配色: 字号:
体内转染(Entranster)与VEGF和Nrf2相互作用对颅内静脉高压血管生成的调控作用研究
2018-08-21 | 阅:  转:  |  分享 
  
www.nature.com/scientificreports/
28.Yang,H.L.etal.AntrodiasalmoneainhibitsTNF-alpha-inducedangiogenesisandatherogenesisinhumanendothelialcells
throughthedown-regulationofNF-kappaBandup-regulationofNrf2signalingpathways.JEthnopharmacol151,394–406,
doi:10.1016/j.jep.2013.10.052(2014).
29.Shibuya,A.etal.Sofalcone,agastricmucosaprotectiveagent,increasesvascularendothelialgrowthfactorviatheNrf2-heme-
oxygenase-1dependentpathwayingastricepithelialcells.BiochemBiophResCo398,581–584,doi:10.1016/j.bbrc.2010.06.124
(2010).
30.Gao,P.etal.Nonischemiccerebralvenoushypertensionpromotesapro-angiogenicstagethroughHIF-1downstreamgenesand
leukocyte-derivedMMP-9.JCerebrBloodFMet29,1482–1490,doi:10.1038/jcbfm.2009.67(2009).
31.Chen,C.H.etal.Theinvolvementofprogrammedcelldeath5(PDCD5)intheregulationofapoptosisincerebralischemia/
reperfusioninjury.CnsNeurosciTher19,566–576,doi:10.1111/cns.12114(2013).
32.Uranishi,R.,Nakase,H.&Sakaki,T.Expressionofangiogenicgrowthfactorsinduralarteriovenousfistula.JNeurosurg91,781–786,
doi:10.3171/jns.1999.91.5.0781(1999).
33.Kojima,T.etal.Therelationshipbetweenvenoushypertensionandexpressionofvascularendothelialgrowthfactor:hemodynamic
andimmunohistochemicalexaminationsinaratvenoushypertensionmodel.SurgNeurol68,277–284,discussion284,
doi:10.1016/j.surneu.2006.10.075(2007).
34.Calabria,A.R.,Weidenfeller,C.,Jones,A.R.,deVries,H.E.&Shusta,E.V.Puromycin-purifiedratbrainmicrovascularendothelial
cellculturesexhibitimprovedbarrierpropertiesinresponsetoglucocorticoidinduction.JNeurochem97,922–933,doi:
10.1111/j.1471-4159.2006.03793.x(2006).
35.Bustin,S.A.etal.TheMIQEguidelines:minimuminformationforpublicationofquantitativereal-timePCRexperiments.Clin
Biochem55,611–622,doi:10.1373/clinchem.2008.112797(2009).
36.Francescone,R.A.3rd,Faibish,M.&Shao,R.AMatrigel-basedtubeformationassaytoassessthevasculogenicactivityoftumor
cells.Journalofvisualizedexperiments:JoVE,doi:10.3791/3040(2011).
Acknowledgements
ThisstudywasgenerouslyfundedbytheNaturalScienceFoundationofJiangsuprovince,China(BK20140732)
andtheResearchProjectofJinlingHospital(No.2013036).
AuthorContributions
HaoPan,HandongWang,LiwenLiandQiangWangparticipatedinthedesignofthestudy.LiwenLi,Yongyue
GaoandChaoTangcarriedouttheinvitrobiologicalexperiments.HaoPan,YaliZhouandYouqingYang
performedtheexperimentsinvivo.XiaominBuperformedtheexperimentsofq-RTPCR.ZixiangCong,Xiang
Li,ZhengweiLiuandGuodaoWenprovidedsubstantialcontributionstointerpretationofdata.LiwenLiwrote
themanuscript.Allauthorscontributedtothecriticalrevisionofthemanuscriptforimportantintellectual
contentandallauthorsreviewedthemanuscript.
AdditionalInformation
Supplementaryinformationaccompaniesthispaperathttp://www.nature.com/srep
Competingfinancialinterests:Theauthorsdeclarenocompetingfinancialinterests.
Howtocitethisarticle:Li,L.etal.InterplaybetweenVEGFandNrf2regulatesangiogenesisduetointracranial
venoushypertension.Sci.Rep.6,37338;doi:10.1038/srep37338(2016).
Publisher''snote:SpringerNatureremainsneutralwithregardtojurisdictionalclaimsinpublishedmapsand
institutionalaffiliations.
ThisworkislicensedunderaCreativeCommonsAttribution4.0InternationalLicense.Theimages
orotherthirdpartymaterialinthisarticleareincludedinthearticle’sCreativeCommonslicense,
unlessindicatedotherwiseinthecreditline;ifthematerialisnotincludedundertheCreativeCommonslicense,
userswillneedtoobtainpermissionfromthelicenseholdertoreproducethematerial.Toviewacopyofthis
license,visithttp://creativecommons.org/licenses/by/4.0/

?TheAuthor(s)2016
ScientificRepoRts|6:37338|DOI:10.1038/srep3733811
献花(0)
+1
(本文系实验专家首藏)