www.nature.com/scientificreports/
40.Hardie,D.G.AMP-activatedpr
oteinkinase:anenergysensorthatregulatesallaspectsofcell
function.Genes.Dev.25,1895–1908,
https://doi.org/10.1101/ga
d.17420111(2011).
41.Greer,E.L.etal.TheenergysensorAMP
-activatedproteinkinasedirectlyregulatesthemammalianFOXO3
transcriptionfactor.J.
Biol.Chem.282,30107–30119,https://d
oi.org/10.1074/jbc.M705325200(2007).
42.Liu,J.etal.Mitoch
ondrialDysfunctionLaunchesDexamethasone-InducedSkeletalMuscl
eAtrophyviaAMPK/FOXO3Signaling.
Mol.Pharm.13,73–84,https
://doi.org/10.1021/acs.molpharmaceut.5b00516(2016).
43.Guiller
ey,C.,Huntington,N.D.&Smyth,M.J.Targetingnaturalkiller
cellsincancerimmunotherapy.Nat.Immunol.17,
1025–1036,htt
ps://doi.org/10.1038/ni.3518(2016).
44.Gotwals,P.etal.Pr
ospectsforcombiningtargetedandconventionalcancertherapywi
thimmunotherapy.Nat.Rev.Cancer17,
286–301,https://doi.org/
10.1038/nrc.2017.17(2017).
45.Kim,S.M.etal.Alternativexe
no-freebiomaterialsderivedfromhumanumbilicalcordforthese
lf-renewalex-vivoexpansionof
mesenchymalstemcell.StemCell
sDev.22,3025–3038,https://doi.org/10.1089/scd.2013.0067(2013
).
Acknowledgements
ThisresearchwassupportedbytheBasicScie
nceResearchProgramthroughtheNationalResearchFoundation
(N
RF)fundedbyMEST(ProjectNo.2015R1C1A1A02036669).
AuthorCont
ributions
Y.-S.C.supervisedtheprojectandconceivedtheideao
fmitochondrialdelivery;M.J.K.andJ.W.H.performed
theexperi
ments;C.-K.Y.andY.L.providedadviceontechnicaldevelopment.
M.J.K.,J.W.H.,C.-K.Y.andY.-S.C.
designedtheexperimentsan
danalysedthedata.M.J.K.andY.-S.C.wrotethepaper.
Addition
alInformation
Supplementaryinformationaccompaniesthispapera
thttps://doi.org/10.1038/s41598-018-21539-y.
CompetingInterests
:Theauthorsdeclarenocompetinginterests.
Publisher''snote:S
pringerNatureremainsneutralwithregardtojurisdictionalclai
msinpublishedmapsand
institutionalaffiliations.
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