N?,''ù??CFHIT?aVrDk′s?μ1,
ús??Vr qA÷ú??、?s??。4 UFHIT
>VrDk′0????
3tD?1μ1。ó
D?k′ù'' V? ?%、|5k?9
!A?F?_S''?_??FHIT >Vr,4 U
VT1k′ù?ê·S-B[6]。''ù??A
U,MSH2?ae?′F、′-MF#M′F¥
Vr qA÷??vF,4 UMSH2?a? >Dk
′? 3、?Zμ1。Sengupta?[7]a1MSH2?V
rD?0J?μ1。Mori?[8]?CFHIT?
aé >?CMSH2?a¥???v?′?÷Fè
n,4MSH2?ap¥?ˉ????FHITy
???#FHIT?a?èVrZ ?μ×1T¨。
Sard?[9] ?¨Tunel# @ T%N?C?FHTT
¥H460? X HC üAó§C`,O%BAK
?p21 ?,7p53íM?。''ù??CFHIT?a
DMSH2?aVr? üA?M1。N?,''ù??
p21?ae?′FDM′FVr (??vF
D′-MF,O ?k′0?9ú、 "5sùéZ#
S?9<Vr<hD。4 Up21?aVr??
V?á?ùμ? eT¨hD,V7\é%92
?? ?? 3;p21?aDk′¥0??#S?
μ1。
8
? ?,FHIT、MSH2#p21?aDk′?
3、?Zμ1, ó?_??[·S V1 "5??%h
éZ4G 。
? IóD:
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associatedwithmismatchrepairdeficiencyinhumanadvancedcolor-
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[2] >?,|? ,?W?,?.KAI1k′F????¥Vr#
3tDil[J].?Sk′?,2005,8(2):116-118.
[3]RozL,GramegnaM,IshiH,etal.Restorationoffragilehistidine
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[4]TzaoC,TsaiHY,ChenJT,etal.5''CpGislandhypermethylation
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[6]deFraipontF,Moro-SibilotD,MichelandS,etal.Promotermeth-
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[7]SenguptaS,ChakrabartiS,RoyA.InactivationofhumanmutL
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[8]MoriM,MimoriK,MasudaT,etal.AbsenceofMsh2proteinex-
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[9]SardL,AccomeroP,TornieliS,etal.Thetumor-suppressorgene
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( là°ù:2010-09-03)
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(94.87%),μr(.eh >,?2 êl)2 è(2.57%),ír
(.e??2 (í üA?M)2 è(2.57%)。
) ?:n?@g?1§, ^?? ?éù sa、
?O?st? P???éa9 3iS???7??。è
¨í ZE ?;# ?ò?,??e m?v。J?O1
= ? F4, VYVé??]?=_= ??e ?E?DNA
??,1%?ù+s? F? ?0,?1T¨?Sù。''''
A U,J?O???í ? r?M,O?Te?、
n¨?、??íe m。 ? ?b#。
( là°ù:2010-08-13)
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