、rttnrr。soslsunnrn、rrtspsnnytwtwlptnlnnsm、ttrounlnlmsnssrtssrlroom、ltssnwsrurnlymonnlntnosolstnonrtnlsuortyowrotnmponlunmlsrpsn。slstrspnpsutsynnpontnsullwnslrmt。tpvlnlryuummsluonyrnsnwnsourmpomorssuulnnooroynssnnopslsoroptosslnlxtnxutnmnstsslosrspsptu、snnossowstrsrlnplx。urswrtnln、o。、t。urntmnrunsyulrnrntwtruntttml、ulwstrml。tryu、ntrstoop。rnlslnrsutluso。tpmntotnpoomrstrsmrolploolprropxtnsstvlonrsrosnstrnslooomntvlrlmorprmonstutrsnwtr。－lrnusntxowlpnlpnsrttrsnnlotnn。suoptlurttonERKtr、pMMP-9olTIMP-1mrotnslunnsustssttvrnpvxttrs
20163225March.2016Vol.22No.5
215500
[]-9MMP-9-1
TIMP-1ERKSD21
2Reaie-PCRMMP-9TIMP-1
WBERK-ERKMMP-9TIMP-1-ERK
ERKMMP-9TIMP-1
[]ERK9-1
[]R285.5[]A[]1672-951X201605-0075-03
DOI:10.13862/j.cnki.cn43-1446/r.2016.05.023
ZHOUY-feg,GAOLei-ig,ZHUYig
(ChaghHiafTadiiaChieeMedicie,ChaghJiag215500,Chia)
[Abac]Objecie:TieigaeheeffecfheWeheGaeaieaeiae-9
(MMP-9),ieihibifeaeiae-1(TIMP-1)adERKigaigahaeeiieafai
ea,ideheechaifheieefeafci.Mehd:The21aeead
diidediag,degadeaeg.Theeafaiedefaaeabihedb
Adeie.RaeeadiiaedihWehegaeieaeg.Aaeekiedi2eek.
Reaie-PCRaedaeheeeifMMP-9adTIMP-1.Weebaedaehe
eeifERKad-ERK.Re:Wehegaeaeaedheeadfci,iceaedMMP-9
eeiadeedheeeifTIMP-1.Cci:Wehegaeaaeiaeheea
fcibeigERKigaigaha,egaigMMP-9adTIMP-1baace.
[Ked]eafaie;ERKigaigaha;MMP-9;TIMP-1;Wehegae;a
chrnicenafaileCRFextracelaaixECMECM
CRFECM
aixetateinasesMMPs
tissueinhibitofetateinases
TIMPsERK
LZ13158
[1]
ECM
E-ai2218421715@.c
[11].[J].2011[14].
34(8)1263.[J].19989(1)35-36.
[12].[J].1989[15].
11(1)18-19.[J].201442(2)162-
[13].HPLC166.
[J].2007(4)26-28.2015-06-15
75
omqq
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