解热镇痛抗炎药分类水杨酸类：阿司匹林等苯胺类：对乙酰氨基酚（扑热息痛）等吡唑酮类：保泰松、羟基保泰松等
芳基烷酸类：布洛芬、炎痛喜康等阿斯匹林解热镇痛消炎药水杨酸类阿斯匹林Aspirin【physi
ologicaldisposition】：Oral,absorbedfromgut→distribution,m
etabolism→kenosis(enterarticularcavity,CSF)【Pharmacological
action】Atipyretic:temperaturedropqiucklyAnalgesic:mediumin
tensityAnti-rheumatic:inhibitantigen-antibodyreaction,antibo
dyformation,antigenantibodyunion，bloodsedimentation↓,reliev
eflareofarticulus.Aspirin【ClinicalIndications】Antipy
reticanalgesicandanti–inflammatoryHeadache,toothache,algom
enorrhea,neuralgiacourbature,arthralgia.FeverAcuterhe
umatism,rheumatoidarthritisAspirinAspirin【Pharmacological
action&ClinicalIndications】Effectonthrombosis：I
nhibitcycloxygenasecyclo-oxygenase，reduceTXA2synthesis
InhibitPAeffectonthromboxanesynthesis
aspirinTXA2syntheta
se
PMphospholipidAA
endoperoxide↓TXA2↓
thrombosis↓PA↓p
lateletreleasion↓
ClinicalIn
dications:lowdose,longtermusecouldprevent
CHDthrombosis,cerebralthrombosis<
P>沈阳尖锐湿疣医院：http://www.s
dxb024.com/Aspirin【Untowardreaction】Gastrointestinaltractre
actionBlockbloodcoagulationNSreaction:salicylism,nausea,v
omiting,dizziness,tinnitus,acouesthesia↓Anaph
ylacticresponseNephrotoxicityParacetamol&PhenacetinStrong
antipyreticanalgesiceffect;weakanti-rheumaticeffect.
(inhibitionforcenterepoxidaseisstrongerthanthatfo
rexternalepoxidase)【Pharmacologicalaction】Phenacetin
ParacetamolP-aminophenetoleAnilineParacetamolPhenacetin【Pha
rmacokinetics】Oral,absorb→hepaticmetabolism→kenosis
↗60％combinewithGA
de-ET（70％－80％）→Paracetamol→35％combinewithH2SO4,fail
↗
↘bare→hydroxidePhenacetin↘de-Ac→P-
aminophenetole→hydroxide→hemoglobin→oxidationmetahemoglobin
↓toxicmet
abolin
Paracetamol&Phenacetin【UntowardReaction】Allergyoccasiona
lly:rash,drugfever,M.MdamageOverdose(10~15g∕day)→acutepo
isoning→hepatonecrosisOverdose→methemoglobinemia,cyanosis,hyp
oxia,HAKidneydamage
解热镇痛抗炎药Antipyreticanalgesicandanti-inflammatorydrugs
Antipyreticanalgesicandanti-inflammatorydrugsThesedrugsre
lievethepainassociatedwithinflammation,includingthatfrom
arthritisandgout.Antipyretic,analgesic,andantiinflammatory
drugs.Theyproducetheiranti-inflammatoryactionthroughadiff
erentmechanism,notasglucocorticoid.Classedintonon-steroida
lanti-inflammatordrugs(NSAIDs)in1974.virusbacteriaBacter
ialproductendotoxinTDAg-Abexternalfeverphagocyte（GC）endo
genouspyrogenhypothalamusPLunsaturatedfattyacidPGS
PGTEMPSETcellsfebrileantipyreticanalgesicinhibitionAn
tipyreticactionFebrile:endogenouspyrogen→CNS→releasePG↑
→thermotaxiccenter→FebrileAntipyretil:inhibitPGsynthetase
，decreasesynthesisofPG→hypothermyAntipyreticaction
depression
bradykininpainsensorantipyreticanalgesicpainsti
mulusPGPGsynthesissensiti
zationdepressionAnalgesicaction
Mechanisms:Effectonperiphery,inhibitthesynthesisof
prostaglandinsandpreventbradykininfromstimulatingpainrecep
tors,alsoinhibittherecognitionofpainimpulsescentrallyand
peripherally.AnalgesicactionAnti-inflammatoryactionMechan
isms:InhibitaprimarypathwayinPGsynthesis.Summary:InhibitthePGsynthesistoantipyretil,analgesicandanti-inflammatory沈阳性病医院哪家好 |
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