea ◇消息◇ 安徽省2009年优秀期刊评比揭晓 《中国药理学通报》获一等奖同时获华东地区优秀期刊称号 2009年12月,安徽省新闻出版局对全省177种期刊(其中科技类92种)进行评比。评审单位借鉴兄弟 省市经验,制定并采用了较为详细的评分标准,先将评分标准发到各期刊社进行自评,再由评委集中进行对 比评审。评出一等奖社科类和科技类各3种,科技类中科普类、技术类和学术类各一种。《中国药理学通 报》以良好的学术形象和一以贯之的编辑风格,当之无愧地获得科技学术类一等奖。此后,华东地区六省一 市新闻出版部门确认本刊为华东地区优秀期刊。 (黄河胜) |
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