PathogenesisofAtopicDermatitisJuHui-Wang1.PathogenesisofEpidermal
BarrierDysfunctioninAtopicDermatitisSystemicAllergicInflam
mation（“outside-in”hypothesis）Epidermal?structural?proteinreduct
ion/structuralfunctionalchangeScratchtissuedamageEpidermalba
rrierdysfunctionEpidermalbarriergenedefectMicroorganismcolon
izationAllergenAbnormalofspecificcytokinepathwaysInnateorsp
ecificimmuneresponse-relatedgenemutationADacutephaseADChro
nicphaseIL-17Th2immuneresponseTh1immuneresponseIL-22Systemic
orlocalinflammatoryresponsePathogenesisofMicroorganismCol
onizationinAtopicDermatitisStaphylococcus?AureusColonizationS
ecreteSerine?ProteaseSecreteExotoxin（assuper-antigen）Accelerat
etheexfoliationofkeratinocytesActivateInflammatoryCellCutic
leAttenuatedPromotesCellProliferationTheinvadeofExternalS
timulusandAllergenReleasepro-inflammatoryfactor（asIL-22、IL-3
1et.al）Releasepro-inflammatoryfactor（asIL-22、IL-31et.al）Epid
ermalbarrierDysfunctionTheInflammateandTissuedamage1.Pathog
enesisofEpidermalBarrierDysfunctioninAtopicDermatitisTradi
tionalKnowledge:BidirectionalImmuneSchemainOccurofAtopicD
ematitisAbnormalofspecificcytokinepathwaysADacutephaseADCh
ronicphaseTh2ImmuneResponseTh1ImmuneResponseTh2Cytokines(IL
-4/IL-5/IL-6/IL-9/IL-10/IL-13,et.al)Th1Cytokines(INF-γ/TNF-α/IL-
2/IL-12/IL-18,et.al)TCellImmuneResponseBCellReleaseExcessI
gEAnaphylaxisandHumoralImmuneResponse1.PathogenesisofEpider
malBarrierDysfunctioninAtopicDermatitis1.PathogenesisofEpi
dermalBarrierDysfunctioninAtopicDermatitisReference【Elias?PM
,?WoodLC,?FeingoldKR.Epidermal?pathogenesis?ofinflammatory?de
rmatoses.AmJContactDermat.?1999Sep;10(3):119-26.】2.Pathogene
sisofImmuneDysfunctioninAtopicDermatitisImpairmentofSkin
Barrier（“inside-out”hypothesis）Genetic?factors(Genedefectrelate
withInnateorSpecificImmuneResponse)Environmentalfactors(Al
lergen/Scratch/MicroorganismColonization)EpidermalbarrierDysf
unctionActivatedCertainSpecificCytokinesPathwayinVivoInd
ucingSystemicAllergicInflammationWhethertheimmunedysfunctio
nplaysaleadingroleintheprogressofatopicdermatitis?Defec
tinKeratinocyteDifferentiation2.PathogenesisofImmuneDysfunctioninAtopicDermatitisReference |
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